Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of omeprazole in preparing medicine for treating autoimmune disease

An autoimmune and omeprazole technology, which is applied in the field of medicine and can solve problems such as the limited use of omeprazole

Inactive Publication Date: 2016-09-07
徐祗栋
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The present invention aims at the technical defects of the prior art, and provides the application of omeprazole for the preparation of autoimmune disease therapeutic drugs, so as to solve the technical problem that the scope of use of omeprazole is relatively limited in the prior art

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of omeprazole in preparing medicine for treating autoimmune disease
  • Application of omeprazole in preparing medicine for treating autoimmune disease

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] Specific embodiments of the present invention will be described in detail below. In order to avoid too many unnecessary details, well-known structures or functions will not be described in detail in the following embodiments.

[0021] Approximate language used in the following examples is for quantitative representations, indicating that certain variations in quantities are permissible without altering essential function. Accordingly, values ​​modified by language such as "about", "approximately" and the like are not limited to the exact value itself. In some embodiments, "about" means that the corrected value is allowed to vary within the range of plus or minus ten percent (10%), for example, "about 100" means any value between 90 and 110. Furthermore, in the expression "about the first value to the second value", both values ​​of the first value and the second value are corrected approximately at the same time. In some cases, the language of approximation may relate...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides an application of omeprazole in preparing a medicine for treating autoimmune disease. Based upon experiments, the omeprazole, through oral administration, can take a concrete effect on relieving the autoimmune disease, in particular inflammatory injury caused by the autoimmune disease. Further experiments show that the omeprazole can down-regulate mRNA levels of four proinflammatory cytokines, namely [gamma] interferon in a spleen with EAN (experimental allergic neuritis), tumor necrosis factor [alpha], interleukin 6 and interleukin 17, and meanwhile, the omeprazole can up-regulate mRNA levels of two proinflammatory cytokines, namely interleukin 4 and interleukin 10. Moreover, cytokine expression profile of ELISA detection also shows a similar trend in a spleen mononuclear cell culture supernatant. On the basis of the pharmacological properties, the omeprazole, which can take the effect on treating the autoimmune disease, is applicable to preparation of the medicine for treating the autoimmune disease.

Description

technical field [0001] The invention relates to the technical field of medicine, and further relates to the new medical application of substances, in particular to the application of omeprazole in the preparation of medicines for autoimmune diseases. Background technique [0002] Autoimmune diseases refer to diseases caused by the body's immune response to self-antigens, resulting in damage to its own tissues. Since the cause is the autoimmune system, the treatment of these conditions focuses on the modulation of the immune system, usually over a long period of time. In the prior art, depending on the location of autoimmune disease lesions, there are differences in the focus of treatment methods. Generally speaking, the treatment of autoimmune diseases currently mainly relies on immunosuppressants, the most commonly used are adrenocortical hormone preparations, such as : Prednisone, hydrocortisone, dexamethasone, etc., which are often referred to as "hormones" for short. I...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K31/4439A61P29/00A61P25/00A61P37/02
CPCA61K31/4439
Inventor 徐祗栋
Owner 徐祗栋
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com