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Method for establishing miniature pig rib fracture fixation animal model and method for evaluating absorbable rib fracture fixator

A technology for rib fracture and immobilization of animals, which is applied in the field of biomedicine and can solve problems such as the lack of uniform regulations on the evaluation of the use of fracture fixators

Inactive Publication Date: 2017-02-01
孙立旦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] There are many fracture fixators on the market at present, but there is no uniform regulation on the evaluation of the use of these fracture fixators

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Constructing a Miniature Pig Rib Fracture Fixation Animal Model

[0036] (1) Experimental miniature pigs (Beijing DB-11); body weight: 30±5kg; sex: male or female.

[0037] (2) Instruments and materials: conventional surgical instruments, orthopedic surgical instruments, respiratory anesthesia machines, water baths, narcotic drugs, first aid drugs, disinfection drugs, operating room consumables, etc.

[0038] (3) Animals were weighed before operation, blood was collected, blood phase was determined, and serum was separated for biochemical testing.

[0039](4) Anesthesia: Lumianning II (Jilin Huamu Animal Health Products Co., Ltd.; 2014.04, December 2014) was used for intramuscular injection at a dose of 0.1 mL / kg, and then a tracheal tube with an inner diameter of 7.5 mm was used to inhale the anesthetic. Isoflurane, the dosage of isoflurane depends on the depth of anesthesia in minipigs.

[0040] (5) skin preparation

[0041] After the anesthesia, place the miniatur...

Embodiment 2

[0045] Evaluation of the absorbable rib fracture fixator using the minipig rib fracture fixation animal model constructed in Example 1

[0046] Evaluation method:

[0047] (1) Put the absorbable rib fracture fixator in a water bath at 100 degrees Celsius for 3 minutes, and after it softens, quickly put it into a water bath at 60 degrees Celsius, and then take it out quickly.

[0048] (2) The softened absorbable rib fracture fixator was quickly embraced at the rib fracture joint of the animal model of rib fracture fixation in miniature pigs, and the broken ends were well aligned and fixed securely during fixation.

[0049] (3) Suture the muscle and pleura intermittently together, close the chest cavity, suture the skin, and disinfect the wound.

[0050] (4) After the operation, intramuscular injection of 1.6 million IU penicillin sodium injection was performed daily to prevent infection.

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Abstract

The invention discloses a method for establishing a miniature pig rib fracture fixation animal model and a method for evaluating an absorbable rib fracture fixator by utilizing the animal model. The method for establishing the miniature pig rib fracture fixation animal model comprises the following steps: weighing and performing anesthetic treatment on a miniature pig; lying the miniature pig which is subjected to the anesthetic treatment on the left side to expose a right side, and performing skin preparation treatment at a thorax position; notching for 9 to 11 cm along the parallel position of the sixth rib, cutting intercostal muscles, and bluntly separating a pleura from the rib; biting off an intermediate position of the sixth rib by using a bone ribbing rongeur to obtain the miniature pig rib fracture fixation animal model. By adopting the method for establishing the miniature pig rib fracture fixation animal model, the absorbable rib fracture fixator can be tested and evaluated by the obtained animal model, so that the fracture fixing performance of the absorbable rib fracture fixator is evaluated, and guidance is provided for the research and development of the absorbable rib fracture fixator.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a method for constructing a miniature pig rib fracture fixation animal model and a method for evaluating an absorbable rib fracture fixator using the animal model. Background technique [0002] There are many fracture fixators on the market at present, but there is no uniform regulation for the evaluation of the use of these fracture fixators. Contents of the invention [0003] The present invention aims to solve one of the technical problems in the related art at least to a certain extent. For this reason, an object of the present invention is to propose the method for constructing miniature pig rib fracture fixation animal model and utilize this animal model to evaluate the method for absorbable rib fracture fixator, utilize this miniature pig rib fracture fixation animal model to be able to absorb effectively The rib fracture fixator should be evaluated to provide a reliable basi...

Claims

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Application Information

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IPC IPC(8): A61D1/00A61B17/68
CPCA61D1/00A61B17/68
Inventor 孙立旦杨飞霞李英俊
Owner 孙立旦
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