Lactic acid bacteria teichoic acid gel for auxiliary therapy of vaginal diseases

A technology for adjuvant therapy and vaginal diseases, which is applied in the directions of sexual diseases, emulsion delivery, medical preparations with inactive ingredients, etc. The effect of avoiding adverse side effects, promoting vaginal mucosal epithelial hyperplasia, and avoiding side effects

Inactive Publication Date: 2016-12-21
张可池
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For patients with bacterial vaginosis, it is necessary to help them restore the dominant flora status of lactic acid bacteria, but th...

Method used

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  • Lactic acid bacteria teichoic acid gel for auxiliary therapy of vaginal diseases
  • Lactic acid bacteria teichoic acid gel for auxiliary therapy of vaginal diseases

Examples

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Effect test

Embodiment 1

[0018] A lactic acid bacteria teichoic acid gel for auxiliary treatment of vaginal diseases, comprising the following raw materials in parts by weight: 3 parts of lactic acid bacteria lipoteichoic acid, 50 parts of maltooligosaccharide, 50 parts of kudzu root powder, 30 parts of hyaluronic acid, 10 parts of glycerin , 5000 parts of distilled water.

[0019] Its preparation steps are as follows:

[0020] (1) Lactobacillus lipoteichoic acid: the lactic acid bacteria liquid was collected by centrifugation, frozen in liquid nitrogen for 1 min, taken out, and left at room temperature for 90 seconds, and thus repeatedly frozen and thawed 4 times to break up the bacteria; add 20 times the volume of the bacteria % phenol aqueous solution was reacted for 5 minutes, then an equivalent amount of 95% phenol aqueous solution was added, and the water bath was kept at 68°C for 30 minutes while stirring continuously; Dialyze for 36 hours; then use distilled water to stand still for dialysis ...

Embodiment 2

[0023] A lactic acid bacteria teichoic acid gel for auxiliary treatment of vaginal diseases, comprising the following raw materials in parts by weight: 1 part of lactic acid bacteria lipoteichoic acid, 10 parts of maltooligosaccharide, 20 parts of kudzu root powder, 5 parts of hyaluronic acid, and 5 parts of glycerin , 500 parts of distilled water.

[0024] Its preparation steps are as follows:

[0025] (1) Lactobacillus lipoteichoic acid: the lactic acid bacteria solution was collected by centrifugation, frozen in liquid nitrogen for 1 min, taken out, and left at room temperature for 90 seconds, repeated freezing and thawing 3 times to break the bacteria; adding 20 times the volume of the bacteria % phenol aqueous solution was reacted for 5 minutes, then an equivalent amount of 95% phenol aqueous solution was added, and the water bath was kept at 68°C for 30 minutes while stirring continuously; Dialyze for 24 hours; then use distilled water to stand still for dialysis for 24...

Embodiment 3

[0028]A lactic acid bacteria teichoic acid gel for auxiliary treatment of vaginal diseases, comprising the following raw materials in parts by weight: 5 parts of lactic acid bacteria lipoteichoic acid, 50 parts of maltooligosaccharide, 100 parts of kudzu root powder, 50 parts of hyaluronic acid, and 10 parts of glycerin , 5000 parts of distilled water.

[0029] Its preparation steps are as follows:

[0030] (1) Lactobacillus lipoteichoic acid: The lactic acid bacteria liquid was collected by centrifugation, frozen in liquid nitrogen for 1 minute, taken out, and left at room temperature for 90 seconds. Repeated freezing and thawing for 5 times to break up the bacteria; adding 20 times the volume of the bacteria % phenol aqueous solution was reacted for 5 minutes, then an equivalent amount of 95% phenol aqueous solution was added, and the water bath was kept at 68°C for 30 minutes while stirring continuously; Dialyze for 48 hours; then use distilled water to stand still for dia...

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Abstract

The invention provides lactic acid bacteria teichoic acid gel for auxiliary therapy of vaginal diseases. The gel is finely prepared from the components including, by weight, 1-5 parts of lactic acid bacteria lipoteichoic acid, 10-50 parts of maltose oligosaccharide, 20-100 parts of kudzu root powder, 5-50 parts of hyaluronic acid, 5-10 parts of glycerin, and 500-5000 parts of distilled water. The lactic acid bacteria lipoteichoic acid in the gel can be adhered to vaginal epithelial cell acceptors to occupy ecological sites, thereby inhibiting adhesion of pathogenic bacteria; meanwhile, the kudzu root powder contains isoflavones that can be combined with steroid estrogen acceptors at low affinity to achieve the functions of the estrogen, thus improving proliferation of vaginal mucosa epithelium and reducing the pH in vagina. The gel has the effects of repairing damaged vagina and improving elasticity.

Description

technical field [0001] The invention relates to a lactic acid bacteria teichoic acid gel used for auxiliary treatment of vaginal diseases, and belongs to the technical field of gynecological medicine. Background technique [0002] The female vagina is a very complex micro-ecological system, which is composed of the anatomical structure of the vagina, micro-ecological flora, local immune system and endocrine regulation functions. Women suffering from vaginal infectious diseases are mainly governed by three factors: etiology, environment and host, but the key lies in the relationship between normal microbial flora and the host. From the perspective of clinical medicine, the relationship between female vaginal microecology and vaginal infection is very close. For now, antibacterial drugs such as metronidazole are effective in treating bacterial vaginosis clinically, but there are still some cases that are resistant to drugs, and the drugs also have certain toxic and side effec...

Claims

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Application Information

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IPC IPC(8): A61K36/488A61K9/06A61K47/36A61K47/10A61K47/26A61P15/02A61K31/80A61K35/744
CPCA61K36/488A61K9/06A61K31/80A61K35/744A61K47/10A61K47/26A61K47/36A61K2300/00
Inventor 张培红张可池
Owner 张可池
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