Lithium reagent composition, lithium ion measurement method and measurement device using the composition

Abstract

The present invention provides a lithium reagent composition, using the lithium ion assay method and assay device with the composition, which can quantitatively measure living body samples or environmental samples more quickly by using a simple colorimeter or an ultraviolet-visible spectrophotometer Lithium in aqueous solution, and can be used to quantify the lithium concentration that can be judged visually. The present invention provides a lithium reagent composition, a lithium ion measurement method and a measurement device using the composition, which will be represented by a structural formula in which all hydrogen atoms bonded to carbon of tetraphenylporphyrin are replaced by fluorine atoms The indicated compound is used as a chelating agent, mixed with a basic organic compound selected from monoethanolamine, diethanolamine, and triethanolamine to prepare an aqueous solution containing a pH regulator that adjusts the pH value to be greater than or equal to pH5.

Description

technical field [0001] The present invention relates to a lithium reagent composition, a lithium ion measurement method and a measurement device using the composition, which are used for quantitative determination of lithium in aqueous solutions such as living body samples or environmental samples. Background technique [0002] Lithium-containing mood stabilizers and antidepressants have been widely used because they are practical and effective, but the serum lithium concentration must be controlled within an appropriate range when taking medication. [0003] As a lithium reagent composition for quantitatively measuring lithium in a liquid, lithium carbonate tablets (oral administration) are usually prescribed together with bipolar disorder (manic-depressive disorder) drugs or antidepressants as a mood stabilizer . If lithium carbonate (Li 2 CO 3 ) is not close to the blood concentration of lithium poisoning, the drug effect cannot be shown. Since the treatment area and t...

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Problems solved by technology

[0010] Everyone knows a thing or two about the existing lithium reagent composition. The combination is a highly toxic substance. The supply of the original drug is unstable and the price is high. The original drug is almost insoluble in water, or once dissolved in water, it will lose its activity and will not Color development, slow color reaction

[0011] The technology disclosed in Patent Document 2, which aims to overcome these problems, has the following problems: the color development method can be realized, but the color development sensitivity is too high, so it is necessary to dilute the test substance, and the specification of the reagent composition is greater than or equal to pH11, so it is easy to be caused by CO in the air 2 Deterioration occurs, the measurement data is unstable, and once the pH is greater than or equal to 11, only thick hydroxide solutions such as sodium hydroxide or potassium hydroxide can be used, and the pH value cannot be maintained at a fixed value. Poison is taboo for users, and it is very troublesome to operate. It does not have versatility in actual storage and requires special containers. In order to make up for these defects, large mechanical devices and special equipment are needed, which lacks versatility.

[0012] Therefore, there is also a problem that it is difficult to apply to on-site monitoring and POCT (Point Of Care Testing)

[0013] However, the reagent composition aimed at quantifying lithium in Patent Document 1 uses a compound completely different from that of the present invention, but it can only be used under the condition of pH 12. As mentioned above, there will be the following problems: once the If the pH is 11, only thick hydroxide solutions such as sodium hydroxide or potassium hydroxide can be used, because these are toxic substances, and it is very troublesome for the user to operate. Moreover, in order to make up for these defects, a large special equipment, thus lack of versatility

[0014] In addition, in the paper of Koyanagi et al. as Non-Patent Document 1, it is pointed out that lithium ions can be separated and detected using F28 tetraphenylporphyrin, but it cannot be obtained without solvent extraction using oily and highly toxic chloroform. Detection and isolation of lithium

[0015] In short, it is impossible to directly quantify lithium in aqueous solution without complicated pretreatment, especially, it is impossible to quickly and quantitatively measure lithium in serum.

As a result, it is difficult to detect lithium in aqueous solution using F28 tetraphenylporphyrin, and it is not easy to quantitatively measure the concentration, which has not been achieved so far.

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