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Method for extracting medical monomer used for preventing and curing hyperuricemia and gout from polygonum cuspidatum

A technology of hyperuricemia and Polygonum cuspidatum, which is applied in the field of preparation of medicinal monomers, can solve the problems of difficult scale and industrialization, low yield of monomer compounds, time-consuming and heavy taste, etc., and achieve industrialization and scale The effects of modernization, satisfying diversified needs, and convenience of taking

Inactive Publication Date: 2017-03-29
张清仲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The curative effect of traditional Chinese medicine in treating hyperuricemia and gout is remarkable, but there are some deficiencies in the use of traditional Chinese medicine in several aspects: 1. Conventional preparation and taking methods are inconvenient, such as decoction, time-consuming, heavy taste when taking, and Due to the different decoction time and decoction methods of individuals, the curative effect cannot be fully guaranteed; 2. The dosage is large, and the dosage form prepared by decoction or direct crushing contains active components and ineffective components. The dosage is large and cannot reach The effect of treating specific diseases, and may produce toxic and side effects; 3. The use of modern separation and purification technology to obtain monomer compounds has low yield and high cost, and it is difficult to achieve large-scale and industrialization; 4. Realize the monomer compound through modern synthesis technology Compound groups are still technically difficult and costly

Method used

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  • Method for extracting medical monomer used for preventing and curing hyperuricemia and gout from polygonum cuspidatum
  • Method for extracting medical monomer used for preventing and curing hyperuricemia and gout from polygonum cuspidatum

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Embodiment 1

[0020] Embodiment 1: the preparation method of capsule in the present invention

[0021] A preparation method for extracting medicinal monomers for preventing and treating hyperuricemia and gout from Polygonum cuspidatum, comprising the following steps:

[0022] Step 1, rough extraction: After pulverizing the raw material of Polygonum cuspidatum, weigh a certain quality of the raw material, add 20 times the amount of 70% ethanol and heat it under reflux for 2 hours, extract the medicinal residue, add 15 times the amount of 70% ethanol to the medicinal residue and heat it under reflux 1.5h, combine the extracts, refrigerate for 1d, centrifuge at high speed, discard the insoluble matter, and distill ethanol under reduced pressure to a relative density of 1.2 to obtain a crude extract;

[0023] Step 2, crude purification: adjust the pH value of the crude extract in step 1 to 9 with sodium hydroxide, refrigerate for 1 day, centrifuge the concentrated solution at high speed, discar...

Embodiment 2

[0025] Embodiment 2: the preparation method of tablet among the present invention

[0026] A preparation method for extracting medicinal monomers for preventing and treating hyperuricemia and gout from Polygonum cuspidatum, comprising the following steps:

[0027] Step 1, rough extraction: After pulverizing the raw material of Polygonum cuspidatum, weigh a certain quality of the raw material, add 20 times the amount of 70% ethanol and heat it under reflux for 2 hours, extract the medicinal residue, add 15 times the amount of 70% ethanol to the medicinal residue and heat it under reflux 1.5h, combine the extracts, refrigerate for 1d, centrifuge at high speed, discard the insoluble matter, and distill ethanol under reduced pressure to a relative density of 1.2 to obtain a crude extract;

[0028] Step 2, crude purification: adjust the pH value of the crude extract in step 1 to 9 with sodium hydroxide, refrigerate for 1 day, centrifuge the concentrated solution at high speed, disc...

Embodiment 3

[0030] Embodiment 3: the preparation method of mixture in the present invention

[0031] A preparation method for extracting medicinal monomers for preventing and treating hyperuricemia and gout from Polygonum cuspidatum, comprising the following steps:

[0032] Step 1, rough extraction: After pulverizing the raw material of Polygonum cuspidatum, weigh a certain quality of the raw material, add 20 times the amount of 70% ethanol and heat it under reflux for 2 hours, extract the medicinal residue, add 15 times the amount of 70% ethanol to the medicinal residue and heat it under reflux 1.5h, combine the extracts, refrigerate for 1d, centrifuge at high speed, discard the insoluble matter, and distill ethanol under reduced pressure to a relative density of 1.2 to obtain a crude extract;

[0033] Step 2, crude purification: adjust the pH value of the crude extract in step 1 to 9 with sodium hydroxide, refrigerate for 1 day, centrifuge the concentrated solution at high speed, discar...

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Abstract

The invention relates to a method for extracting a medical monomer used for preventing and curing hyperuricemia and gout from polygonum cuspidatum. The method comprises the steps that crude extraction is conducted by adding ethyl alcohol for heating reflux after a polygonum cuspidatum raw material is smashed; then the pH value of crude extract is regulated for crude purification; then polyamide resin columns are adopted for purification; eluent is identified through thin layer chromatography, and the eluent with a high ratio of the target compound is collected and combined; and finally the obtained eluent is prepared into the finished product. According to the method, the ethyl alcohol with the concentration being 70% is adopted for decoction, the polyamide resin columns are adopted for extraction, the target monomer is enriched purposefully, the cost is low, the yield is high, and industrialization and scalization are easy to achieve; and capsules, tablets and mixtures prepared through the method are convenient to take and meet diversified demands.

Description

technical field [0001] The invention relates to a preparation method of a medicinal monomer, in particular to a preparation method of a medicinal monomer for preventing and treating hyperuricemia and gout from Polygonum cuspidatum. Background technique [0002] At present, the prevention of hyperuricemia and gout is mainly to limit high-purine foods and control alcohol consumption. In terms of treatment, it is necessary to control acute-onset arthritis and long-term treatment of hyperuricemia to prevent tophi deposition. [0003] Chemotherapy is divided into treatment of gouty arthritis and correction of hyperuricemia. The former includes colchicine, non-steroidal anti-inflammatory drugs, and glucocorticoids, which can quickly and effectively relieve pain and reduce inflammation; the latter includes probenecid, benzbromarone (to promote the excretion of uric acid) and allopurine Alcohol (inhibits uric acid production). However, these drugs have many adverse reactions, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/07C07H1/08A61K31/7048A61P19/06
CPCC07H17/07A61K31/7048C07H1/08
Inventor 张清仲
Owner 张清仲
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