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Preparation method of fructus psoraleae extract and fructus psoraleae extract

A technology of psoralen extract and psoralen, which is applied in the preparation of psoralen extract and the field of psoralen extract, can solve the problems of unfavorable preparation molding and low transfer rate of water reflux extraction

Inactive Publication Date: 2016-09-07
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However, the previous research results show that the direct water reflux extraction of Danshen has a solid content of about 50%, which is not conducive to the formulation of the preparation. Tanshinone components are fat-soluble components, and the transfer rate of water reflux extraction is low.

Method used

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  • Preparation method of fructus psoraleae extract and fructus psoraleae extract
  • Preparation method of fructus psoraleae extract and fructus psoraleae extract
  • Preparation method of fructus psoraleae extract and fructus psoraleae extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0157] Example 1: Effects of Different Extraction Methods on Contents of Each Index Component of Psoraleae Extract

[0158] 1. Sample preparation:

[0159] 1. Heat reflux extraction method: 100 g of psoralen medicinal material, 70% ethanol heat reflux twice (10 times the amount, 8 times the amount), each time for 1.5 hours, combine the extracts, concentrate under reduced pressure to obtain a thick extract.

[0160] 2. Cold soaking method: 500g of psoralen medicinal material, 70% ethanol cold soaking extraction 3 times (5 times the amount, 4 times the amount, 4 times the amount), 36h each time, stirring constantly during the cold soaking, combining the extracts, 1: 1 Concentrate under reduced pressure to about 500ml, after standing for stratification, pour off the upper layer (remove the water-soluble components, and recover under reduced pressure to obtain dry paste powder), to obtain the lower layer thick extract.

[0161] 3. Percolation method: 500g of psoraleae medicinal...

Embodiment 2

[0182] Embodiment 2: The condition and parameter comparison of extracting psoraleae by percolation

[0183] 1. The influence of different extraction solvents on the extraction rate of two elements in psoralen

[0184] (1) Purpose of the experiment

[0185] The influence of different extraction solvents (50%, 70%, 95% ethanol) on the extraction rate of two elements (psoralen and isopsoralen, the same below) was investigated.

[0186] (2) Experimental method

[0187] The filling amount of psoralen (500g) reaches 2 / 3 of the percolation cylinder (diameter-to-height ratio 1:3, 10cm x 30cm), the soaking time is 12h, the flow rate is 8mL / min / Kg, and the percolation liquid: medicinal material (v : m) 1:1 fractions were collected, each fraction was 500ml, a total of 15 fractions were collected, the percolation solution was combined, concentrated under reduced pressure at 50°C to 750ml, and left to separate for stratification to obtain the lower thick extract.

[0188] (3) Experime...

Embodiment 3

[0232] Example 3: Comparison of extract samples of Eucommia miltiorrhiza anemarrhena and formula granules

[0233] 1. Preparation of Eucommia miltiorrhiza Anemarrhena extract:

[0234] The Danshen decoction pieces were soaked in 2 times the amount of 95% ethanol for 24 hours, and extracted by percolation with 95% ethanol at a flow rate of about 16ml / kg.min. Ethanol is recovered from the percolation solution under reduced pressure, concentrated to a relative density of about 1.15 (50° C.), and then vacuum-dried to obtain the fat-soluble extract of Salvia miltiorrhiza (miltiorrhiza miltiorrhiza) for future use. The prescribed amount of Eucommia decoction pieces, percolated Danshen herbal dregs and Anemarrhena decoction pieces were combined, decocted twice with water, 8 times the amount of water each time, decocted for 3 hours each time, combined the water extracts twice, concentrated under reduced pressure to relative The density is about 1.15 (50°C), add 3 times the amount o...

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Abstract

The invention belongs to the field of traditional Chinese medicines and relates to a preparation method of a fructus psoraleae extract and the fructus psoraleae extract. The preparation method specifically comprises the following steps 1)-5) or 1)-6): 1) soaking fructus psoraleae for 1-36 hours by using 1-20 times of 50-95 percent of ethanol; 2) extracting by using 50-95 percent of ethanol percolate, wherein the flow rate is 4-16 mL / min / Kg; 3) collecting a percolate which is 5-20 times of the feeding amount of the fructus psoraleae in volume; 4) concentrating the percolate; 5) leaving to stand for layering, decanting an supernatant and taking a lower layer to obtain a thick fructus psoraleae extract; 6) diluting the thick fructus psoraleae extract by using a proper amount of ethanol, adding into auxiliary powder while stirring, wherein the proportion of the fructus psoraleae crude drug quantity to the quantity of the auxiliary powder is (10:2.5)-(10:3); uniformly stirring, drying, crushing and sieving to obtain the fructus psoraleae extract. The fructus psoraleae extract provided by the invention is basically non-toxic to the liver and can effectively prevent and treat diseases related to in-vivo estrogen level disorder or improve symptoms.

Description

[0001] The present invention is a divisional application of the application number 201310524167.3, the application date is October 30, 2013, and the invention title is "a pharmaceutical composition for regulating estrogen level, its preparation method and application". technical field [0002] The invention belongs to the field of traditional Chinese medicines, and relates to a preparation method of psoralen extract and the psoralen extract. Background technique [0003] Psoraleae is the dry and mature fruit of Psoralea corylifolia L., a leguminous plant. It has the effects of warming the kidney and helping the yang, invigorating Qi and relieving asthma, warming the spleen and stopping diarrhea. , Diarrhea before dawn, cough due to deficiency and cold; external use for vitiligo. [0004] Psoraleae mainly contains coumarin, flavonoids, monoterpene phenols and other components. Modern pharmacological studies have shown that psoralen has the effects of dilating blood vessels, i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/487A61P5/30A61P15/12A61P9/10A61P9/00A61P9/12A61P19/10
CPCA61K36/487A61K2236/333
Inventor 高秀梅王跃飞刘二伟王亚静樊官伟王怡皮佳鑫张伯礼
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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