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Application of cs-zno as an immune enhancer for piglet intestinal mucosa

A technology of immune enhancer and intestinal mucosa, which is applied in the application field of compound in livestock and poultry feed, can solve the problems of low absorption rate and utilization rate of inorganic zinc, resource waste environment, excessive zinc content, etc., and achieve the goal of improving daily growth weight loss, relieve inflammatory response, and reduce the content of pro-inflammatory factors

Active Publication Date: 2019-11-05
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Extensive use of zinc oxide has resulted in excessive zinc content in feces, causing pollution to the environment
[0005] Diarrhea in weaned piglets has always been a worldwide problem. Although a high dose of zinc oxide of 3 000 mg / kg can better control the diarrhea rate of weaned piglets, the absorption rate and utilization rate of inorganic zinc are low, and more than 90% of zinc is excreted with feces , causing waste of resources and environmental pollution

Method used

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  • Application of cs-zno as an immune enhancer for piglet intestinal mucosa
  • Application of cs-zno as an immune enhancer for piglet intestinal mucosa
  • Application of cs-zno as an immune enhancer for piglet intestinal mucosa

Examples

Experimental program
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Effect test

Embodiment 1

[0015] In this experiment, 90 piglets with a body weight of 5.5 kg and weaned at 21 days were randomly divided into 3 groups (3 replicates in each group, 10 pigs in each replicate), and were randomly divided into 3 groups according to the requirements of the feeding experiment. . Three different diets were tested, the control group was corn-soybean meal based diet, and the experimental group was added 100mg / kg chitosan-zinc oxide complex (CS-ZnO) and 100mg / kg shell Polysaccharide and zinc oxide mixture (CS+ZnO, the mass ratio of CS to ZnO is 1:2), the above additions are calculated as zinc, and the basic diet is prepared according to the nutritional requirements of piglets in the United States NRC (1998). The experimental pigs were group-fed in pens and had free access to food and water. Before the test, the pig house was sterilized with 1% Disinfectant, the pre-test period was 7 days, and the main test period was 28 days. During the test, the feed consumption was recorded e...

Embodiment 2

[0022] In this experiment, 90 piglets with a body weight of 6.0 kg and weaned at 24 days were randomly divided into 3 groups (3 replicates in each group, 10 pigs in each replicate), and were randomly divided into 3 groups according to the requirements of the feeding experiment. . Three different rations were tested, the control group was corn-soybean meal basal ration, and the experimental group added 250mg / kg chitosan-zinc oxide complex (CS-ZnO) and 250mg / kg shell Polysaccharide and zinc oxide mixture (CS+ZnO, the mass ratio of CS to ZnO is 1:2), the above additions are calculated as zinc, and the basic diet is prepared according to the nutritional requirements of piglets in the United States NRC (1998). The experimental pigs were group-fed in pens and had free access to food and water. Before the test, the pig house was sterilized with 1% Disinfectant, the pre-test period was 7 days, and the main test period was 28 days. During the test, the feed consumption was recorded e...

Embodiment 3

[0030]In this experiment, 90 piglets with a body weight of 6.5 kg and weaned at 28 days were selected and randomly divided into 3 groups (3 replicates in each group, 10 pigs in each replicate). They were randomly divided into 3 groups according to the requirements of the feeding experiment. . Three different rations were tested, the control group was corn-soybean meal basal ration, and the experimental group added 600mg / kg chitosan-zinc oxide complex (CS-ZnO) and 600mg / kg shell Polysaccharide and zinc oxide mixture (CS+ZnO, the mass ratio of CS to ZnO is 1:2), the above additions are calculated as zinc, and the basic diet is prepared according to the nutritional requirements of piglets in the United States NRC (1998). The experimental pigs were group-fed in pens and had free access to food and water. Before the test, the pig house was sterilized with 1% Disinfectant, the pre-test period was 7 days, and the main test period was 28 days. During the test, the feed consumption w...

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Abstract

The invention discloses application of CS-ZnO as weaned piglet intestinal mucosa immunopotentiator, the CS-ZnO can be used for improving the immunocompetence of the weaned piglet intestinal immunity and reducing the weaned piglet diarrhea rate, and the weaned piglet diarrhea rate is reduced by 8.7%-63.8%. The method comprises the steps that a CS-ZnO compound is directly added to livestock feed, and the mixture is fed to animals after being mixed uniformly, wherein the mass percentage of the CS-ZnO compound takes up 0.01%-0.06% of the added livestock feed; the additive amount is calculated by zinc.

Description

technical field [0001] The invention relates to the application of a compound in livestock and poultry feed, in particular to the application of the CS-ZnO compound as an immune enhancer for intestinal mucosa of weaned piglets. Background technique [0002] CS-ZnO (chitosan zinc oxide) complex is a compound in which chitosan and zinc oxide are dissolved in acid and spray-dried into small particle shapes. The compound has both biocompatibility and strong antibacterial properties. It is a hygienic antibacterial material with great practical value and broad application prospects. However, it has not been reported as an immune enhancer for intestinal mucosa of weaned piglets. [0003] Chitosan is the product of deacetylation of chitin, which is the second largest polymer on earth after cellulose. Chitosan has the characteristics of non-toxicity, good biocompatibility, biodegradability and absorbability, and is widely used in medicine, chemical industry, agriculture and so on. ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23K50/30A23K50/60A23K20/163A23K20/20A61K33/30A61P29/00A61P37/04A61P1/12A61P31/02A61K31/722
CPCA61K31/722A61K33/30A61K2300/00
Inventor 韩新燕扶雄锋孙时军李俊婷
Owner ZHEJIANG UNIV
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