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Medicine-applying filming support

A covered stent and drug application technology, applied in the field of medical devices, can solve the problems of hindering the endothelialization process in the stent cavity, proliferating and restenosis of the stent intima, and increasing the probability of thrombosis, so as to promote the endotheliumization of the lumen and reduce the foreign body. area, reducing the effect of port irritation

Active Publication Date: 2017-01-25
ZHEJIANG BELONGS TO A MEDICAL INSTR
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Currently, drug-coated stent-grafts for small-diameter arteries such as iliac arteries and femoral arteries still have some defects: 1. The outer wall of fully drug-coated stent-grafts is relatively smooth, which makes it easier to shift than bare metal stents. The existing technology adds barbs at both ends of the stent, but this will damage the normal vascular endothelium; 2. The shrinkage, collapse and damage of the covering film cause the weak or damaged area of ​​the covering film to form stent intimal proliferation restenosis or internal fistula ; 3. When used in peripheral small-caliber blood vessels, the probability of early thrombosis increases, and the coated material hinders the endothelialization process in the stent cavity, resulting in late thrombosis; 4. The drug-coated covered stent for peripheral arterial occlusive diseases End stenosis is still unavoidable

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] A drug-coated stent, comprising a stent body 1, an inner film 2, and an outer film 3, the inner film 2 is closely attached to the inner cavity of the stent body 1, the inner film 2 and the stent body 1 is fixedly connected; the outer membrane 3 is combined with the inner membrane 2 through heat sealing, microsurgical suture, etc.; the stent body 1 is provided with an inner membrane 2 to form a membrane area, and the outer membrane 3 is wound around the The outer surface of the stent body 1 is opposite to the covered membrane area, and the adventitia 3 wraps the stent body 1 firmly in the middle of the inner and outer membranes. A bare stent area is formed on the stent body 1 where the inner covering film 2 is not provided, and the bare stent area and the covered film area are arranged alternately in sequence.

[0045] The stent body 1 is braided by a monofilament, the diameter of the selected monofilament is 0.1-0.5mm, and the material is a nickel-titanium shape memory ...

Embodiment 2

[0051] On the basis of Embodiment 1, the metal stent body is made by laser cutting. By laser engraving the pipe, the remaining materials and residues are removed, and then after pickling, electrochemical polishing, cleaning, drying and other processes, a metal bracket body that meets the requirements is formed. Preferably, the pipe is a nickel-titanium alloy pipe meeting the requirements of the medical implant standard (ASTM F2063). Preferably, the diameter of the pipe is 1.65-5.0 mm. The structural characteristics and process of the drug-coated stent graft in this example are the same as those in Example 1. After testing, the radial support force of the laser-cut stent body before coating is 0.62-1.86N / mm, and the overall radial support force of the drug-coated stent after coating is 0.71-1.95N / mm, which improves the stent The support strength of the vascular lumen.

Embodiment 3

[0053] Due to the lumen isolation principle of drug-coated stent-grafts, the endothelialization process of the stent is largely restricted, resulting in a high risk of late restenosis. In view of the above shortcomings, on the premise of not affecting the lumen isolation principle of the drug-coated stent graft, by adding a through hole 5 with a certain aperture on the inner covering film 2, such as Figure 6 As shown, the entrance for the growth of endothelial cells is fully provided, and the process of endothelialization of the lumen is further accelerated. The method of adding the through hole 5 may be laser drilling. In another way, it is also possible to retain the bare stent area at both ends, cancel the bare stent area in the middle section of the drug-coated stent, and increase a large number of through holes with a certain pore size, such as Figure 7 As shown, good results can also be achieved. The above-mentioned method of adding through holes 5 may be laser drill...

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Abstract

The invention discloses a medicine-applying filming support. The medicine-applying filming support comprises a supporting body, an inner film and an outer film. The inner film is closely attached to an inner cavity of the support body and fixedly connected with the support body; filming areas are formed in the portions, provided with the inner film, of the support body, the outer film is wound around the support body relative to the outer surface of the filming areas, and the support body is firmly wrapped by the outer film in the middle of the inner film and the outer film; bare support areas are formed in the portions, not provided with the inner film, of the support body, and the bare support areas and the filming areas are sequentially and alternately arranged. According to the medicine-applying filming support, the bending performance of the filming support is improved through the filming mode; meanwhile, the wall attaching performance and the stability of the filming support are improved, and the problem that the filming support is prone to shifting is effectively solved. The inner cavity of the film is coated with anticoagulation medicine, and thrombosis is reduced; the whole outer wall of the filming support is loaded with medicine for inhibiting smooth-muscle-cell proliferation and migration, and restenosis of the inside and the two ends of the postoperation support cavity is effectively prevented.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a drug-coated stent graft. Background technique [0002] Since parieli took the lead in successfully treating abdominal aortic aneurysms with drug-coated stent-grafts in 1991, drug-coated stent-grafts have been widely used in aortic lesions. With the development of peripheral vascular intervention technology, small-caliber peripheral drug-coated There are more clinical reports of covered stents in clinical use. [0003] Drug-coated stent-grafts are composed of ordinary bare metal stents covered with special polymer membrane materials, and are an effective combination of the supporting physical and chemical properties of bare metal stents and the unique properties of the covering materials. In the treatment of peripheral arterial occlusive or stenotic diseases, the physical barrier effect of the coating material is used to limit the proliferation of the intima in the stent lumen, e...

Claims

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Application Information

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IPC IPC(8): A61F2/07A61M31/00
CPCA61F2/07A61M31/00A61M2210/12
Inventor 赵中覃元平李峥高飞李秋华
Owner ZHEJIANG BELONGS TO A MEDICAL INSTR
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