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Method for manufacturing biodegradable shape-memory polymer intravascular stent additive with negative poisson ratio

A technology of memory polymer and negative Poisson's ratio, applied in stents, additive processing, medical science, etc., can solve problems such as restenosis in stents, and achieve the effects of avoiding axial shrinkage, avoiding positioning, and avoiding damage

Inactive Publication Date: 2016-12-21
JILIN UNIV
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Problems solved by technology

[0006] The purpose of the present invention is to provide a negative Poisson's ratio degradable shape memory polymer vascular stent additive manufacturing method, which solves the problem of in-stent restenosis caused by traditional vascular stents

Method used

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  • Method for manufacturing biodegradable shape-memory polymer intravascular stent additive with negative poisson ratio
  • Method for manufacturing biodegradable shape-memory polymer intravascular stent additive with negative poisson ratio
  • Method for manufacturing biodegradable shape-memory polymer intravascular stent additive with negative poisson ratio

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Embodiment

[0056] A negative Poisson's ratio degradable shape memory polymer vascular stent additive manufacturing method, comprising the following steps:

[0057] (1) Based on the rotating quadrilateral structural unit with negative Poisson's ratio effect, design a three-dimensional structural model of vascular stent with negative Poisson's ratio effect in the radial and axial directions, and design a degradable shape memory polymer blood vessel with negative Poisson's ratio The wall thickness of the bracket is 0.2mm, and the diameter is 4mm;

[0058] (2) Input the designed three-dimensional model of the rotating quadrilateral vascular stent into the additive manufacturing system in STL format, and the system control software performs layered slice processing on the three-dimensional model data, and generates corresponding motion trajectory codes for each layer of data ;

[0059] (3) Using micro-syringe droplet jetting free forming technology, using biodegradable shape memory polymer p...

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Abstract

The invention relates to a method for manufacturing a biodegradable shape-memory polymer intravascular stent additive with a negative poisson ratio. The method comprises the following steps: firstly, designing an intravascular stent original configuration with negative poisson ratio in radial and axial directions based on a negative poisson ratio structural unit; then, manufacturing additive of the biodegradable shape-memory polymer intravascular stent additive with a negative poisson ratio by adopting a micro-droplet jetting additive technology; and finally, testing the performance of the intravascular stent. According to the method, a complex geometric intravascular stent from micro-droplet jetting additive, so that the shape and performance controlling capacity of the intravascular stent can be effectively improved; minimal invasive implantation of the intravascular stent can be realized by utilizing the negative poisson ratio; in the stent expanding process, the vascular wall is uniformly stressed, so that injury can be effectively avoided, and stent migration is avoided due to no axial contraction; and the shape-memory spontaneous gradual expansion and biodegradability of the biodegradable shape-memory polymer intravascular stent can be realized under dynamic excitation, and the problems of in-stent restenosis, taking-out difficulty after implantation and the like can be effectively avoided.

Description

technical field [0001] The invention relates to the technical field of additive manufacturing and the field of degradable shape memory polymer forming, in particular to the cross field of mechanical engineering, tissue engineering, life science and material science, especially to a negative Poisson's ratio degradable shape memory polymer blood vessel Scaffold additive manufacturing method. Background technique [0002] Vascular stent implantation is the most widely used technique with the best effect in the treatment of vascular occlusion diseases, and restenosis is one of the main failure modes of vascular stent implantation. At present, the most commonly used stent type is the balloon-expandable stent. The stent is delivered to the lesion through a balloon catheter, and then the stent is expanded by the pressure of the balloon to release the stent. However, balloon expansion can easily cause elastic retraction of the vessel wall and damage the vessel wall. It leads to neo...

Claims

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Application Information

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IPC IPC(8): A61F2/82B33Y80/00B33Y10/00B33Y70/00
CPCA61F2/82A61F2210/0004A61F2210/0023A61F2210/0038A61F2210/0052A61F2210/0061A61F2230/0063A61F2240/001B33Y10/00B33Y70/00B33Y80/00
Inventor 吴文征武子超耿鹏隋航王博凡刘巍赵继
Owner JILIN UNIV
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