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Medical antibacterial acupuncture-resistant rubber plug and preparation method thereof

A rubber stopper, antibacterial and resistant technology, applied in the field of medical antibacterial needle-resistant rubber stopper and its preparation, can solve the problems of medical disputes, puncture debris, etc., and achieve the effect of good puncture ability, good product quality and simple process

Active Publication Date: 2016-12-07
烟台鑫汇包装有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are still some problems in the application of butyl rubber stoppers. The most prominent problem is the problem of puncture debris, which has caused medical disputes

Method used

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  • Medical antibacterial acupuncture-resistant rubber plug and preparation method thereof

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Comparison scheme
Effect test

Embodiment 1

[0019] A medical antibacterial and needle-resistant rubber stopper, prepared from the following ingredients in parts by weight: 120 parts of bromobutyl rubber, 1.5 parts of hard ester, 5 parts of zinc oxide, 0.2 part of sulfur, 6 parts of titanium dioxide, and 70 parts of calcined kaolin 0.1 part of accelerator ZDC, 0.5 part of accelerator DM, 0.8 part of 2-mercaptobenzimidazole, 20 parts of ethylene-ethyl acrylate copolymer, styrene-isoprene-styrene triblock copolymer 10 parts, 0.5 parts of galangal extract, 1.5 parts of calamus extract.

[0020] The preparation method of the above-mentioned medical antibacterial needle-resistant rubber stopper is as follows: (1) take galangal medicinal material and grind it, extract it with 80% ethanol under reflux, extract the extract with petroleum ether, chloroform, ethyl acetate respectively, after obtaining the active part, use silica gel The chemical components were separated and purified by column chromatography to obtain galangal ext...

Embodiment 2

[0022] A medical antibacterial and needle-resistant rubber stopper, prepared from the following ingredients in parts by weight: 90 parts of bromobutyl rubber, 0.5 parts of hard ester, 2 parts of zinc oxide, 0.15 parts of sulfur, 10 parts of titanium dioxide, and 90 parts of calcined kaolin 1 part, 1 part of accelerator ZDC, 0.1 part of accelerator DM, 0.3 parts of 2-mercaptobenzimidazole, 10 parts of ethylene-ethyl acrylate copolymer, styrene-isoprene-styrene triblock copolymer 20 parts, galangal extract 1.5 parts, calamus extract 0.5 parts.

[0023] The preparation method of the above-mentioned medical antibacterial needle-resistant rubber stopper is as follows: (1) take galangal medicinal material and grind it, extract it with 80% ethanol under reflux, extract the extract with petroleum ether, chloroform, ethyl acetate respectively, after obtaining the active part, use silica gel The chemical components were separated and purified by column chromatography to obtain galangal ...

Embodiment 3

[0025] A medical antibacterial and needle-resistant rubber stopper, prepared from the following ingredients in parts by weight: 100 parts of bromobutyl rubber, 1.4 parts of hard ester, 3 parts of zinc oxide, 0.18 parts of sulfur, 8 parts of titanium dioxide, and 80 parts of calcined kaolin 0.5 parts of accelerator ZDC, 0.4 parts of accelerator DM, 0.8 parts of 2-mercaptobenzimidazole, 15 parts of ethylene-ethyl acrylate copolymer, styrene-isoprene-styrene triblock copolymer 18 parts, galangal extract 1.4 parts, calamus extract 0.8 parts.

[0026] The preparation method of the above-mentioned medical antibacterial needle-resistant rubber stopper is as follows: (1) take galangal medicinal material and grind it, extract it with 80% ethanol under reflux, extract the extract with petroleum ether, chloroform, ethyl acetate respectively, after obtaining the active part, use silica gel The chemical components were separated and purified by column chromatography to obtain galangal extr...

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Abstract

The invention provides a medical antibacterial acupuncture-resistant rubber plug and a preparation method thereof. The rubber plug is prepared from brominated butyl rubber, hard acid ester, zinc oxide, sulphur, titanium dioxide, calcined kaolin, accelerant ZDC, accelerant DM, 2-mercapto benzimidazole, ethylene-ethyl acrylate copolymer, styrene-isoprene-styrene triblock copolymer, rhizoma alpiniae officinarum extracts and rhizoma acori tatarinowii extracts. The rubber plug is prepared through mixing, rolling forming, vulcanizing, trimming, cleaning, sterilizing and drying. The medical antibacterial acupuncture-resistant rubber plug has a low puncture exfoliation rate and a good puncture capacity, and meanwhile the rubber plug has good antibacterial activity.

Description

technical field [0001] The invention relates to the field of medical rubber materials, in particular to a medical antibacterial and needle-resistant rubber stopper and a preparation method thereof. Background technique [0002] Medical rubber stoppers require rubber materials that are non-toxic, odorless, tasteless, and extract-free, resistant to pharmaceutical chemicals, and can withstand repeated heating and disinfection, good self-sealing, acupuncture resistance, low air permeability, and water permeability. Due to the advantages of good air tightness, heat resistance, acid and alkali resistance, and chemical inertness, butyl rubber stoppers soon replaced natural rubber stoppers in the field of pharmaceutical packaging. At present, more than 90% of rubber stoppers for pharmaceutical packaging are produced with butyl rubber as the base material. However, there are still some problems in the application of butyl rubber stoppers. The most prominent problem is the problem of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08L15/02C08L23/08C08L53/02C08K13/02C08K3/22C08K3/34C08K5/00C08K3/06B29C35/02
CPCB29C35/02C08L15/02C08L2203/02C08L2205/03C08L23/0869C08L53/02C08K13/02C08K2003/2296C08K2003/2241C08K3/346C08K5/0058Y02P20/54
Inventor 樊之雄
Owner 烟台鑫汇包装有限公司
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