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Composition and application thereof in reduction of uric acid and treatment or prevention of gout

A technology of composition and medicine, which is applied in the field of composition, treatment or prevention of gout, can solve the problems of large toxic and side effects, difficulty in surgical removal, inability to treat gout, etc., and achieve the effect of reducing uric acid and treating hyperuricemia

Active Publication Date: 2017-03-08
谢灵均 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, tophi is a powder that is loosely attached to joints and other places, and it is difficult to completely remove it by surgery.
Moreover, gout is an endocrine disease. Even if tophi is removed by orthopedic surgery, it cannot treat gout.
[0004] Existing gout drugs are all chemically synthesized, with high toxicity and side effects

Method used

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  • Composition and application thereof in reduction of uric acid and treatment or prevention of gout
  • Composition and application thereof in reduction of uric acid and treatment or prevention of gout
  • Composition and application thereof in reduction of uric acid and treatment or prevention of gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0153] Compared with Comparative Examples 1 and 2 in Example 1, the uric acid-lowering effect of Example 1 in which the component ratio is 1:1 is not only better than that of Comparative Examples 1 and 2 in which any component is implemented alone, but also greater than both of them The sum of uric acid drop. Compared with the model group, Example 1-3 groups can significantly reduce uric acid. Wherein the embodiment 2 group has the most obvious effect, which is similar to the positive control drug allopurinol in curative effect. This experiment shows that composition A exerts a good synergistic effect and can significantly reduce uric acid.

[0154] A.2 Treatment of Acute Gouty Arthritis Trials

[0155] A.2.1 Experimental method

[0156] 48 male SD rats were divided into 6 groups, 8 in each group. They are blank control group, model control group, embodiment 4 group, embodiment 5 group, embodiment 6 group and indomethacin group respectively.

[0157] Table 2 (a) Examples ...

Embodiment 12

[0184] Embodiment 12: The composition of the mixture is as follows:

[0185] Marine fish oligopeptide powder (containing 10% anserine): purchased from Hubei Xinkang Pharmaceutical Chemical Co., Ltd.

[0186] Deep-sea fish oil (containing EPA 28%, DHA 12%): purchased from Wuhan Dahua Weiye Pharmaceutical and Chemical Co., Ltd.

[0187] Quercetin: sigma, produced in the United States.

[0188] Green coffee bean extract (containing 50% chlorogenic acid): Xi'an Sanjiang Biological Engineering Co., Ltd.

[0189] Grape seed extract (containing 95% proanthocyanidins): Baoji Rongde Biological Engineering Co., Ltd.

[0190] The marine fish oligopeptide powder is mixed according to the ratio in Table 4 (a), and the mixture is made into capsules as an active ingredient composition.

Embodiment 13

[0192] Marine fish oligopeptide powder (containing 10% anserine): purchased from Hubei Xinkang Pharmaceutical Chemical Co., Ltd.

[0193] Quercetin: sigma, produced in the United States.

[0194] The marine fish oligopeptide powder is mixed according to the ratio shown in Table 4 (a), and the mixture is made into a capsule as an active ingredient composition.

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PUM

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Abstract

The invention relates to a composition and application thereof in reduction of uric acid and treatment or prevention of gout. The composition provided by the invention is prepared from quercetin and anserine. The composition can effectively reduce the uric acid and treat hyperuricemia and the gout.

Description

technical field [0001] The invention relates to the field of biology, in particular to a composition and its use for reducing uric acid and treating or preventing gout. Background technique [0002] With the rapid development of my country's economy, people's living standards have improved significantly. The number of patients with hyperuricemia and gout, known as the "disease of the rich", has increased year by year. According to statistics, there are currently about 120 million people nationwide, and they are showing a trend of younger age. Gout is a disorder of purine metabolism. High uric acid is closely related to hyperlipidemia, hypertension, diabetes, etc., and has become an early sign of metabolic syndrome. Gout can develop into uremia, renal failure, arteriosclerosis, coronary heart disease, stroke, etc., which can be life-threatening in severe cases. It has been listed by the United Nations as one of the 20 major chronic diseases in the 21st century. [0003] Th...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K31/4172A61K31/352A61K31/557A61K31/216A61P19/06A23L33/10
CPCA23V2002/00A61K31/216A61K31/352A61K31/4172A61K31/557A61K38/05A61K2300/00A23V2200/30A23V2250/21168A23V2250/187A23V2250/55
Inventor 谢灵均王暖
Owner 谢灵均
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