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Application of cannabidiol in preparing medicines for treating gout

A technology of cannabidiol and drugs, which is applied in the application field of cannabidiol in the preparation of gout drugs, can solve the problems of long-term use, large side effects, and low drug efficacy, and achieves small toxic and side effects, lower serum uric acid levels, The effect of strong anti-gout effect

Inactive Publication Date: 2016-11-09
云南瑞酚生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Poor curative effect and large side effects have become the bottleneck of its clinical application, and it cannot be used for a long time
There are also some Chinese patent medicine preparations commonly used in the market to treat tongfeng, but the efficacy is relatively low.

Method used

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  • Application of cannabidiol in preparing medicines for treating gout
  • Application of cannabidiol in preparing medicines for treating gout
  • Application of cannabidiol in preparing medicines for treating gout

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take cannabis flowers and leaves, after impurity removal, drying, and crushing, CO2 super-extraction, ethanol redissolution after impurity removal, chromatographic separation of the solution and pentane elution, collect the eluate, concentrate under reduced pressure, vacuum Dried and crushed to obtain cannabidiol.

[0043] Get 100 grams of cannabidiol (through 80 mesh sieve), add 60 grams of microcrystalline cellulose, pass through 80 mesh sieve three times, mix well, spray 95% ethanol solution, make soft material, pass through 40 mesh sieve to granulate, 60 ℃ for half an hour, packed in 3# capsules, aluminum-plastic composite packaging, made into capsules.

Embodiment 2

[0045] Take the mixture of cannabis flowers, leaves, and hemp bran, remove impurities, dry, and pulverize, then extract with CO2, and dissolve in ethanol after removing impurities. The solution is separated by chromatography and eluted with pentane, and the eluate is collected. Concentrate under reduced pressure, dry in vacuum, and pulverize to obtain cannabidiol.

[0046] Take cannabidiol powder, add 5-20% of dry starch and 1-5% of magnesium stearate, mix, granulate, dry and compress to form tablets.

Embodiment 3

[0048] Repeat Example 2, with the following differences: get the cannabidiol powder, add sucrose water and a conventional amount of preservatives, stabilizers and other auxiliary materials. Filter, sterilize, and divide into 10mL bottles to make oral liquid.

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Abstract

The invention discloses an application of cannabidiol in preparing medicines for treating gout. The inventor discovers that cannabidiol has a quite strong gout resisting effect for the first time, and the cannabidiol is capable of significantly reducing the serum uric acid level of a mouse with hyperuricemia, avoiding obvious influence on the serum uric acid level of a normal mouse and significantly reducing and inhibiting swelling toes caused by sodium urate; the activity of the cannabidiol is better than that of allopurinol; and the cannabidiol is low in toxic and side effects. The invention also provides a pharmaceutical preparation of the cannabidiol for treating the gout and a corresponding dosage form of the pharmaceutical preparation; and by virtue of a conventional preparation method, the cannabidiol can be prepared into clinically applicable medicines in various dosage forms, and the medicines are convenient to use.

Description

technical field [0001] The present invention relates to the new application of cannabis extract cannabidiol in medicine, in particular to the application of cannabidiol in the preparation of medicine for treating gout. Background technique [0002] Gout is a kind of disease caused by the disorder of purine metabolism in the body. Purine undergoes a series of metabolic changes, and the final product is called uric acid. Uric acid has no physiological function in the human body. Under normal circumstances, 2 / 3 of the uric acid produced in the body is excreted by the kidneys, and 1 / 3 is excreted by the large intestine. Uric acid in the body is constantly produced and excreted, so it maintains a certain concentration in the blood. In the process of purine synthesis and decomposition, various enzymes are involved. Due to the disorder of congenital abnormal metabolism of enzymes, the synthesis of uric acid is increased or the excretion is decreased, which can cause hyperuricemia....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/05A61P19/06
CPCA61K31/05
Inventor 陈天睿胡瀞月
Owner 云南瑞酚生物科技有限公司
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