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Trandolapril-containing pharmaceutical composition and preparation method thereof

A technology for trandolapril and its composition, which is applied in the field of pharmaceutical compositions containing trandolapril, can solve problems affecting drug efficacy, achieve the effects of reducing roughness, facilitating storage, and shortening the time for dissolution or disintegration

Inactive Publication Date: 2017-02-15
ABA CHEM SHANGHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the oral solid pharmaceutical composition containing trandolapril of the present invention still has certain defects: but in the preparation process of the pharmaceutical composition of the present invention, there is friction between the tablet and the die hole wall, which in turn will affect the final drug effect

Method used

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  • Trandolapril-containing pharmaceutical composition and preparation method thereof
  • Trandolapril-containing pharmaceutical composition and preparation method thereof
  • Trandolapril-containing pharmaceutical composition and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The present embodiment contains the pharmaceutical composition of trandolapril, and this pharmaceutical composition is made up of the raw material of following parts by weight: 2 parts of trandolapril, 1500 parts of filler pregelatinized starch (2.5 parts of cornstarch, 5 parts of potato starch and 2.5 parts of rice starch), 45 parts of binder ethanol, 36 parts of disintegrating agent, 10 parts of glidant talc powder and 6 parts of lubricant; among them, the disintegrating agent is croscarmellose sodium and croscarmellose A mixture of crospovidone, 19.64 parts of croscarmellose sodium and 16.36 parts of crospovidone; the lubricant is a mixture of magnesium lauryl sulfate and magnesium stearate, 2.22 parts of magnesium lauryl sulfate and stearin Magnesium acid 3.78 parts.

[0028] The present embodiment contains the preparation method of the pharmaceutical composition of trandolapril, and the specific steps of this preparation method are as follows:

[0029] (1) Weigh t...

Embodiment 2

[0035] The present embodiment contains the pharmaceutical composition of trandolapril, and this pharmaceutical composition is made up of the raw material of following parts by weight: 2 parts of trandolapril, 1500 parts of filler pregelatinized starch (2.5 parts of cornstarch, 5 parts of potato starch and 2.5 parts of rice starch), 45 parts of binder ethanol, 36 parts of disintegrating agent, 10 parts of glidant talc powder and 6 parts of lubricant; among them, the disintegrating agent is croscarmellose sodium and croscarmellose A mixture of povidone, 21 parts of croscarmellose sodium and 15 parts of crospovidone; the lubricant is a mixture of magnesium lauryl sulfate and magnesium stearate, 1.94 parts of magnesium lauryl sulfate and stearin Magnesium acid 4.06 parts.

[0036] The present embodiment contains the preparation method of the pharmaceutical composition of trandolapril, and the specific steps of this preparation method are as follows:

[0037] (1) Weigh trandolapri...

Embodiment 3

[0043]The present embodiment contains the pharmaceutical composition of trandolapril, and this pharmaceutical composition is made up of the raw material of following parts by weight: 2 parts of trandolapril, 1500 parts of filler pregelatinized starch (2.5 parts of cornstarch, 5 parts of potato starch and 2.5 parts of rice starch), 45 parts of binder ethanol, 36 parts of disintegrating agent, 10 parts of glidant talc powder and 6 parts of lubricant; among them, the disintegrating agent is croscarmellose sodium and croscarmellose A mixture of crospovidone, 20.35 parts of croscarmellose sodium and 15.65 parts of crospovidone; the lubricant is a mixture of magnesium lauryl sulfate and magnesium stearate, 2.07 parts of magnesium lauryl sulfate and stearin Magnesium acid 3.93 parts.

[0044] The present embodiment contains the preparation method of the pharmaceutical composition of trandolapril, and the specific steps of this preparation method are as follows:

[0045] (1) Weigh tr...

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Abstract

The invention relates to a trandolapril-containing pharmaceutical composition. The composition is prepared from, by weight, 1-2 parts of trandolapril, 10-60 parts of a filling agent, 5-45 parts of adhesives, 4-36 parts of a disintegrating agent, 2-10 parts of a flow aid and 4-6 parts of a lubricating agent, wherein the lubricating agent is a mixture of cinnamyl magnesium sulfate and magnesium stearate in a weight ratio of 1:1.7-2.1. The trandolapril-containing pharmaceutical composition has advantages that by synergistic effects and strict control of ratios of components, efficacies of the pharmaceutical composition is greatly improved; in addition, stability and controllability in quality and safety and effectiveness in clinical application are realized, and the pharmaceutical composition can be completely disintegrated in water within 2min and is convenient to store, transport and carry.

Description

technical field [0001] The invention belongs to the field of medicines, in particular to a pharmaceutical composition containing trandolapril [0002] and its preparation method. Background technique [0003] Hypertension is defined as elevated arterial systolic and / or diastolic blood pressure at rest. Hypertension is a systemic disease characterized by elevated arterial pressure, which may be accompanied by functional or organic changes in the heart, blood vessels, brain, kidneys and other organs. It has primary hypertension and secondary hypertension points. There are many reasons for the onset of hypertension, which can be divided into two aspects: genetic and environmental. [0004] In addition, elevated blood pressure is also the fuse of many diseases, which will increase the risk of coronary heart disease, heart failure and kidney diseases. Since some hypertensive patients have no obvious clinical symptoms, hypertension is also known as the "invisible killer" of hu...

Claims

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Application Information

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IPC IPC(8): A61K38/05A61K9/48A61K47/36A61K47/38A61K47/32A61K47/02A61P9/12
CPCA61K38/05A61K9/485A61K9/4866
Inventor 张敏华毛建勇张敏康
Owner ABA CHEM SHANGHAI
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