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A method for ultrasonic-water extraction of scutellarin from scutellaria plants

A technology of scutellarin and scutellaria scutellarin, which is applied in chemical instruments and methods, sugar derivatives, sugar derivatives, etc., can solve the problems of solvent residual environment, low extraction efficiency, and high solvent cost, and achieves a simple and convenient waste liquid treatment method. The effect of extracting less impurities and reducing the extraction cost

Active Publication Date: 2018-08-03
BEIJING LUORUI BIOLOGICAL TECH CO LTD
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Problems solved by technology

[0007] The purpose of the present invention is to provide a fast, efficient and safe extraction method from Erigeron breviscapus for the problems of high solvent cost, large dosage, low extraction efficiency, environmental pollution caused by solvent residue, and large-scale production safety in the existing extraction method. A New Approach to Scutellarin

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  • A method for ultrasonic-water extraction of scutellarin from scutellaria plants

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example 1

[0019] Take 100.0 grams of the whole herb of scutellaria breviscapus (the content of scutellarin is 3.14%), and grind it to 20 mesh. Add 4.0 liters of water, the water temperature is controlled at 50°C, conduct ultrasonic extraction for 1 hour, filter and centrifuge the scutellaria breviscapus water extract to obtain the scutellaria breviscapus water extract. The water extract of scutellaria scutellaria was adsorbed to saturation with AB-8 resin, and the adsorption column was desorbed with acetic acid-ethanol solution to obtain the eluent, which was concentrated under reduced pressure to obtain 9.3 grams of scutellarin crude extract, the content of which was 28.9% (HPLC).

example 2

[0021] Take 5.0 kg of the whole herb of scutellaria breviscapus (the content of scutellarin is 3.48%), and grind it to 40 mesh. Add 200.0 liters of water, control the water temperature at 55°C, conduct ultrasonic extraction for 1 hour, then filter and centrifuge the water extract of scutellaria breviscapus to obtain the water extract of scutellaria breviscapus. The water extract of scutellaria scutellaria was adsorbed to saturation with D101 resin, and the adsorption column was desorbed with acetic acid-ethanol solution to obtain the eluate, which was concentrated under reduced pressure to obtain 540.1 g of scutellarin crude extract, with a scutellarin content of 28.3% (HPLC).

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Abstract

The invention relates to the technical field of scutellarin extraction, specifically a method for obtaining crude scutellarin after pulverizing dried whole herb of scutellaria breviscapus, ultrasonic-water solution extraction, macroporous adsorption resin adsorption, organic solvent elution, and concentration under reduced pressure. The extraction process is as follows: 1. After the dried whole herb of Erigeron breviscapus is crushed, mixed with water solvent, and subjected to ultrasonic extraction process, the water extract of Erigeron breviscapus is obtained; 2. After the extract is filtered and centrifuged, it is directly absorbed by macroporous resin, Eluted and concentrated to obtain crude scutellarin. The method utilizes ultrasonic-water technology to extract scutellarin, which replaces the organic solvent extraction and can still achieve the same yield. The cost of the solvent is low, the safety is high, and there is no environmental pollution; Concentrate under pressure to obtain crude scutellarin with higher content.

Description

technical field [0001] The invention relates to the technical field of extraction of scutellarin, in particular to the ultrasonic extraction technology of aqueous solution of scutellarin. Background technique [0002] Erigeron breviscapus, also known as Erigeron breviscapus, is the dry whole herb of Asteraceae breviscapita, mainly distributed in Southwest China, and is a commonly used traditional Chinese medicine. Scutellarin has various pharmacological effects, such as dilating cerebral blood vessels and coronary vessels, improving microcirculation, inhibiting platelet aggregation, anticoagulation, anti-myocardial infarction, preventing cerebral hypoxia and renal failure, etc. Clinically, it is mainly used to treat paralysis after stroke, coronary heart disease, etc. People have isolated and identified a variety of chemical components from Breviscapus, including flavonoids, benzoic acids, caffeoylquinic acids, γ-pyrone, terpenes, essential oils, etc., and have determined t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/07C07H1/08
Inventor 夏传递肖虎王惠芳焦燕玲
Owner BEIJING LUORUI BIOLOGICAL TECH CO LTD
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