Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Scar removing composition and dressing

A composition and technology for removing scars, applied in the field of biomedicine, can solve problems such as skin damage

Inactive Publication Date: 2016-11-16
GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
View PDF8 Cites 9 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Scar removal can be achieved through drugs, laser or surgery. Surgical laser methods have certain risks. Most of the drug scar removal products on the market currently use some organic macromolecular chemical products containing benzene rings or add some hormones to enhance the scar removal effect. Scar effect, such as the Chinese patent with the publication number CN105055235A, which uses chemical substances such as simethicone, paraben, and triethanolamine, which inevitably has certain damage to the skin

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Scar removing composition and dressing

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0068] 1. Collection of Stem Cell Conditioned Medium

[0069] Take the umbilical cord mesenchymal stem cells of the P3 generation and culture them with DMEM / F12+10% FBS. When the cells are in the exponential growth phase and the confluence reaches 80%, remove the culture supernatant, wash twice with PBS, and add 0.15ml / cm 2 After the phenol red-free 1640 was cultured for 72 hours, the conditioned medium was collected, and the collected conditioned medium was centrifuged at 300 g for 5 minutes, and the supernatant was taken and passed through a 0.22 μm filter membrane to obtain the stem cell conditioned medium for future use.

[0070] 3D printed dressing

[0071] 2.3D modeling

[0072] Use the built-in laser of the 3D printer to scan the surface of the patient's scar to obtain data such as the size, shape, thickness of the wound, and the thickness of the epidermis and dermis of the patient's normal skin. Edit to make it produce a continuous surface image; use Studio4.0 softwa...

Embodiment 2

[0096] 1. Collection of stem cell conditioned medium

[0097] Take P3 generation umbilical cord mesenchymal stem cells and culture them with DMEM / F12+10% FBS. When the cells are in the exponential growth phase and the confluence reaches 80%, remove the culture supernatant, wash twice with PBS, and add 0.10ml / cm 2 After the phenol red-free 1640 was cultured for 72 hours, the conditioned medium was collected, and the collected conditioned medium was centrifuged at 200 g for 5 minutes, and the supernatant was taken, passed through a 0.22 μm filter membrane, and the resulting medium was the stem cell conditioned medium for use.

[0098] 3D printed dressing

[0099] 2. 3D modeling

[0100] Use the built-in laser of the 3D printer to scan the surface of the patient's scar to obtain data such as the size, shape, thickness of the wound, and the thickness of the epidermis and dermis of the patient's normal skin. Edit to make it produce a continuous surface image; use Studio4.0 softwa...

Embodiment 3

[0109] 1. Collection of stem cell conditioned medium

[0110] Take the umbilical cord mesenchymal stem cells of the P3 generation and culture them with DMEM / F12+10% FBS. When the cells are in the exponential growth phase and the confluence reaches 80%, remove the culture supernatant, wash twice with PBS, and add 0.2ml / cm 2 After the phenol red-free 1640 was cultured for 72 hours, the conditioned medium was collected, and the collected conditioned medium was centrifuged at 400 g for 5 minutes, and the supernatant was taken, passed through a 0.22 μm filter membrane, and the resulting medium was the stem cell conditioned medium for use.

[0111] 3D printed dressing

[0112] 2. 3D modeling

[0113] Use the built-in laser of the 3D printer to scan the surface of the patient's scar to obtain data such as the size, shape, thickness of the wound, and the thickness of the epidermis and dermis of the patient's normal skin. Edit to make it produce a continuous surface image; use Studio...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides scar removing composition and a dressing comprises a mesenchymal stem cell extract, a fibroblast growth factor and an aloe extract, wherein the mass concentration of the fibroblast growth factor is 10-50 ng / mL, and the mass fraction of the aloe extract is 0.1%-1%; a mesenchymal stem cell culture solution is obtained through sequential culture of P1-P5 generations of mesenchymal stem cells with a mixed culture medium and a phenol-red-free culture medium; the mixed culture medium comprises a DMEM / F12 culture medium and fetal calf serum. The aloe extract is prepared with the following method: epidermis and mesophyll of fresh leaves of aloe vera are separated, then gel juice is squeezed from the mesophyll and sequentially sterilized, concentrated and freeze-dried, and the aloe extract is obtained. The scar removing composition adopts the mesenchymal stem cell culture solution, is low in immunogenicity and harmless to human bodies, is matched with the fibroblast growth factor and the aloe extract and can fade scars and repair skin wound surfaces.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and in particular relates to a scar-removing composition and a dressing. Background technique [0002] The acne scars left by puberty leave an indelible "mark of youth". With the progress of modern society, love of beauty not only represents a kind of right, but also a kind of respect for self. How to dilute this unpleasant "imprint of youth" has become a topic of concern to many beauty lovers. [0003] Scar removal can be achieved through drugs, laser or surgery. Surgical laser methods have certain risks. Most of the drug scar removal products on the market currently use some organic macromolecular chemical products containing benzene rings or add some hormones to enhance the scar removal effect. Scar effect, such as the Chinese patent whose publication number is CN105055235A, has adopted chemical substances such as simethicone, paraben and triethanolamine, which inevitably has certain dama...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K38/18A61P17/02A61L15/32A61L15/28A61L15/44A61K35/28A61K36/896A61K36/886
CPCA61K35/28A61K36/886A61K36/896A61K38/1825A61L15/28A61L15/325A61L15/44A61L2300/252A61L2300/30A61L2300/414A61L2300/45A61K2300/00C08L89/00C08L5/08C08L5/00
Inventor 陈海佳葛啸虎王一飞麦锦连王小燕
Owner GUANGZHOU SALIAI STEMCELL SCI & TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com