Application of nf-κb p65/HMGCS2 regulatory pathway in preparation of drugs regulating ketone body synthesis

Abstract

The invention discloses the application of the NF-κB p65 / HMGCS2 regulatory pathway as a drug target in the preparation of medicines and health products that regulate ketone body synthesis; NF-κB p65 is combined with the HMGCS2 promoter to regulate the expression of the enzyme from the transcriptional level, HMGCS2 affects the synthesis level of ketone bodies; it can activate NF‑κB p65, regulate the expression of HMGCS2 from the transcriptional level, and then regulate the metabolism of ketone bodies, indirectly strengthen the synthesis of ketone bodies, improve the energy metabolism of nerve cells, etc. The role of degenerative disease.

Description

technical field [0001] The invention belongs to the technical field of drugs for regulating ketone body synthesis, and relates to the application of NF-κB p65 / HMGCS2 regulation pathway in the preparation of drugs for regulating ketone body synthesis. Background technique [0002] Ketone body is a general term for acetoacetate, β-hydroxybutyrate (β-hydroxybutyrate, βOHB) and acetone in mammals. Ketogenic, or the synthesis of ketone bodies, is a branch of mammalian metabolism. When the level of glucose metabolism decreases, the level of ketone bodies produced by the liver increases. The synthesis of ketone bodies mainly occurs in the liver, and astrocytes in the brain can also produce a small amount of ketone bodies. In the absence of glucose, ketone bodies are used as energy substrates for extrahepatic tissues. [0003] In recent years, studies have found that ketone bodies, as a substitute for glucose energy supply, appear in the early stage of AD and decline as the disea...

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