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Botrychium ternatum micro-powder decoction pieces, Botrychium ternatum composition and preparation method of Botrychium ternatum composition

A technology of Xiaochun flower and composition, which is applied in the field of Xiaochun flower micro-powder decoction pieces and Xiaochun flower composition and its preparation, which can solve the problems of low dissolution rate and low bioavailability of active ingredients, and achieve reduction of drug dosage and biotransformation rate High and simple preparation method

Inactive Publication Date: 2017-05-10
黄萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional decoction pieces currently used in clinical practice are mainly Xiaochun flower segments and Xiaochun flower coarse powder, and the traditional decoction pieces have problems such as low dissolution rate of active ingredients and low bioavailability

Method used

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  • Botrychium ternatum micro-powder decoction pieces, Botrychium ternatum composition and preparation method of Botrychium ternatum composition
  • Botrychium ternatum micro-powder decoction pieces, Botrychium ternatum composition and preparation method of Botrychium ternatum composition
  • Botrychium ternatum micro-powder decoction pieces, Botrychium ternatum composition and preparation method of Botrychium ternatum composition

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preparation example Construction

[0035] In the present invention, the preparation method of the extract of the stems and leaves of Flos Lonicerae preferably comprises: extracting the stems and leaves of Flos Lonicerae with ethanol aqueous solution or water as an extraction solvent to obtain the stems and leaves of Flos Lonicerae extract. In the present invention, it is preferable to crush the raw material of the stems and leaves of the florida to more than 20 meshes, more preferably 50-80 meshes, and most preferably 65 meshes, before extracting the stems and leaves of the florets.

[0036] Concretely, when preparing the extract of the stem and leaf of Xiaochun flower, the present invention mixes the stem and leaf of Xiaochun flower with an extraction solvent for extraction. In the present invention, the extraction solvent is water or an aqueous ethanol solution with a volume concentration not greater than 80%; the volume concentration of the aqueous ethanol solution is preferably 30-60%, more preferably 40-50%...

Embodiment 1

[0066] Dry the root of the small spring flower at 50° C. until the water content is less than 10%. After drying, the small spring flower root is crushed to 120 mesh by airflow milling, the grinding air pressure is 0.8 Mpa, the rotating speed of the classifying wheel is 5500 rpm, and the crushing time is 6 minutes to obtain the small spring flower root powder.

[0067] The wet material is obtained by mixing the small spring flower root micropowder with dextrin and starch in a mass ratio of 1:1:1.

[0068] Put the obtained wet material into the granulator for granulation to obtain wet granules. Put the wet granules into the drying tray of the oven to dry, the thickness of the wet material in each baking tray is 1cm, the oven temperature is set at 65°C, and the drying time is 12 hours. During the drying process, turn it every 3 hours to ensure The material does not agglomerate, and is evenly dried. After the drying is stopped, the material is put into a swing-type granulator for ...

Embodiment 2

[0070] Dry the root of Xiaochun flower at 45°C until the water content is less than 5%. After drying, use a ball mill to crush the Xiaochun flower to 65 mesh, and the crushing time is 8 minutes. The crushing ball-to-material ratio is 10:1, and the ball diameter is 0.5cm. Rotating speed is 400rpm; Obtain the small spring flower root micropowder.

[0071] The small spring flower root micropowder is directly pressed into tablets to obtain the small spring flower micro powder decoction pieces.

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Abstract

The invention provides Botrychium ternatum micro-powder decoction pieces. The Botrychium ternatum micro-powder decoction pieces comprise Botrychium ternatum root micro-powder with the particle size being 65-170 meshes. The invention further provides a Botrychium ternatum composition. The Botrychium ternatum composition comprises the Botrychium ternatum root micro-powder with the particle size being 65-170 meshes and Botrychium ternatum stem and leaf extract, wherein the Botrychium ternatum stem and leaf extract is the water extract of Botrychium ternatum stems and leaves or the alcohol extract of the Botrychium ternatum stems and leaves. The Botrychium ternatum micro-powder decoction pieces and the Botrychium ternatum composition have the advantages that the dissolution rate of the effective component total flavonoids in the Botrychium ternatum micro-powder decoction pieces and the Botrychium ternatum composition is evidently increased as compared with that traditional decoction pieces, the problem that the main components especially flavonoid substances in Botrychium ternatum are hard to transfer is solved, and the bioavailability of the decoction pieces is increased; experiments show that the cough relieving, asthma relieving and fever abating effects of the Botrychium ternatum micro-powder decoction pieces and the Botrychium ternatum composition are evidently increased as compared with those of traditional Botrychium ternatum decoction pieces, and medicine taking quantity of patients is reduced.

Description

technical field [0001] The invention relates to the technical field of medicine and health care, in particular to a micronized jellyfish decoction piece and jellyfish composition and a preparation method thereof. Background technique [0002] Little spring flowers are Botrychium ternatum (Thunb.) Sw., Botrychium japonicum (Prantl) Underw., Botrychium daucifolium Wall., Botrychiaceae lanuginosum Wall., The rooted whole plant of Botrychium officinaleching, Botrychium robustum (Rupr.) Underw. or Botrychium virginianum (L.) Sw. Tianyun and so on. Xiaochunhua is a traditional medicinal material in Zhejiang Province, a characteristic medicinal material of ethnic minorities, and one of the famous seven medicines in the Qinling Mountains. It is mainly used for the treatment of kidney deficiency, wind-heat cold, bronchial asthma, whooping cough, dizziness and headache, high fever and convulsions in children, epilepsy, scrofula, fire eyes, nebula, poisonous snake bites, rabies bites...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61K9/14A61P11/14A61P11/06A61P29/00A61K125/00A61K135/00
CPCA61K36/11A61K9/14A61K2236/331A61K2236/333A61K2236/39
Inventor 黄萍戴纯辉
Owner 黄萍
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