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A kind of ginseng enzymolysate and its preparation process and application

A preparation process and enzymatic hydrolyzate technology, which is applied in the direction of drug combination, plant raw materials, medical preparations containing active ingredients, etc., to achieve the effect of improving tumor microenvironment, anti-tumor in dormant state, and good inhibitory effect

Active Publication Date: 2021-01-01
INFINITUS (CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Ginseng and its related extracts, enzymatic hydrolysates, etc. have the activity of inhibiting tumor cells themselves, but there is no related product in the current prior art that can act on MDSC and has obvious inhibitory activity

Method used

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  • A kind of ginseng enzymolysate and its preparation process and application
  • A kind of ginseng enzymolysate and its preparation process and application
  • A kind of ginseng enzymolysate and its preparation process and application

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Effect test

Embodiment 1

[0029] Embodiment 1: Preparation of Ginseng Enzymolyzate of the present invention

[0030] a. Preparation of ginseng extract: first take the decoction pieces of ginseng medicinal materials, add water 20 times the weight of the medicinal materials, extract twice for 2 hours each time, filter, and combine the filtrates to obtain the ginseng extract;

[0031] b. get the ginseng extract described in step a to obtain the concentrated solution after concentrating under reduced pressure, the liquid-to-material ratio of the concentrated solution and the ginseng medicinal material is 9ml: 1g, finally add acetic acid to the concentrated solution to adjust the pH value to 4.5, Get the ginseng concentrate and set aside;

[0032] c. Enzymolysis reaction: take the concentrated ginseng solution described in step b, keep the temperature of the concentrated ginseng solution at 45°C, add the enzymatic hydrolyzate to the concentrated ginseng solution, and then place it in an enzymatic hydrolysis...

Embodiment 2

[0036] Embodiment 2: Preparation of Ginseng Enzymolyzate of the present invention

[0037] a. Preparation of ginseng extract: first take the ginseng medicinal material, add water 15 times the weight of the medicinal material, extract twice for 2.5 hours each time, filter, and combine the filtrates to obtain the ginseng extract;

[0038] b. Get the ginseng extract described in step a and concentrate it under reduced pressure to obtain a concentrated solution. The liquid-to-material ratio of the concentrated solution and the ginseng medicinal material is 10ml: 1g. Finally, add malic acid to the concentrated solution to adjust the pH value to 5.0 , to get ginseng concentrate, set aside;

[0039] c. Enzymolysis reaction: take the concentrated ginseng solution described in step b, keep the temperature of the concentrated ginseng solution at 50°C, add the enzymatic hydrolyzate to the concentrated ginseng solution, and then place it in an enzymatic hydrolysis tank for enzymolysis re...

Embodiment 3

[0043] Embodiment 3: Preparation of Ginseng Enzymolyzate of the present invention

[0044] a. Preparation of ginseng extract: first take the ginseng medicinal material, add water 20 times the weight of the medicinal material, extract twice for 2 hours each time, filter, and combine the filtrate to obtain the ginseng extract;

[0045] b. Get the ginseng extract described in step a and concentrate it under reduced pressure to obtain a concentrated solution. The liquid-to-material ratio of the concentrated solution and the ginseng medicinal material is 12ml: 1g. Finally, add citric acid to the concentrated solution to adjust the pH value to 6.0 , to get ginseng concentrate, set aside;

[0046] c. Enzymolysis reaction: take the concentrated ginseng solution described in step b, keep the temperature of the concentrated ginseng solution at 60°C, add the enzymatic hydrolyzate to the concentrated ginseng solution, and then place it in an enzymatic hydrolysis tank for enzymolysis reac...

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Abstract

The invention relates to the technical field of traditional Chinese medicines and discloses a ginseng enzymolysis product and a preparation process and application thereof. The preparation process comprises the steps: extracting ginsengs to obtain a ginseng extracting solution, concentrating, and adjusting pH value to be in an acidity state to obtain a ginseng concentrating solution; and adding a complex enzyme into the ginseng concentrating solution for enzymolysis, and drying after enzymolysis to obtain the ginseng enzymolysis product, wherein the complex enzyme is cellulase or is one or more than two of pectinase, hemicellulose and beta-glucanase. The ginseng extracting solution is subjected to enzymolysis by using proper enzyme combination in a proper enzymolysis manner to obtain the ginseng enzymolysis product with specific saponin ingredient; the ginseng enzymolysis product has a good inhibiting effect on MDSC and colon cancer, and moreover, has a synergistic effect of inhibiting colon cancer when being combined with chemotherapy drugs.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicines, in particular to a ginseng enzymatic hydrolyzate and its preparation process and application. Background technique [0002] Malignant tumors are major diseases that seriously threaten human health. At present, the conventional treatment methods for tumors are surgical resection, radiotherapy and chemotherapy. Although some progress has been made, tumor recurrence and metastasis are common problems that plague clinical tumor treatment. The reason is that the targets of existing treatments are still focused on the tumor cells themselves, while ignoring the importance of their microenvironment. [0003] Drugs active in vitro can recognize tumor antigens and kill tumor cells. However, the recognition of tumor antigens alone is not enough to eliminate tumors formed in the body. A well-established tumor is a complex tissue composed not only of tumor cells, but also of stromal ce...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/258A61P35/00
CPCA61K36/258A61K2236/19A61K2236/331
Inventor 余庆涛葛亚中马忠华秦垂新
Owner INFINITUS (CHINA) CO LTD
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