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Application of Ternatusine A in preparation of human fungus resistant drugs

A technology against human fungi and medicines, applied in the direction of antifungal agents, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve the problems of strong accumulation of toxicity, irritation, dizziness, allergies, etc., and achieve strong inhibitory activity against human fungi The effect of sexuality

Inactive Publication Date: 2017-03-08
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pathogenic fungi seriously threaten human health and life. Antifungal drugs have been widely used as routine medications. Currently, clinically used antibacterial agents (such as ketoconazole, amikacin, gentamycin, vigorconazole, Itraconazole, terbinafine, amphotericin, fluconazole, etc.) have good curative effect on skin and superficial infection, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, digestive tract Stimulation, dizziness, allergies, etc., so looking for new antifungal drugs with a unique mechanism of action has become one of the hot spots in drug research and development today

Method used

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  • Application of Ternatusine A in preparation of human fungus resistant drugs
  • Application of Ternatusine A in preparation of human fungus resistant drugs
  • Application of Ternatusine A in preparation of human fungus resistant drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Embodiment 1: the preparation of compound Ternatusine A tablet involved in the present invention:

[0012] Take 5 grams of compound Ternatusine A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0013] Embodiment 2: the preparation of the compound Ternatusine A capsule involved in the present invention:

[0014] Get 5 grams of compound Ternatusine A, add 195 grams of starch, mix evenly, and make 1000 capsules.

[0015] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0016] Experimental example 1: Ternatusine A anti-human fungal activity

[0017] The anti-fungal activity experiment against human body adopts the method of concentration dilution, and each determination is repeated three times. The test pathogens include Trichomonas rubrum, Microsporum lanoides and Trichomonas clumps, and the concentration of bacteria solution is 105 / mL. The initial concentration of Ternatusine A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and the equal volume of bacterial liquid and test samples are mixed and cultured in a 96-well plate at the human fungal culture temperature 28°C respectively, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of Ternatusine A against human fungi are shown in Table 1.

[0018] Table 1 Ternatusine A anti-human funga...

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Abstract

The invention relates to application of Ternatusine A in the preparation of human fungus resistant drugs and belongs to the field of medicine. Ternatusine A has great action for inhibiting Trichophyton rubrum, Microsporum lanosum or Trichophyton tonsurans, and therefore, Ternatusine A may act as human fungus resistant compounds and is expectedly applicable to the preparation of related drugs.

Description

technical field [0001] The present invention relates to a new application of compound Ternatusine A, in particular to the application of Ternatusine A in the preparation of antifungal drugs for human body. Background technique [0002] Pathogenic fungi seriously threaten human health and life. Antifungal drugs have been widely used as routine medications. Currently, clinically used antibacterial agents (such as ketoconazole, amikacin, gentamycin, vigorconazole, Itraconazole, terbinafine, amphotericin, fluconazole, etc.) have good curative effect on skin and superficial infection, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, digestive tract Stimulation, dizziness, allergies, etc., so looking for new antifungal drugs with unique mechanism of action has become one of the hot spots in drug research and development today. [0003] The compound Ternatusine A involved in the present invention is a compound published in 2013 ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/407A61P31/10
CPCA61K31/407Y02A50/30
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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