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A kind of bionic gynecological lotion and preparation method thereof

A gynecological lotion, biomimetic technology, applied in pharmaceutical formulations, medical preparations with non-active ingredients, and medical preparations containing active ingredients, etc. Shortage and other problems, to achieve the effect of highlighting the bactericidal effect, balancing the vaginal flora, and repairing the vaginal acidity

Active Publication Date: 2017-06-16
GUANGDONG COOWAY BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After research, the applicant found that the product had the following disadvantages: ①The biological activity of the antimicrobial peptide was reduced due to the high-salt environment of the artificial body fluid, which eventually led to a significant weakening of its antimicrobial ability; ②Is the composition of the artificial body fluid and human vaginal fluid or There is a big difference, and it is not bionic in the true sense, so its compatibility with the vagina is poor; ③ the product is mainly used to kill harmful bacteria in the vagina to achieve the purpose of treating vaginitis, but it does not affect the vaginal flora. There is no balancing effect, and it cannot repair the damage caused by vaginitis to the vagina, so vaginitis is easy to recur, and people with a history of vaginitis are still high-risk groups of vaginitis; ④ It is because the lotion stays in the vagina for a short time The action time of antimicrobial peptides is too short, so in order to achieve the ideal antibacterial effect, the vagina needs to be repeatedly lavaged every time it is used, and the relationship between multiple times is easy to damage the microenvironment inside the vagina

Method used

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  • A kind of bionic gynecological lotion and preparation method thereof
  • A kind of bionic gynecological lotion and preparation method thereof
  • A kind of bionic gynecological lotion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1, a kind of bionic gynecological lotion

[0033] The present embodiment 1 bionic gynecological lotion is composed of the following components: housefly antimicrobial peptide 0.1g, xylooligosaccharide 6.0g, xanthan gum 0.1g, NaCl 8.0g, KCl 0.45g, CaCl 2 0.15g, NaHCO 3 0.4g, MgCl 2 ·6H 2 O 0.015g, MgSO 4 ·7H 2 O 0.05g, KH 2 PO 4 0.06g, Na 2 HPO 4 12H 2 O 0.06g, glucose 1.0g, urea 1.5g, Gram-positive bacterial cell debris 0.002g, with deionized water to 1L, wherein, the growth factor is composed of recombinant human epidermal growth factor and recombinant human basic fibroblast The cell growth factor is composed at a weight ratio of 1:1, and the gram-positive bacterial cell fragments are composed of bifidobacterium cell fragments and lactobacillus cell fragments at a weight ratio of 1:1.

[0034] Preparation:

[0035] A) NaCl, KCl, CaCl 2 , NaHCO 3 , MgCl 2 ·6H 2 O, MgSO 4 ·7H 2 O. KH 2 PO 4 、Na 2 HPO 4 12H 2 O, urea, Gram-positive bact...

Embodiment 2

[0038] Embodiment 2, a kind of bionic gynecological lotion

[0039] The bionic gynecological lotion of Example 2 is composed of the following components: 0.1 g of housefly antimicrobial peptide, 6.0 g of xylooligosaccharide, 0.1 g of xanthan gum, 8.0 g of NaCl, 0.45 g of KCl, and 0.45 g of CaCl 2 0.15g, NaHCO 3 0.4g, MgCl 2 ·6H 2 O 0.015g, MgSO 4 ·7H 2 O 0.05g, KH 2 PO 4 0.06g, Na 2 HPO 4 12H 2 O 0.06g, glucose 1.0g, urea 1.5g, Gram-positive bacterial cell debris 0.002g, water-soluble VE0.4g, natural moisturizing factor 0.2g and free amino acid 0.4g, dilute to 1L with deionized water, wherein, The growth factor is composed of recombinant human epidermal growth factor and recombinant human basic fibroblast growth factor at a weight ratio of 1:1, and the free amino acid is composed of glycine, alanine, aspartic acid and serine at a ratio of 1:1 : 1:1 weight ratio, the Gram-positive bacterial cell fragments are composed of Bifidobacterium cell fragments and Lactobaci...

Embodiment 3

[0041] Embodiment 3, a kind of bionic gynecological lotion

[0042] The bionic gynecological lotion of Example 3 is composed of the following components: 0.2 g of housefly antimicrobial peptide, 5.0 g of xylooligosaccharide, 0.1 g of xanthan gum, 8.0 g of NaCl, 0.45 g of KCl, and 0.45 g of CaCl 2 0.15g, NaHCO 3 0.4g, MgCl 2 ·6H 2 O 0.015g, MgSO 4 ·7H 2 O 0.05g, KH 2 PO 4 0.06g, Na 2 HPO 4 12H 2 O 0.06g, glucose 1.0g, urea 1.5g, Gram-positive bacterial cell debris 0.001g, water-soluble VE 0.4g, natural moisturizing factor 0.2g and free amino acid 0.4g, dilute to 1L with deionized water, wherein, The growth factor is composed of recombinant human epidermal growth factor and recombinant human basic fibroblast growth factor at a weight ratio of 1:1, and the free amino acid is composed of glycine, alanine, aspartic acid and serine at a ratio of 1:1 : 1:1 weight ratio, the Gram-positive bacterial cell fragments are composed of Bifidobacterium cell fragments and Lactobac...

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PUM

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Abstract

Disclosed are a bionic gynecological lotion and a preparation method therefor. The lotion comprises a Musca domestica antibacterial peptide, a xylooligosaccharide, a xanthan gum and an artificial simulated vaginal secretion with a pH of 3.3-4.8, wherein the contents of the Musca domestica antibacterial peptide, the xylooligosaccharide and the xanthan gum in the artificial simulated vaginal secretion are 0.1-10.0 g / L, 5-10.0 g / L and 0.05-0.15 g / L.

Description

technical field [0001] The invention belongs to the field of personal cleaning products, and in particular relates to a bionic gynecological lotion and a preparation method thereof. Background technique [0002] Vaginitis is the inflammation of vaginal mucosa and submucosal connective tissue, and is the most common disease in gynecology. Due to the anatomical and biochemical characteristics of normal healthy women, the vagina has a natural defense function against the invasion of pathogens. When the natural defense function of the vagina is destroyed, the pathogens will take the opportunity to invade and cause vaginal inflammation. According to statistics, more than 80% of married women of childbearing age in my country are troubled by this disease, whether mild or severe. [0003] Vaginitis is mainly caused by the imbalance of flora in the vagina, that is, the imbalance of the micro-ecological balance (flora) normally parasitic in the vagina, the beneficial bacteria such a...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61K47/61A61P15/02A61P31/04A61K31/702A61K31/715A61K35/745A61K35/747
CPCA61K9/08A61K31/702A61K35/74A61K38/17A61K47/36
Inventor 陈松彬易萍张爱萍倪彦艳吴纯玲
Owner GUANGDONG COOWAY BIOTECH CO LTD
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