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Application of purslane total flavonoids to preparation of hypoglycemic drugs

A technology of purslane and total flavonoids, which is applied in the preparation of drugs for preventing and treating type 2 diabetes by total flavonoids of purslane, and in the field of medicinal use of total flavonoids of purslane, a traditional Chinese medicine, which can solve problems such as lack of drugs

Inactive Publication Date: 2016-11-16
CHANGCHUN UNIV OF CHINESE MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The invention provides an application of total flavonoids of purslane in the preparation of hypoglycemic drugs, which has solved the problem of lack of related drugs in the current treatment of chronic obstructive pulmonary disease

Method used

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  • Application of purslane total flavonoids to preparation of hypoglycemic drugs
  • Application of purslane total flavonoids to preparation of hypoglycemic drugs
  • Application of purslane total flavonoids to preparation of hypoglycemic drugs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1 preparation method of total flavonoids of purslane

[0015] Purslane was washed with water to remove soil and foreign matter, and 80% ethanol with 8 times the volume was heated and refluxed for 3 times, each time for 3 hours, the extracts were combined for 3 times, the solvent was recovered under reduced pressure to obtain a thick paste, and the purslane was taken. Medicinal material 300g (total flavonoid content is 5.0%, 1500mg), add water to disperse and dissolve, macroporous adsorption resin (D101 macroporous adsorption resin) is applied to the filtrate, after water elution, with 80% ethanol elution (flow velocity 5ml / min), The ethanol eluate was collected sequentially, the amount of eluent was set to be 5 times that of the ethanol extract of purslane, the recovered ethanol was dried under pressure to obtain the total flavonoids extract of purslane.

Embodiment 2

[0016] Embodiment 2 hypoglycemic experimental research

[0017] For hyperglycemic Wistar rats in the model group, positive drug control group, and high, medium, and low dosage administration groups, 0.72g / kg, 0.36g / kg, and 0.18g / kg of Purslane Xiaoke Capsules were used, The administration was continued for four weeks, blood glucose and body weight were measured once a week, and the animals were sacrificed after the fourth week of administration, and blood was collected to measure blood biochemical indicators, blood routine and hemorheology indicators.

[0018] 1. Effects on blood sugar In the third week and fourth week after administration, the blood sugar of Xiaoke Pill group and Purslane Xiaoke Capsule group decreased gradually, showing a certain dose-effect relationship. Scientific significance (P<0.001, P<0.01, P<0.05), see Table 1.

[0019] Table 1 Effect of Purslane Xiaoke Capsules on blood sugar level (mmol / L) of hyperglycemia model rats

[0020]

[0021] Compare...

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Abstract

The invention provides application of purslane total flavonoids to preparation of hypoglycemic drugs, and belongs to the field of modern medicine. For the preparation of medicaments for the treatment of type II diabetes, the purslane total flavonoids are safe for oral administration; and the purslane total flavonoids are formed together with a solid excipient in the preparation of a medicament for treating diseases of type II diabetes. The purslane total flavonoids can decrease the blood glucose level of animals in a wistar rat hyperglycemia model, have significant differences compared with the model group, and can reduce whole blood high shear ratio viscosity, whole blood low shear ratio viscosity and plasma viscosity in blood rheology, have statistical significance. The purslane total flavonoids can be used for the preparation of antidiabetic drugs.

Description

technical field [0001] The invention belongs to the field of modern Chinese pharmacy, and in particular relates to the medicinal use of the total flavonoids of purslane, a traditional Chinese medicine, in particular to the application of the total flavonoids of purslane in the preparation of drugs for preventing and treating type two diabetes. Background technique [0002] Diabetes (diabetes) traditional Chinese medicine called "diabetes" is caused by genetic factors, immune dysfunction, microbial infection and its toxins, free radical toxins, mental factors and other pathogenic factors acting on the body to cause hypofunction of pancreatic islets, insulin A series of metabolic disorder syndromes such as sugar, protein, fat, water and electrolytes caused by resistance, etc. Clinically, hyperglycemia is the main feature. Typical cases may show polyuria, polydipsia, polyphagia, weight loss, etc., that is, " If diabetes (blood sugar) is not well controlled, it will cause compli...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61P3/10
CPCA61K36/185A61K2236/333A61K2236/39A61K2236/55
Inventor 高红梅崔健陈新于秀华
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
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