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Application of triglyceride compound in preparation of medicine for treating polycystic ovarian syndrome

A kind of polycystic ovary and compound technology, applied in the application field of preparing medicine for treating polycystic ovary syndrome

Inactive Publication Date: 2017-04-19
ZHEJIANG XUCHEN PHARMA TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Capric triglyceride is mainly derived from natural products such as coconut oil. It is a kind of medium-chain triglyceride and has been widely used in the fields of food, medicine and cosmetics. The application of ovarian syndrome drugs has not been reported yet

Method used

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  • Application of triglyceride compound in preparation of medicine for treating polycystic ovarian syndrome
  • Application of triglyceride compound in preparation of medicine for treating polycystic ovarian syndrome
  • Application of triglyceride compound in preparation of medicine for treating polycystic ovarian syndrome

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0114] 1. Materials

[0115] 1.1 Animals

[0116] Animals 38 SPF grade female SD rats, weighing 190±10g, were provided by Hunan Slack Company.

[0117] 1.2 Drugs and reagents

[0118] Capric triglyceride was purchased from Sigma-aldrich.

[0119] 1.3 Instruments

[0120] TLL-C desktop refrigerated centrifuge was purchased from Beijing Sihuan Scientific Instrument Factory;

[0121] AU600 automatic biochemical detector, produced by Olympus;

[0122] Model 752 spectrophotometer was purchased from Shanghai Third Analytical Instrument Factory;

[0123] O1ymPus BX51 microscope, manufactured by Olympus;

[0124] BS1105 electronic balance, purchased from Germany Sartorius company.

[0125] 2. Method

[0126] 2.1 Grouping and model building

[0127] Experimental grouping: ① blank control group ② model group ③ capric triglyceride (GT) 2g / kg dose group.

[0128] Model establishment: 38 SD rats were used, among which 12 rats were the blank control group, 13 rats were the model g...

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Abstract

The invention discloses application of a triglyceride compound in the preparation of a medicine for treating polycystic ovarian syndrome. Specifically, the invention discloses application of a triglyceride compound and its pharmaceutically acceptable salt in the preparation of a composition or a preparation for treating polycystic ovarian syndrome, and / or a composition or a preparation for reducing testosterone level of mammals. The medicine of the invention can effectively treat polycystic ovarian syndrome, especially can remarkably reduce ovarian coefficient of mammals, and has little side effect.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of triglyceride compounds in the preparation of medicines for treating polycystic ovary syndrome. Background technique [0002] Polycystic ovary syndrome (PCOS) is a syndrome of endocrine disorders characterized by rare ovulation or anovulation, hyperandrogen or insulin resistance, and polycystic ovaries. Symptoms include oligomenorrhea or amenorrhea, chronic anovulation, infertility, hirsutism and acne. Due to continuous anovulation, in severe cases, the endometrium will hyperplasia and increase the risk of endometrial cancer. Therefore, early prevention of polycystic ovary syndrome can prevent menstrual disorders and infertility. [0003] At present, there are many kinds of drugs for the prevention and treatment of polycystic ovary syndrome, but there are also various problems, such as bringing various side effects to the patient's body. Therefore, it is of great sig...

Claims

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Application Information

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IPC IPC(8): A61K31/23A61P15/08A61P5/28A61K31/155
CPCA61K31/155A61K31/23A61K2300/00
Inventor 易伟徐华强段晓群吴啸川胡增仁
Owner ZHEJIANG XUCHEN PHARMA TECH CO LTD
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