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Application of dehydrolovastatin to preparation of anti-inflammatory bowel disease medicament

A technology of inflammatory bowel disease and lovastatin, which is applied in the field of application of dehydrolovastatin in the preparation of anti-inflammatory bowel disease drugs, and can solve the problem of no ideal drug

Inactive Publication Date: 2016-11-09
CHONGQING MEDICAL & PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Commonly used therapeutic drugs include aminosalicylic acid drugs, glucocorticoids, immunosuppressants and some traditional Chinese medicines, but there is no ideal drug so far. It is of great practical value to develop safe and effective drugs that treat both symptoms and root causes.

Method used

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  • Application of dehydrolovastatin to preparation of anti-inflammatory bowel disease medicament
  • Application of dehydrolovastatin to preparation of anti-inflammatory bowel disease medicament
  • Application of dehydrolovastatin to preparation of anti-inflammatory bowel disease medicament

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] 1. Establishment of experimental anti-inflammatory bowel disease animal model

[0027] 1 Materials and methods

[0028] 1.1 Experimental animals:

[0029] Clean-grade Kunming mice (male), weighing 22-25 grams, were provided by the Experimental Animal Center of Chongqing Medical University.

[0030] 1.2 Main reagents and medicines:

[0031] Dextran sulfate sodium salt (Dextran sulfate sodium salt, DSS, MW: 36000-50000) (US MPBiomedicals)

[0032] Fecal occult blood kit (Nanjing Jiancheng Bioengineering Institute)

[0033] 1.3 Main instruments:

[0034] Electronic balance

[0035] A2000S Electronic Analytical Balance (Sartorius, Germany)

[0036] Sigma-3k cryogenic centrifuge (Sigma, USA)

[0037] -80℃ ultra-low temperature refrigerator (Germany)

[0038] UV-225 UV-Vis Spectrophotometer (Japan)

[0039] BH-2 optical microscope (Olympus, Japan)

[0040] 1.4 Preparation of solution:

[0041] 0.5% sodium carboxymethylcellulose:

[0042] Preparation of 4% DSS aque...

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Abstract

The invention discloses an application of dehydrolovastatin to preparation of an anti-inflammatory bowel disease medicament. The prevention and control actions and the action mechanism of the dehydrolovastatin on a mouse inflammatory bowel disease induced by dextran sulfate sodium are disclosed for the first time through tests of building a mouse acute inflammatory bowel disease model, observing the treatment effect of the dehydrolovastatin on the inflammatory bowel disease, and the like. The dehydrolovastatin significantly inhibits the levels of proinflammatory factors TNF-alpha, IL-6 and IL-17 by inhibiting an NF-kappa B signal path, raises the level of an anti-inflammatory factor IL-10, and plays a role in preventing the mouse inflammatory bowel disease induced by 4-percent DSS (Dextran Sulfate Sodium Salt).

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of dehydrolovastatin in the preparation of anti-inflammatory bowel disease medicines. Background technique [0002] Statins are specific competitive inhibitors of hydroxymethylglutaryl-CoA (3-hydroxy-3-methyl-glutaryl CoA, HMG-CoA) reductase, which can reduce the biosynthesis of cholesterol and have a significant It is the drug of choice in lipid-lowering drugs. And reduce the morbidity and mortality of cardiovascular diseases by improving endothelial function, anti-platelet aggregation, and inhibiting atherosclerosis. Studies in recent years have found that statins still have anti-inflammatory and immunomodulatory effects, and play a certain role in many rheumatism, rheumatoid diseases and autoimmune diseases. [0003] Dehydrolovastatin (dehydrolovastatin, DLVT) is a new member of the statin family obtained in recent years. It is a dehydro derivative of lovastatin and ...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P1/04A61P1/00
CPCA61K31/366
Inventor 邓庆华杨元娟杨治国唐倩夏瀛胡清伟
Owner CHONGQING MEDICAL & PHARMA COLLEGE
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