A Hyperpolarized Xenon Magnetic Resonance Method Based on Spectrum-Image Integration

A hyperpolarization and magnetic resonance technology, applied in magnetic resonance measurement, material analysis through resonance, magnetic property measurement, etc., can solve the problems of increased patient diagnosis cost, patient discomfort, prolonged breath-holding time, etc., and shorten the total sampling time. Effect

Active Publication Date: 2018-10-12
WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] In the first case, due to the relaxation loss of the hyperpolarized xenon signal in the process of running the CSSR method, the signal will be too low when running the DWI method
In the second scheme, the signal is too low when running the CSSR method due to the loss of the hyperpolarized xenon signal during the DWI method.
In addition, whether it is the above-mentioned first or second method, continuous operation of the two methods will lead to a prolonged single breath-hold time, causing discomfort to the patient.
In the third option, the patient needs to inhale twice the dose of hyperpolarized xenon gas and hold the gas twice, which increases the time and material costs of collecting hyperpolarized xenon gas, resulting in an increase in patient diagnosis costs and a decrease in diagnostic efficiency.

Method used

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  • A Hyperpolarized Xenon Magnetic Resonance Method Based on Spectrum-Image Integration
  • A Hyperpolarized Xenon Magnetic Resonance Method Based on Spectrum-Image Integration
  • A Hyperpolarized Xenon Magnetic Resonance Method Based on Spectrum-Image Integration

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Experimental program
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Effect test

Embodiment 1

[0053] The present invention is based on the way of spectrum-image integration, and simultaneously completes the operation of the CSSR method and the DWI method in a single sampling. The steps of the present invention are:

[0054] Step 1. Initialize the total number of repetitions m of the CSSR step (chemical shift saturation recovery step), and initialize the preset exchange time τ of the CSSR step (chemical shift saturation recovery step) 1 ~τ m , preset exchange time τ 1 ~τ m The size relationship between is τ 1 2 m ;

[0055] Step 2, initialize the total number of excitations Z of the DWI step (diffusion weighted imaging step), and initialize the repetition time TR of the DWI step (diffusion weighted imaging step);

[0056] Step 3. Determine the preset exchange time τ according to the following formula k Internal energy run DWI step (diffusion weighted imaging step) can run the number of times f k

[0057]

[0058] Among them, the square brackets [] represent t...

Embodiment 2

[0087] Specific values ​​are given below for some set values ​​in Example 1, so as to compare the method of the present invention with the three schemes in the background technology. In this example:

[0088] m=27 set in step 1,

[0089] [τ 1 ,...,τ m ]=[0,10,20,30,40,50,60,70,80,90,100,110,120,130,140,150,160,170,180,190,200,300,400,500,600,700,900] ms;

[0090] Z=192, TR=30ms set in step 2;

[0091] corresponding to step 3

[0092] [f 1 ,..., f m ]=[0,0,0,1,1,1,2,2,2,3,3,3,4,4,4,5,5,5,6,6,6,10,13,16 ,20,23,30];

[0093] corresponding to step 4

[0094] [n 1 ,...,n m ]=[0,0,0,1,1,1,2,2,2,3,3,3,4,4,4,5,5,5,6,6,6,10,13,16 ,20,23,30];

[0095] h=17 corresponding to step 5;

[0096] Corresponding to step 6

[0097] [T 1 ,...,T m ]=[0,10,20,0,10,20,0,10,20,0,10,20,0,10,20,0,10,20,0,10,20,0,10,20 ,0,10,0] ms;

[0098] In this embodiment, the time required to run the saturation step and the spectrum sampling step once in the CSSR method is set as Ty=30ms.

[0099...

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Abstract

The invention relates to a hyperpolarization xenon magnetic resonance method based on spectrum image integration. The method comprises the following steps: through a CSSR step for excitation of hyperpolarization dissolved-state xenon, acquiring a magnetic resonance spectrogram, and through a DWI step for excitation of hyperpolarization gaseous-state xenon, acquiring a magnetic resonance image; when preset exchange time in the CSSR step is greater than repeated time of the DWI step, running the DWI step in the preset exchange time; filling a first data space with data obtained through the CSSR step, and filling a second data space with data obtained through the DWI step; and obtaining the magnetic resonance spectrogram by performing one-dimensional fast Fourier transformation on the data in the first data space, and obtaining the magnetic resonance image by successively performing two-dimensional fast Fourier transformation after the data in the second data space is rearranged. According to the method, "gas diffusion" and "qi and blood exchange" function information of hyperpolarization xenon in a lung can be obtained more quickly through synchronous acquisition.

Description

technical field [0001] The invention relates to the technical field of magnetic resonance imaging, in particular to a hyperpolarized xenon magnetic resonance method based on spectrum-image integration. Suitable for magnetic resonance imaging of the lungs with hyperpolarized xenon gas as a contrast agent. Background technique [0002] With the increase in the number of smokers and the aggravation of air pollution (such as smog, etc.), the situation of lung diseases is getting worse day by day. Chest X-ray (X-ray), computer tomography (Computer Tomography, CT) etc. are current routine clinical imaging diagnostic techniques for lung diseases, but they have certain radioactivity. Relatively speaking, magnetic resonance imaging (Magnetic Resonance Imaging, MRI) technology has no radiation, but the lung is a "blind spot" of conventional MRI. The use of hyperpolarized xenon gas (Xe-129) as a contrast agent is a novel technique that enables MRI of lung structures. Moreover, hyper...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01R33/20
CPCG01R33/20
Inventor 周欣钟俭平张会婷邓鹤孙献平叶朝辉
Owner WUHAN INST OF PHYSICS & MATHEMATICS CHINESE ACADEMY OF SCI
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