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Pharmaceutical composition for adjusting estrogen level as well as preparation method and application thereof

A composition and drug technology, which is applied in the field of pharmaceutical compositions for regulating estrogen levels, can solve the problems of unfavorable preparation molding, low transfer rate of water reflux extraction, etc.

Inactive Publication Date: 2014-02-05
TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] However, the previous research results show that the direct water reflux extraction of Salvia miltiorrhiza has about 50% solid content, which is not conducive to the preparation of formulations. Tanshinone components are fat-soluble components, and the transfer rate of water reflux extraction is low.

Method used

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  • Pharmaceutical composition for adjusting estrogen level as well as preparation method and application thereof
  • Pharmaceutical composition for adjusting estrogen level as well as preparation method and application thereof
  • Pharmaceutical composition for adjusting estrogen level as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0155] Example 1: Effects of Different Extraction Methods on Contents of Each Index Component of Psoraleae Extract

[0156] 1. Sample preparation:

[0157] 1. Heat reflux extraction method: heat 100g of psoraleae medicinal material, heat and reflux twice with 70% ethanol (10 times the amount, 8 times the amount), each time for 1.5h, combine the extracts, concentrate under reduced pressure to obtain a thick extract.

[0158] 2. Cold-soaking method: 500g of psoraleae medicinal material, cold-soaked and extracted with 70% ethanol for 3 times (5 times, 4 times, 4 times), each time 36h, stirring continuously during the cold immersion, and combining the extracts, 1: 1 Concentrate under reduced pressure to about 500ml, after standing for stratification, pour off the upper layer (remove the water-soluble components, and recover under reduced pressure to obtain dry paste powder), to obtain the lower layer thick extract.

[0159] 3. Percolation method: 500g of psoralen medicinal mate...

Embodiment 2

[0182] Embodiment 2: The condition and parameter comparison of extracting psoraleae by percolation

[0183] 1. The influence of different extraction solvents on the extraction rate of two elements in psoralen

[0184] (1) Purpose of the experiment

[0185] The influence of different extraction solvents (50%, 70%, 95% ethanol) on the extraction rate of two elements (psoralen and isopsoralen, the same below) was investigated.

[0186] (2) Experimental method

[0187] The filling amount of psoralen (500g) reaches 2 / 3 of the percolation cylinder (diameter-to-height ratio 1:3, 10cm x30cm), the soaking time is 12 hours, the flow rate is 8mL / min / Kg, and the percolation liquid: medicinal material (v: m) Collect fractions at 1:1 ratio, each fraction is 500ml, a total of 15 fractions are collected, the percolation solution is combined, concentrated under reduced pressure at 50°C to 750ml, allowed to stand and separated to obtain the thick extract of the lower layer.

[0188] (3) Ex...

Embodiment 3

[0233] Example 3: Comparison of extract samples of Eucommia miltiorrhiza anemarrhena and formula granules

[0234] 1. Preparation of Eucommia miltiorrhiza Anemarrhena extract:

[0235] The Danshen decoction pieces were soaked in 2 times the amount of 95% ethanol for 24 hours, and extracted by percolation with 95% ethanol at a flow rate of about 16ml / kg.min. Ethanol is recovered from the percolation liquid under reduced pressure, concentrated to a relative density of about 1.15 (50°C), and then vacuum-dried to obtain the fat-soluble extract of Salvia miltiorrhiza miltiorrhiza (miltiorrhiza miltiorrhiza) for future use. The prescribed amount of Eucommia decoction pieces, percolated Danshen herbal dregs and Anemarrhena decoction pieces were combined, decocted twice with water, 8 times the amount of water each time, decocted for 3 hours each time, combined the water extracts twice, concentrated under reduced pressure to relative The density is about 1.15 (50°C), add 3 times the...

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Abstract

The invention belongs to the field of traditional Chinese medicines, relates to a pharmaceutical composition for adjusting estrogen level as well as a preparation method and application thereof, and in particular relates to a method for preparing the pharmaceutical composition. The method comprises the steps of preparing a fructus psoraleae extract and preparing a eucommia ulmoides extract, a radix salviae miltiorrhizae extract and a rhizoma anemarrhenae extract. The invention also relates to the pharmaceutical composition prepared by the method. The pharmaceutical composition comprising the fructus psoraleae extract, the eucommia ulmoides extract, the radix salviae miltiorrhizae extract and the rhizoma anemarrhenae extract is basically free of toxicity for liver, and can effectively prevent and treat diseases related to the imbalance of in-vivo estrogen level or reduce the symptom.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and relates to a pharmaceutical composition for regulating estrogen level, its preparation method and application. Background technique [0002] Psoraleae is the dry and mature fruit of Psoralea corylifolia L., a leguminous plant. It has the effects of warming the kidney and helping the yang, invigorating Qi and relieving asthma, warming the spleen and stopping diarrhea. , Diarrhea before dawn, cough due to deficiency and cold; external use for vitiligo. [0003] Psoraleae mainly contains coumarin, flavonoids, monoterpene phenols and other components. Modern pharmacological studies have shown that psoralen has the effects of dilating blood vessels, increasing myocardial contractility, antibacterial, anti-tumor, enhancing immunity, and estrogen-like effects. The Pharmacopoeia of the People's Republic of China 2010 Edition Part One stipulates that psoralen and isopsoralen are used as th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8964A61P5/30A61P15/12A61P9/10A61P9/14A61P9/12A61P19/10
CPCA61K36/487A61K2236/333
Inventor 高秀梅王跃飞刘二伟王亚静樊官伟王怡皮佳鑫张伯礼
Owner TIANJIN UNIV OF TRADITIONAL CHINESE MEDICINE
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