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Calcipotriol composition with improved stability

A technology of calcipotriol and composition, applied in the field of compositions containing calcipotriol, capable of solving problems such as incomplete solution

Inactive Publication Date: 2017-01-04
JIANGSU SEMPOLL PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] The above-mentioned technology does not completely solve the above-mentioned problems, and the stability of the composition containing calcipotriol still has a large room for improvement

Method used

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  • Calcipotriol composition with improved stability
  • Calcipotriol composition with improved stability
  • Calcipotriol composition with improved stability

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The composition is as follows:

[0034]

[0035] Description: The neutralization degree of caprylic capric glyceryl arginine ester is 80%.

Embodiment 2

[0037] The composition is as follows:

[0038]

[0039] Description: The neutralization degree of caprylic capric glyceryl arginine ester is 0%.

Embodiment 3

[0041] The composition is as follows:

[0042]

[0043] Description: The neutralization degree of caprylic capric glyceryl arginine ester is 0%.

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PUM

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Abstract

The invention discloses a calcipotriol composition with the improved stability. The composition is prepared from a vitamin D derivative or an analog (like calcipotriol), caprylic / capric glycerides arginine esterase and a pharmaceutically receivable additive. The stability of the composition is improved.

Description

technical field [0001] The present invention relates to a composition containing calcipotriol. More specifically, a calcipotriol-containing composition with improved stability. Background technique [0002] Calcipotriol ointment is mainly used for the treatment of stable plaque psoriasis suitable for topical treatment, and has become the drug of choice for the treatment of this disease. [0003] However, such topical pharmaceutical compositions containing vitamin D analogs suffer from stability problems. For example, calcipotriol is less stable at pH values ​​below 8. Improvements have been made to a certain extent in the prior art for the above problems, for example: [0004] Patent CN00807667.7 discloses that the composition containing calcipotriol uses a solvent whose general formula is R(OCHC(R)H)xOR(I) as a stability protector, preferably polyoxypropylene-15-S-stearyl ether , Dovobet calcipotriol ointment, a product listed by Leo Pharmaceuticals, uses polyoxypropy...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K31/593A61K31/59A61K47/18A61P17/06A61P17/10A61P17/00
CPCA61K31/593A61K9/0014A61K9/06A61K31/59A61K47/18
Inventor 蔡蓓蕾王学政陈玉兰
Owner JIANGSU SEMPOLL PHARMA
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