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Amphiphilic silane-coated water-soluble composite nano-material and application thereof

A technology of water-soluble composite and nanomaterials, applied in analytical materials, luminescent materials, material excitation analysis, etc., can solve the problems of difficult biological application, complicated operation steps, large size of water-soluble nanoparticles, etc.

Inactive Publication Date: 2016-09-21
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, some nanomaterials with uniform size are often synthesized under oil phase conditions, and there will be many lipophilic groups on the surface of these materials, making it difficult for the entire nanomaterial to exist stably in water, which greatly limits their Applications in the biological field
Some traditional coating methods, such as silica coating, have cumbersome operation steps and the formation of water-soluble nanoparticles with large size
However, larger-sized nanomaterials are not easily endocytized by cells, which poses certain difficulties for their biological applications.

Method used

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  • Amphiphilic silane-coated water-soluble composite nano-material and application thereof
  • Amphiphilic silane-coated water-soluble composite nano-material and application thereof
  • Amphiphilic silane-coated water-soluble composite nano-material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] First, ferric oxide nanoparticles were synthesized according to the co-precipitation method, and the surface was coated with oleic acid in order to increase its stability (Wang, J., et al.Remote manipulation ofmicronomachines containing magnetic nanoparticles. Optics Letters 34,581- 583 (2009)).

[0025] The prepared oily iron ferric oxide nanoparticles and n-octyltrimethoxysilane (purchased from sigma company) were respectively configured into 5 mg / mL tetrahydrofuran solutions, and then 1 mL of the above two solutions were mixed.

[0026] Add dropwise 0.02 mL of tetrahydrofuran solution of coumarin 6 (purchased from sigma company) with a concentration of 1 mg / mL and 0.2 mL of chlorin e6 (purchased from sigma company) with a concentration of 1 mg / mL in the above mixed solution THF solution.

[0027] The above mixed solution was sonicated for 10 minutes to make it evenly mixed, and then it was injected into 10 mL of ammonia solution (pH value was 9) to carry out hydroly...

Embodiment 2

[0036] Repeat Example 1, the difference is that this time the loaded functional oily molecule is platinum(II) meso-tetrakis(pentafluorobenzene)porphine (purchased from sigma company) with oxygen sensing function. It was made into 1mg / mL tetrahydrofuran solution, and 0.1mL was added to the mixture of oily iron ferric oxide nanoparticles and amphiphilic silane under the same conditions as in Example 1, and the rest of the steps were the same as in Example 1. The resulting product concentration was 0.835 mg / mL.

[0037] see Image 6 , when using 392nm excitation light to excite the magnetic composite nanomaterial, because it contains platinum (II) meso-tetrakis (pentafluorobenzene) porphine, it will emit red light, and its peak position is at 650nm. And the intensity value of the emitted light changes with the change of the surrounding oxygen content. When using a gas mixer to configure mixed gases with different oxygen contents (volume fractions of oxygen are 0, 20, 40, 60, 80...

Embodiment 3

[0040] Repeat embodiment 1, change the oily copper sulfide nanoparticles into the oily copper sulfide nanoparticles in embodiment 1, the synthesis steps of copper sulfide nanoparticles here are synthesized with reference to this document (Liu, L., et al. Controllable Transformation from Rhombohedral Cu1.8S Nanocrystals to Hexagonal CuS Clusters: Phase-and Composition-Dependent Plasmonic Properties. Chemistry of Materials 25, 4828-4834(2013)). Here, only the water-soluble modification of oily copper sulfide nanoparticles was completed, and functional oily molecules were not added to the interlayer of silane and copper sulfide nanoparticles. The resulting product concentration was 0.833 mg / mL.

[0041] see Figure 8 , is the transmission electron microscope image of the water-soluble copper sulfide composite nanomaterial coated with amphiphilic silane after synthesis, and its size is about 10nm.

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Abstract

The invention provides an amphiphilic silane-coated water-soluble composite nano-material and application of the same to oxygen sensing, fluorescence labeling, photodynamic therapy and the like, belonging to the technical field of biomaterials. According to the invention, an oily nanoparticle is used as a core; amphiphilic silane is used for coating so as to allow the oily nanoparticle to become water-soluble; and the properties of the core are retained, e.g., superparamagnetism of a magnetic nano-material. As the oily nanoparticle is turned water-soluble, different functional oily molecules (such as one or more than one selected from a group consisting of platinum (II) meso-tetra(pentafluorophenyl)porphine with an oxygen sensing function, coumarin 6 with a fluorescence labeling function, chlorine e6 with a photodynamic therapy function and the like) are loaded into an interlayer formed by silane and the oily nanoparticle, so multiple functions of the composite nano-material are achieved. A mass ratio of the functional oily molecules to the oily nanoparticle is properly no more than 0.3: 1.

Description

technical field [0001] The invention belongs to the technical field of biomaterials, and in particular relates to a water-soluble composite nanomaterial coated with amphiphilic silane and its application in oxygen sensing, fluorescent labeling, photodynamic therapy and the like. Background technique [0002] Multifunctional composite nanomaterials have received extensive attention. Due to their small size advantages and multifunctional characteristics, the development of new composite nanomaterials will provide great help for cancer diagnosis and treatment. In order to apply composite nanomaterials in vivo, it is first necessary to ensure their good water solubility and biocompatibility, so as to minimize the impact of materials on cell activity. And try to make the material have a variety of different functions, such as fluorescent labeling, drug loading, sensing, photothermal therapy and photodynamic therapy. [0003] However, some nanomaterials with uniform size are ofte...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/02C09K11/06A61K41/00A61K49/10A61K49/18A61K49/00G01N21/64C12Q1/02
CPCC09K11/025A61K41/0066A61K41/0071A61K49/0052A61K49/10A61K49/1818C09K11/06C09K2211/1074C09K2211/1088C09K2211/185G01N21/6402
Inventor 董彪徐诗函许红威宋宏伟白雪徐琳孙雪珂
Owner JILIN UNIV
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