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Periplaneta woody composition and its application

A composition, the technology of Muxiang, applied in the treatment of peptic ulcer, the field of the composition of Muxiang Periplaneta, can solve the problem of no research report on the influence of peptic ulcer, and achieve good and significant medicinal effects Effect

Active Publication Date: 2019-11-08
SOUTHWEST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It can be seen that, in the treatment of gastrointestinal diseases, both woody and American cockroaches have certain positive effects, but there is no research report on the impact of the two combined on peptic ulcer

Method used

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  • Periplaneta woody composition and its application
  • Periplaneta woody composition and its application
  • Periplaneta woody composition and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation method of embodiment 1 extract

[0020] Woody extract: ground woody powder into coarse powder, weighed 100g and put it into a Soxhlet extractor, added 1L of 95% ethanol, refluxed extraction for 2 hours, collected the extract, filtered, recovered ethanol under reduced pressure, and obtained viscous woody ethanol The extract was 7.23g, and it mainly contained coyneolactone and dehydrocoylolide through HPLC analysis.

[0021] Periplaneta americana extract: Crush Periplaneta americana into a coarse powder, weigh 100g and put it into a Soxhlet extractor, add 1L of petroleum ether at 60-90°C, reflux for 1 hour, and perform degreasing treatment. After collecting the petroleum ether extract, the remaining The solid component, that is, the defatted Periplaneta americana powder, was continuously extracted with 1.5 L of 95% ethanol under reflux for 1.5 h, the ethanol extract was collected, filtered, and the ethanol was recovered under reduced pressure to obtain the...

Embodiment 2

[0022] Embodiment 2 Woody Periplaneta americana composition

[0023] Woody Periplaneta americana composition, specific formula is as follows:

[0024] Recipe: 1g of woody extract, 1g of Periplaneta americana extract.

[0025] According to Example 1, the extracts of Periplaneta americana and Periplaneta americana were prepared, and the prepared extracts were mixed uniformly according to the above formula ratio to obtain a composition of Periplaneta americana.

Embodiment 3

[0026] Example 3 Application of Periplaneta americana Composition in Treating Ethanol Gastric Injury

[0027] Take 24 rats, 12 males and 12 males, and divide them into 4 groups at random, 6 rats in each group, namely the model group, the extract group of Periplaneta americana, the extract group of Periplaneta americana and the mixed group of Periplaneta americana. The model group was given an equal volume of 0.5% CMC-Na, the Muxiang group was given 1 g / kg of the extract of the present invention, the Periplaneta americana group was given 1 g / kg of the Periplaneta americana extract, and the Periplaneta americana mixture group was given 1 g / kg. Administer the 1:1 mixture of the extracts of Cassia sinensis and Periplaneta americana, the extracts are all suspended in 0.5% CMC-Na solution, and administered once a day by intragastric administration for 7 consecutive days. One hour after the last administration, the rats in each group were intragastrically administered with 1 mL of ab...

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Abstract

The invention discloses a radix aucklandiae and periplaneta composition and application thereof. The composition is prepared from radix aucklandiae extract and periplaneta extract. The preparation method of the radix aucklandiae extract includes the following steps that radix aucklandiae is subjected to reflux extraction for 1-3 h in an ethanol solvent to obtain radix aucklandiae extraction liquor, the radix aucklandiae extraction liquor is filtered to obtain radix aucklandiae filter liquor, the radix aucklandiae filter liquor is subjected to pressure reduction to recycle ethanol, and the thick radix aucklandiae extract is obtained. The preparation method of the periplaneta extract includes the following steps that periplaneta is degreased and then subjected to reflux extraction for 1-3 h in an ethanol solvent to obtain periplaneta extraction liquor, the periplaneta extraction liquor is filtered to obtain periplaneta filter liquor, the periplaneta filter liquor is subjected to pressure reduction to recycle ethanol, and the periplaneta extract is obtained. The composition has a very significant medicinal effect when used for treating the peptic gastric ulcer; especially for stomach injury caused by ethanol or aspirin, the medicinal effect of the composition is better than that of single radix aucklandiae extract or periplaneta extract.

Description

technical field [0001] The invention belongs to the field of pharmaceutical formulations, in particular to a composition of Periplaneta xanthus and its application in treating peptic ulcer. Background technique [0002] Gastric ulcer and duodenal ulcer are collectively called peptic ulcer, which is one of the most common chronic gastrointestinal dysfunction diseases worldwide, with an incidence rate as high as 10%. Helicobacter pylori infection, damage factors such as gastric acid and pepsin, and the reduction of mucosal self-protection ability are currently recognized as the main pathogenesis. The clinical manifestations of peptic ulcer are epigastric pain, bleeding, perforation and other complications. Drug treatment is still the main treatment, but the treatment is difficult. At present, the treatment of peptic ulcer is still based on drug therapy, including chemical drugs and traditional Chinese medicine. Chemical drugs mainly include aluminum sulfate, cimetidine, omep...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/285A61P1/04A61K35/64
CPCA61K35/63A61K36/285A61K2236/33A61K2300/00
Inventor 袁吕江任巧
Owner SOUTHWEST UNIV
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