Therapeutic apparatus for treating maternal-fetal blood group incompatibility-type hemolytic disease

A technology of blood type incompatibility and therapeutic equipment, applied in blood filtration, blood circulation treatment, suction equipment, etc.

Active Publication Date: 2017-01-04
ATTACHED OBSTETRICS & GYNECOLOGY OSPITAL MEDICALCOLLEGE ZHEJIANG UNIV +1
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  • Abstract
  • Description
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Problems solved by technology

But so far there is no report on the design of the treatment of blood group incompatibility hemolytic disease according to the above mechanism

Method used

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  • Therapeutic apparatus for treating maternal-fetal blood group incompatibility-type hemolytic disease
  • Therapeutic apparatus for treating maternal-fetal blood group incompatibility-type hemolytic disease
  • Therapeutic apparatus for treating maternal-fetal blood group incompatibility-type hemolytic disease

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Embodiment Construction

[0012] figure 1 It is an application schematic diagram of the therapeutic instrument for maternal-fetal blood group incompatibility hemolytic disease proposed according to the present invention.

[0013] figure 2 It is the internal structure diagram of the plasma separator proposed according to the present invention.

[0014] image 3 is the internal structure diagram of the adsorber proposed according to the present invention.

[0015] figure 1 Among them, one end of the arterial blood line tube (1) is connected with the arterial blood vessel, and the other end is connected with the plasma separator (4) through the heparin pump (2) and the blood pump (3), and the plasma separator (4) is connected through the plasma pump (6) ) and circulation pipeline (7) are connected with two parallel adsorbers (8) and adsorber (9), and then connected with circulation pipeline (10) and venous pipeline (5) in turn, and venous pipeline (5) The other end is connected to the vein.

[0016] ...

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Abstract

The invention relates to a therapeutic apparatus for treating a maternal-fetal blood group incompatibility-type hemolytic disease in the medical field. The therapeutic apparatus is characterized in that hemoglobin with toxic and side effects is removed from Rh-positive red blood cells through diapedesis by using PB lysate, but ghost cells which only absorb an Rh antibody and do not absorb other blood group antibodies are retained; together with an immunologically prepared anti-Rh antibody, the ghost cells are fixed to agarose with a special concentration according to a specific ratio; thereafter, the agarose is enwrapped by a cylindrical container made of a highly-biocompatible material so as to form gradually decreasing antibody valence, gradually increasing agarose concentration and uniform ghost cell distribution from a sample inlet end to a sample outlet end; near the sample outlet end, the agarose with the special concentration with gradually increasing concentration and gradually diminishing micropores can effectively intercept fragments formed after the red blood cells of a patient suffering from the hemolytic disease are destroyed, as well as macromolecular immune complexes combined with the fragments. The therapeutic apparatus provides a new toxic and side effect-free method for treating the maternal-fetal blood group incompatibility-type hemolytic disease, by which only pathogenic antibodies are removed, but plasma components are not removed.

Description

technical field [0001] The invention relates to a therapeutic apparatus for maternal-fetal blood group incompatibility hemolytic disease used in the medical field, which is mainly used for removing anti-fetal red blood cell antibodies and red blood cell lysates in plasma of pregnant women with maternal-fetal blood group incompatibility. Background technique [0002] The fetus inherits half of the genetic components of the father and half of the mother, and the fetal red blood cells can carry antigens from the father, showing that the blood type of the fetus is different from that of the mother. When the fetal red blood cells enter the mother's blood circulation, the mother's immune system is induced to produce antibodies, and the antibodies pass through the placenta and enter the fetal blood circulation system, combining with fetal red blood cells, causing fetal red blood cells to be destroyed, resulting in maternal-fetal blood group incompatibility hemolytic disease in fetus...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/34A61M1/36
CPCA61M1/3496A61M1/3601A61M1/3621A61M1/3693
Inventor 翁炳焕李兰娟
Owner ATTACHED OBSTETRICS & GYNECOLOGY OSPITAL MEDICALCOLLEGE ZHEJIANG UNIV
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