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Method for preparing gadolinium hydroxide nanorod with cerebral glioma targeting function

A brain glioma and gadolinium hydroxide technology, applied in the field of nanomaterials, can solve the problem of small size and achieve the effect of uniform size, good relaxation effect and simple process

Inactive Publication Date: 2016-11-23
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Retrieval of relevant literature and patents at home and abroad shows that there is no one-step hydrothermal method to prepare small and uniform Gd(OH) 3 Nanorods modified with targeting peptides on their surface for in vivo brain glioma targeting and T 1 Research Report on Contrast Enhancement of Magnetic Resonance Imaging

Method used

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  • Method for preparing gadolinium hydroxide nanorod with cerebral glioma targeting function
  • Method for preparing gadolinium hydroxide nanorod with cerebral glioma targeting function
  • Method for preparing gadolinium hydroxide nanorod with cerebral glioma targeting function

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Dissolve 2.2568g gadolinium nitrate hexahydrate in 100mL deionized water, stir to form a uniform gadolinium nitrate solution, then add 1mmol / mL sodium hydroxide aqueous solution dropwise to the above-mentioned gadolinium salt solution and stir to adjust the pH to 13. Gadolinium hydroxide nanoparticles, continue to stir for a few minutes, place the reacted mixed solution A in a high-pressure reactor, and then react in an electric thermostat reaction oven at 180°C for 12 hours to obtain a white precipitate powder, and centrifuge the obtained white precipitate. Then wash three times with deionized water, and dry under vacuum at room temperature to obtain well-dispersed gadolinium hydroxide nanorods (i.e. Gd(OH) 3 NRs); ultrasonically disperse 200 mg of gadolinium hydroxide nanorods in 50 mL of a mixture of dimethyl sulfoxide and carbon tetrachloride B, then add 1 mL of aminopropyltriethoxysilane and 30 μL of deionized water in sequence, and the resulting mixture C stirred...

Embodiment 2

[0030] Dissolve 4.5136g gadolinium nitrate hexahydrate in 100mL deionized water, stir and disperse to form a uniformly dispersed gadolinium nitrate solution, then add 1mmol / mL sodium hydroxide aqueous solution dropwise to the above-mentioned gadolinium salt solution and stir to adjust the pH to 13, after the reaction Transform into gadolinium hydroxide nanoparticles, continue to stir for a few minutes, place the reacted mixed solution A in a high-pressure reactor, and then react in an electric constant temperature drying oven at 160°C for 12 hours to obtain a white precipitated powder, which is then centrifuged. and washed three times with deionized water, and dried under vacuum at room temperature to obtain well-dispersed gadolinium hydroxide nanorods (Gd(OH) 3 NRs); ultrasonically disperse 200 mg of gadolinium hydroxide nanorods in 50 mL of a mixture of dimethyl sulfoxide and carbon tetrachloride B, then add 1 mL of aminopropyltriethoxysilane and 30 μL of deionized water in s...

Embodiment 3

[0032] Dissolve 2.2568g gadolinium nitrate hexahydrate in 100mL deionized water, stir and disperse to form a uniformly dispersed gadolinium nitrate solution, then add 1mmol / mL sodium hydroxide aqueous solution dropwise to the above-mentioned gadolinium salt solution and stir to adjust the pH to 13, after the reaction Transform into gadolinium hydroxide nanoparticles, continue to stir for a few minutes, place the reacted mixed solution A in a high-pressure reactor, and then react in an electric constant temperature drying oven at 180°C for 6 hours to obtain a white precipitated powder, which is then centrifuged. and washed three times with deionized water, and dried under vacuum at room temperature to obtain well-dispersed gadolinium hydroxide nanorods (i.e. Gd(OH) 3 NRs); ultrasonically disperse 200 mg of gadolinium hydroxide nanorods in 50 mL of a mixture of dimethyl sulfoxide and carbon tetrachloride B, then add 1 mL of aminopropyltriethoxysilane and 30 μL of deionized water ...

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Abstract

The invention discloses a method for preparing a gadolinium hydroxide nanorod with a cerebral glioma targeting function. The method comprises the following steps: reacting a gadolinium salt reaction and strong alkali liquid to produce gadolinium hydroxide nanoparticles, and carrying out a high-temperature hydrothermal reaction, thereby obtaining the gadolinium hydroxide nanorod; performing amination and dual-function pegylation on the gadolinium hydroxide nanorod, and adding thiolated cyclic arginine, glycine and aspartic acid peptide oligopeptide (HS-cRGD) to react and connect, thereby obtaining the RGD peptide modified gadolinium hydroxide nanorod product. The method disclosed by the invention is mild in reaction process conditions and easy to master and operate, and the product has high biocompatibility, in-vivo degradability, magnetic resonance imaging T1 contrast enhancement effect and cerebral glioma targeting function.

Description

technical field [0001] The invention relates to the technical field of nanomaterials, in particular to a preparation method of gadolinium hydroxide nanorods with brain glioma targeting function. Background technique [0002] Brain glioma is the most common type of intracranial tumors, accounting for about 32% to 61% of intracranial tumors. At present, there is still no effective treatment for glioma, and the overall prognosis is poor. The characteristics of invasion and distant metastasis make it easy to relapse. The therapeutic effect and cost of tumors are closely related to the period of disease discovery, so early diagnosis of tumors is the key to treatment. Molecular imaging is the qualitative and quantitative analysis of organisms at the cellular and molecular levels in a living state. It can detect the molecular biological characteristics of lesions, such as precancerous molecular changes, gene changes, etc., in the early stage of tumors before clinical symptoms appe...

Claims

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Application Information

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IPC IPC(8): A61K49/18C01F17/00B82Y30/00
CPCA61K49/186A61K49/1866B82Y30/00C01P2004/04C01P2004/16C01F17/206
Inventor 黄忠兵蔡变云尹光福廖晓明蒲曦鸣
Owner SICHUAN UNIV
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