Preparation method of ophthalmological viscoelastic agent with selective anterior capsule staining function

Abstract

The invention relates to the technical field of medical biomaterials. Cataract treatment becomes the ophthalmic clinical attention focus and a main treatment means comprises combination of lens extraction and artificial lens implantation. At present, the main clinical problem comprises intraocular pressure increasing caused by a low anterior lens capsule tear success rate and residual of a viscoelastic agent in the eye. The invention provides the preparation method of the ophthalmological viscoelastic agent with the selective anterior capsule staining function. The preparation method comprises adding a Trypan blue staining agent with a concentration of 0.002-0.6% into a material and carrying out high temperature and high pressure sterilization. The use of the staining agent does not change viscoelastic agent gel properties and an in-vitro release rate in 60min is about 15% so that the staining agent can be continuously and slowly released to an operation part so that selective staining is realized and damage to tissue cells is prevented. Based on the characteristic, the viscoelastic agent can be effectively removed through staining agent instruction after an operation.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to a method for preparing an ophthalmic viscoelastic agent with selective anterior capsule dyeing function. Selective dyeing of the cyst can improve the success rate of the operation; at the same time, it can improve the removal rate of the viscoelastic agent after the operation and reduce the occurrence of postoperative complications. Background technique [0002] With the development of medical care for the elderly, the life expectancy of human beings is generally extended, and the incidence of cataract has a tendency to increase year by year. It is estimated that by 2020, the number of accumulated cataracts in my country will reach 5 million. In view of the widespread social nature of cataract diseases and the improvement of modern people's requirements for quality of life, cataract treatment has become the focus of ophthalmology clinical attention, and has develope...

AI Technical Summary

Problems solved by technology

[0007] The most common stains on the market today are trypan blue and indocyanine green. Although the above stains still have some disadvantages, indocyanine green can be toxic to corneal endothelial cells at low concentrations. Although trypan Blue has little cytotoxicity, but when the capsule is stained alone, the vitreous body and the implanted intraocular lens will also be stained at the same time, resulting in adverse consequences such as vision loss and monocular diplopia. In the retrospective comparison of Gouws et al. It was found in the study that in cases of cataract phacoemulsification with trypan blue staining, the incidence of postoperative cystoid macular edema was higher than that of conventional surgery; On the contrary, it will flow unrestrictedly and penetrate backwards, such as vitreous body, etc., causing staining of other tissues, and then producing a series of adverse consequences

Therefore, it is the key to solve the above problems to achieve selective dyeing by means of the viscoelasticity and cohesion of the viscoelastic after mixing the dyeing agent with the viscoelastic agent, and no similar products have appeared so far.

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