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A method and system for reverse intensity-modulated optimization calculation of afterloading radiotherapy dose

A technology for optimizing calculation and dose, applied in radiation therapy, X-ray/γ-ray/particle irradiation therapy, treatment, etc., can solve problems such as unsatisfactory, difficult to popularize, dose distribution without considering anatomical structure, etc., and achieve the effect of optimizing the gradient

Active Publication Date: 2019-04-16
CANCER CENT OF GUANGZHOU MEDICAL UNIV
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Problems solved by technology

[0003] At present, some brachytherapy planning systems based on CT, MRI, PET and other images have been used clinically, the most representative of which is Oncentra GYN developed by Netherland Nuclear Communication Company, which uses simulated annealing algorithm to realize the afterloading radiotherapy dose. Reverse intensity modulation optimization function, but the systems developed by these foreign companies are expensive and difficult to promote in China
However, most radiotherapy units in China still use the traditional two-dimensional brachytherapy radiotherapy planning system based on X-ray films. The dose distribution does not consider the individual anatomical structure, and it does not have the reverse intensity-modulated optimization function of post-loaded radiotherapy dose. Unable to meet the needs of individualized afterloading radiotherapy

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  • A method and system for reverse intensity-modulated optimization calculation of afterloading radiotherapy dose
  • A method and system for reverse intensity-modulated optimization calculation of afterloading radiotherapy dose
  • A method and system for reverse intensity-modulated optimization calculation of afterloading radiotherapy dose

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specific Embodiment

[0118] S1. Outline the range of the tumor target area on the after-loaded CT image, obtain several images of the tumor target area, and then perform three-dimensional reconstruction of the applicator;

[0119] S2. Calculate all stagnation points on the applicator according to the preset interval ΔL=2.5mm, and activate the stagnation points within the range of the tumor target area;

[0120] S3. Count the number N of activated stationary points and the number M of images of the tumor target area within the range of the tumor target area, and calculate the number of selected dose reference points on each image P=int(N / M);

[0121] S4. Set the maximum search times k of the outer loop max , and set the initial search times k=1;

[0122] S5. In each image of the tumor target area, randomly select P dose reference points; if there is no intersection between the outline of the tumor target area and the outline of the organ at risk, the P dose reference points are all randomly select...

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Abstract

The invention discloses an afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method and system. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method comprises calculating all positions of stationary points on a source applicator and activating stationary points within a tumor target region; calculating the number of dose selection reference points in each image; and working out the optimal stationary point position and residence time through an internal-external double circulation mode. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation system comprises an image generation unit, a stationary point activation unit, a statistics unit and a circulation calculation unit. According to the invention, a customized anatomical structure is taken as the basis, the optimal combination mode of the radioactive source residence position and residence time is obtained by means of an internal-external double circulation searching mode, the customized afterloading radiotherapy dose inverse intensity-modulated optimizing demand can be satisfied, in the external circulation, a primary combination is solved by means of a relaxation method, in the internal circulation, by combining the expected dose of the tumor target region and the constraint dose which is dangerous to organs, the gradient of the stationary point position and the residence time is further optimized. The afterloading radiotherapy dose inverse intensity-modulated optimizing calculation method and system can be widely applied to afterloading radiotherapy dose calculation.

Description

technical field [0001] The invention relates to the field of dose optimization calculation, in particular to a method and system for reverse intensity modulation optimization calculation of afterloading radiotherapy dose. Background technique [0002] Brachytherapy is mainly used in the treatment of cervical cancer, prostate cancer, nasopharyngeal cancer and other tumors, and the curative effect is positive. In recent years, with the development of image-guided radiotherapy technology and source applicators, individualized afterloading therapy has become a current research hotspot, and the intensity-modulated optimization of afterloading radiotherapy dose is the key technology of individualized treatment. The expected dose of the tumor target area and the constrained dose of the organs at risk are reversely searched for an optimal combination of afterloading radiation source residence position and residence time through mathematical algorithms, and the resulting dose distrib...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61N5/10G16H30/40
CPCA61N5/1001A61N5/1031A61N5/1039
Inventor 余辉张书旭蔡隆梅林生趣李慧君张全彬闫微
Owner CANCER CENT OF GUANGZHOU MEDICAL UNIV
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