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Rubia active ingredient and its composition and application

A technology of active ingredients and compositions, applied in the field of traditional Chinese medicine, can solve the problems of unidentified active ingredients, etc., and achieve the effect of clear ingredients, definite curative effect, and controllable quality

Active Publication Date: 2019-07-12
JIANGSU KANION PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] It has been reported in the literature that the alcohol extract of Rubia has strong antipyretic and analgesic effects and anti-inflammatory activity (Liu Jiancheng, Xu Lanzhi, Chen Weining, Gao Er, Zhang Wei. Antipyretic and analgesic effects of Rubia alcohol extract[J ].Journal of Weifang Medical College, 2002,24(1):4-5.), there are also reports in the literature that the total anthraquinone of Rubia has anti-inflammatory and anti-rheumatic effects and anti-inflammatory and immune effects (Feng Xiuxiang, Xu Lanzhi, Gao Er, Chen Weining .The antipyretic and analgesic effects of total anthraquinones of rubia chinensis[J].Journal of Weifang Medical College, 2002,24(1):6-7.), but the active ingredients that play the role have not been determined

Method used

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  • Rubia active ingredient and its composition and application
  • Rubia active ingredient and its composition and application
  • Rubia active ingredient and its composition and application

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preparation example Construction

[0040] The present invention also provides a preparation method of the above-mentioned rubia active ingredient composition, comprising the following steps:

[0041] Step a: Extract Rubia with ethanol to obtain dilute extract.

[0042] Step b: extract the dilute extract obtained in step a with the first organic solvent, combine the extracts, recover the organic solvent under reduced pressure, and dry to obtain the extract;

[0043] Step c: The extract obtained in step b is separated by column chromatography, eluted with a mixed solvent of dichloromethane and methanol, the eluate is collected, concentrated under reduced pressure, detected by HPLC, and the fractions are combined to obtain hydroxyrubidolin and Rubidolin;

[0044] Step d: Mixing the hydroxyrubizin and rubidin prepared in step c according to a certain weight ratio to obtain the madder active ingredient composition. The invention also provides the application of the rubia active ingredient composition in the prepar...

Embodiment 1

[0061] The preparation of embodiment 1 extract extract

[0062] Take 5 kg of dried root or rhizome of Rubiaceae plant Rubiae, add 5 times the amount of 85% ethanol and heat and reflux for extraction 3 times, each time for 2 hours. Combine ethanol and reflux the extracts, filter and concentrate the filtrate to recover ethanol to obtain 625.3 g of extract.

Embodiment 2

[0063] The preparation of embodiment 2 extract extract

[0064] Take 5 kg of dry roots or rhizomes of Rubiaceae plant Rubiae, add 7 times the amount of 70% ethanol and heat and reflux to extract twice, each time for 2 hours. Combine ethanol and reflux the extracts, filter and concentrate the filtrate to recover ethanol to obtain 611.4 g of extract.

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Abstract

The invention relates to the technical field of traditional Chinese medicines, and in particular relates to active ingredients of rubia cordifolia, a composition of the active ingredients, and applications of the composition. The invention provides the active ingredients of rubia cordifolia having the efficacies of purging heat and resisting inflammation. The composition of the active ingredients of rubia cordifolia is obtained through ethanol extraction, ethyl acetate extraction, and separation of the silicagel column. The invention further provides the applications of the medicinal composition with the efficacies of purging heat and resisting inflammation in preparing medicines for treating fever and inflammation. For the active ingredients of rubia cordifolia, and the composition provided by the invention, the components of the composition of the active ingredients of rubia cordifolia (with the efficacies of purging heat and resisting inflammation) have good synergetic functions of purging heat and resisting inflammation, therefore, the efficacies better that of the single component can be generated, and thus the active ingredients and the composition have good clinical medication development prospect.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to the active ingredient of rubia chinensis and its composition and application. Background technique [0002] At present, clinical antipyretic drugs mainly include non-steroidal anti-inflammatory drugs and steroid antipyretic drugs. The former includes salicylic acid, aniline, Ppiridone, and other anti-inflammatory organic acids. The common mechanism of action of these drugs is to reduce the synthesis of prostaglandin (PG) by inhibiting cyclooxygenase, so as to regulate body temperature. The central SP returns to normal and produces antipyretic effect, but these drugs simultaneously inhibit the synthesis of gastric mucosal PG, increase gastric acid secretion, weaken the barrier function, cause adverse reactions in the gastrointestinal tract, and even cause severe gastric mucosal damage. Duodenal bleeding and ulcers. Due to its many components, traditional Chi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/352A61K31/122A61P13/08A61P29/00
CPCA61K31/122A61K31/352
Inventor 萧伟房卉刘文君李海波孟兆青黄文哲王振中胡晗绯
Owner JIANGSU KANION PHARMA CO LTD
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