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Agent, product and use

A technology of medicaments and uses, which is applied in the field of medicaments that regulate the dissemination of cancer cells, especially metastatic cancer cells, and can solve problems such as low efficiency and lethality

Inactive Publication Date: 2017-04-19
佩德罗巴里德拉玛泽康德德费诺萨基金会 +4
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The whole transfer process is very inefficient but hugely lethal

Method used

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Examples

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Embodiment Construction

[0172] trapping device

[0173] The decoy device of the present invention includes an agent for regulating the dissemination of metastatic tumor cells for treating and / or preventing metastatic cancer, wherein the agent for regulating the dissemination of metastatic tumor cells is carried on a reticular elastic matrix The extracellular matrix protein (ECM) on the surface, the reticular elastic matrix is ​​preferably a polycarbonate polyurethane urea matrix, prepared by coating the matrix with the ECM protein. Methods of preparing matrices are known to those skilled in the art and are described, for example, in issued US Pat.

[0174] The polycarbonate polyurethaneurea matrix (sometimes referred to as Biomerix scaffold) in the examples is nonabsorbable, reticulated, cross-linked, and the polycarbonate polyurethaneurea matrix (Biomerix, Fremont, CA, USA) provides sufficient connectivity. Porous morphology with high permeability and porosity exceeding 90-95%. The material specif...

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Abstract

The present invention relates to a composition for modulating tumor cell dissemination, in particular metastatic cancer cells. In particular, the invention relates to an agent for modulating metastatic tumor cell dissemination for use in the treatment and / or prevention of a metastatic cancer wherein the agent an extracellular matrix (ECM) protein carried on a polycarbonate polyurethane matrix. The invention also relates to a product, comprising an agent for modulating metastatic tumor cell dissemination, and to a method of treatment or prevention of cancer.

Description

technical field [0001] The present invention relates to a medicament for regulating the dissemination of cancer cells, especially metastatic cancer cells, and the use of the medicament in treating or preventing cancer. The pharmaceutical composition can capture and / or attract cancer cells, especially metastatic cancer cells. The invention also relates to a method of treating or preventing cancer. Background technique [0002] The process of cancer cell metastasis is implicated in more than 90% of cancer-related deaths and also represents a major challenge in oncology. Primary disease is somewhat amenable to surgery and / or radiation therapy, has an acceptable response to chemotherapy, and has a favorable prognosis; however, metastatic dissemination of cancer cells is a contraindication to surgery and radiation therapy related, especially resistant to chemotherapy, and have a worse prognosis. [0003] In recent years, cancer cell metastasis has been identified as a stepwise...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/06A61K38/01A61K9/19A61K47/34A61P35/04A61L31/06A61L31/14A61L31/16
CPCA61K9/0024A61K9/19A61K38/014A61K45/06A61K47/34A61L31/06A61L31/14A61L31/16A61L2300/204A61L2300/252A61L2300/416C08L75/04A61K9/0019A61K38/39A61P35/00A61P35/04B01J20/262B01J20/3021B01J20/3212B01J20/3225B01J20/3274
Inventor 亚历山大·德·拉·富恩特·冈萨雷斯拉斐尔·洛佩兹米格尔·阿巴尔·波萨达小劳伦斯·帕特里克·拉维尔
Owner 佩德罗巴里德拉玛泽康德德费诺萨基金会
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