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Preparation method of gastrointestinal motility disorder animal model

A technology for gastrointestinal motility disorders and animal models, applied in the field of animal medical models, can solve the problems of not fully conforming to diversity, reducing intestinal hormone secretion, and being unrepresentative, achieving low preparation cost, short molding time, good repeatability

Pending Publication Date: 2017-05-10
张有成
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  • Claims
  • Application Information

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Problems solved by technology

The above animal models are all specific, such as diabetes or liver cirrhosis, so they are not widely representative. At the same time, their common mechanism of gastrointestinal motility mainly affects the function of ICC cells or The secretion of intestinal hormones is reduced, which does not fully conform to the diversity of clinical DGIMD pathogenesis

Method used

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  • Preparation method of gastrointestinal motility disorder animal model
  • Preparation method of gastrointestinal motility disorder animal model
  • Preparation method of gastrointestinal motility disorder animal model

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Experimental program
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Embodiment 1

[0055] A preparation method for an animal model of gastrointestinal motility disorder, comprising the following steps:

[0056] 1. Grouping of animals

[0057] (1) Mark 78 standard SD rats from No. 1 to No. 78, half male and half male, and each rat corresponds to a fixed serial number. Then use the random number table method to divide them into 5 groups of A (n=18), B (n=18), C (n=18), D (n=18) and E (n=6), Among them, the first 4 groups were further divided into 3 groups according to different observation time, and each group had 6 rats.

[0058] 2. Interventions

[0059] (2) Group A: L-Arg intervention short-term group, intraperitoneal injection of L-Arg 5.2g / kg (20% L-Arg, 2.6ml / 100g) on ​​the first day, and the intraperitoneal injection volume was halved on the second to fifth day, namely L-Arg 2.6g / kg (20% L-Arg, 1.3ml / 100g);

[0060] (3) Group B: long-term L-Arg intervention group, intraperitoneal injection of L-Arg 5.2g / kg (20% L-Arg, 2.6ml / 100g) on ​​the first day,...

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Abstract

The invention discloses a preparation method of a gastrointestinal motility disorder animal model. SPF-grade 7-week rats are adopted, the rats with half males and half females are marked, and each rat corresponds to a fixed serial number; the rats are divided into 5 big groups equally by a random number table method, the first four groups are divided into three small big groups according to different observation time, 6 rats are in each small group, intervening measures with different duration are taken by 20 percent (w / v) L-Arg salt solution, and the experimental results are collected and analyzed; and the optimal preparation scheme of the gastrointestinal motility disorder animal model is finally obtained. The preparation method of the gastrointestinal motility disorder animal model has the advantages of simple preparation method, definite quality control index, long maintaining time, low preparation cost, appropriate disease characteristics and unique modeling mechanism.

Description

technical field [0001] The invention relates to the field of animal medical models, in particular to a method for preparing an animal model of gastrointestinal motility disorder. Background technique [0002] Gastrointestinal motility disorder is a kind of multiple neuromuscular and other abnormal diseases, which can occur in any part of the digestive tract, and is mainly characterized by gastrointestinal dysfunction, slow peristalsis, gastric emptying and small intestinal propulsion pathogenesis. It is usually divided into two categories: motility disorder and functional disorder. Common DGIMD mainly include achalasia, gastroesophageal reflux disease, functional dyspepsia, irritable bowel syndrome, slow transit constipation, gastric light paralysis, intestinal pseudo-obstruction, etc. [0003] At present, the drugs used clinically to promote gastrointestinal motility are mainly chemical drugs such as dopamine receptor antagonists, 5-HT receptor agonists and motilin recept...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01K67/02G01N33/74
CPCA01K67/02G01N33/74
Inventor 张有成王满才
Owner 张有成
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