Sodium tetradecyl sulfate crystal form and preparation method, application and pharmaceutical composition containing sodium tetradecyl sulfate crystal form
A technology of sodium tetradecyl sulfate and composition, applied in the field of medicinal chemistry, achieves the effects of good reproducibility, easy industrialization, and high HPLC purity
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Embodiment 1
[0039] Preparation of Sodium Tetradecyl Sulfate Crystal Form:
[0040] Add 20g of sodium tetradecyl sulfate into 180g of purified water, stir and dissolve at room temperature, filter under reduced pressure with a 0.45μm microporous membrane, pour the filtrate into a stainless steel freeze-drying tray, the height of the solution in the freeze-drying tray should not exceed 12cm, and then put Freeze-dry in a freeze-drying oven at -30°C for 38 hours to obtain the crystal form of sodium tetradecyl sulfate.
[0041] The X-ray powder diffraction pattern, infrared spectrogram and differential scanning pattern of this crystal form are as follows: figure 1 , figure 2 and image 3 shown.
Embodiment 2
[0043] Preparation of Sodium Tetradecyl Sulfate Crystal Form:
[0044] Add 20g of sodium tetradecyl sulfate into 180g of purified water, stir at room temperature to dissolve, then add 10g of ethanol and stir evenly, filter under reduced pressure with a 0.45μ microporous filter membrane, pour the filtrate into a stainless steel freeze-drying tray, the solution height in the freeze-drying tray is It should not exceed 12 cm, and then freeze-dried in a freeze-drying oven at -5°C for 37 hours to obtain the crystal form of sodium tetradecyl sulfate.
[0045] The X-ray powder diffraction pattern, infrared spectrogram and differential scanning pattern of this crystal form are as follows: figure 1 , figure 2 and image 3 shown.
Embodiment 3
[0047] Preparation of Sodium Tetradecyl Sulfate Crystal Form:
[0048] Add 20g of sodium tetradecyl sulfate into 180g of purified water, stir at room temperature to dissolve, then add 20g of ethanol and stir evenly, filter under reduced pressure with a 0.45μ microporous filter membrane, pour the filtrate into a stainless steel freeze-drying tray, the solution height in the freeze-drying tray is It should not exceed 12 cm, and then freeze-dried in a freeze-drying oven at -10°C for 36 hours to obtain the crystal form of sodium tetradecyl sulfate.
[0049] The X-ray powder diffraction pattern, infrared spectrogram and differential scanning pattern of this crystal form are as follows: figure 1 , figure 2 and image 3 shown.
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