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Novel pH-response composite hydrogel containing rare earth complex and preparation method and application of novel pH-response composite hydrogel

A rare earth complex and composite hydrogel technology, applied in chemical instruments and methods, organic chemistry, instruments, etc., can solve problems such as alginate and agar rare earth complexes that have not been reported yet.

Active Publication Date: 2016-12-07
睿得新材料科技(佛山)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] At present, no research has reported alginate and agar as a mixed carrier for rare earth complexes

Method used

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  • Novel pH-response composite hydrogel containing rare earth complex and preparation method and application of novel pH-response composite hydrogel
  • Novel pH-response composite hydrogel containing rare earth complex and preparation method and application of novel pH-response composite hydrogel
  • Novel pH-response composite hydrogel containing rare earth complex and preparation method and application of novel pH-response composite hydrogel

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Embodiment 1

[0074] The embodiment of the present invention provides a preparation method of hydrogel microspheres containing europium-orbifloxacin complex, comprising the following steps:

[0075] (1) According to the molar ratio of europium element in europium oxide to chlorine element in concentrated hydrochloric acid being 1:8, weigh Eu 2 o 3 In a beaker, add concentrated hydrochloric acid to dissolve it completely, stop after heating and stirring to evaporate excess water and hydrochloric acid, and then obtain EuCl after cooling and crystallization 3 ·6H 2 O standby;

[0076] (2) Get 6mmol Obifloxacin and EuCl prepared by 2mmol step (1) 3 ·6H 2 O is dissolved in 30ml deionized water, and continuously dissolves under magnetic stirring at 300r / min; precipitation), stirred at room temperature for 2 hours, centrifuged, washed twice with absolute ethanol, and dried in an oven at 60°C for 24 hours to obtain 157 mg of the intermediate product europium-orbifloxacin complex;

[0077] (3)...

Embodiment 2

[0090] The embodiment of the present invention provides a preparation method of hydrogel microspheres containing europium-orbifloxacin complex, comprising the following steps:

[0091] (1) According to the molar ratio of europium element in europium oxide to chlorine element in concentrated hydrochloric acid being 1:8, weigh Eu 2 o 3 In a beaker, add concentrated hydrochloric acid to dissolve it completely, stop after heating and stirring to evaporate excess water and hydrochloric acid, and then obtain EuCl after cooling and crystallization 3 ·6H 2 O standby;

[0092] (2) Get 6mmol Obifloxacin and EuCl prepared by 2mmol step (1) 3 ·6H 2 O was dissolved in 30ml of deionized water, and continuously dissolved under magnetic stirring at 250r / min; then the pH value of the solution was adjusted to 7 with dilute ammonia water with a mass fraction of ammonia of 25% (you can see that there is a yellow precipitate), room temperature After stirring at 250r / min for 1.5 hours, centrif...

Embodiment 3

[0096] The embodiment of the present invention provides a preparation method of hydrogel microspheres containing europium-orbifloxacin complex, comprising the following steps:

[0097] (1) According to the molar ratio of europium element in europium oxide to chlorine element in concentrated hydrochloric acid being 1:8, weigh Eu 2 o 3 In a beaker, add excess concentrated hydrochloric acid to dissolve it completely, stop after heating and stirring to evaporate excess water and hydrochloric acid, and obtain EuCl after cooling and crystallization 3 ·6H 2 O standby;

[0098] (2) Get 6mmol Obifloxacin and EuCl prepared by 2mmol step (1) 3 ·6H 2 O was dissolved in 30ml of deionized water, and was continuously dissolved under magnetic stirring at 350r / min; then the pH value of the solution was adjusted to 8 with dilute ammonia water with a mass fraction of ammonia of 25% (it can be seen that yellow precipitates were separated out), at room temperature After stirring at 350r / min f...

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Abstract

The invention provides novel pH-response composite hydrogel containing rare earth complex and a preparation method and application of the novel pH-response composite hydrogel. The novel pH-response composite hydrogel containing the rare earth complex is in a shape similar to a sphere, and the particle diameter is 3-5mm. The novel pH-response composite hydrogel containing the rare earth complex is prepared from the rare earth complex and composite hydrogel coated with the rare earth complex. The novel pH-response composite hydrogel containing the rare earth complex can improve luminescent performance, light stability, thermal stability and chemical stability of the rare earth complex, has the characteristic of being good in biological compatibility and degradability, and the like, and also has the advantages of being high in flexibility, short in time and reusable.

Description

technical field [0001] The invention belongs to the technical field of luminescent materials, and specifically relates to a novel pH-responsive composite hydrogel containing rare earth complexes, a preparation method and application thereof. Background technique [0002] Due to the unique electron layer structure of rare earth ions, the luminescence of rare earth has the advantages of high quantum yield, long fluorescence lifetime, narrow emission band, and large Stokes shift. And rare earth fluorescence can generate corresponding signal responses to specific analytes including anions and cations, proteins, DNA, pH value, temperature, biomarkers, etc. Therefore, rare earth luminescent materials have been widely used as optical sensors in chemistry and biology. analyze. [0003] Although rare earth complexes have excellent luminescent properties, they have the huge defect of poor light and thermal stability, which seriously limits their practical application value and scope....

Claims

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Application Information

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IPC IPC(8): C07D401/04C07D215/56C09K11/06G01N21/64
CPCC07D215/56C07D401/04C09K11/06C09K2211/182G01N21/6428
Inventor 苏荣杨京莲郑玉惠王前明
Owner 睿得新材料科技(佛山)有限公司
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