Patterned substrate for constructing in-vitro tumour model

Abstract

The invention discloses a patterned substrate for constructing an in-vitro tumour model. The patterned substrate comprises a substrate layer and a patterned structure which is arranged on the substrate layer; the patterned structure forms the in-vitro tumour model on the substrate layer after being subjected to pulling treatment. The in-vitro tumour model constructed on the substrate layer can be used for simulating an in-vivo tumour tissue, so that the cell biological behaviours of tumour cells are researched, and the interactions among cells are observed; the in-vitro tumour model can also be used for screening medicaments and observing the effects of an anti-tumour medicament on the tumour cells in the in-vitro tumour model. According to the patterned substrate for constructing the in-vitro tumour model, the in-vitro tumour model which is prepared by a simple method has the characteristics of simple operation, portability, individuation and the like; an important research platform is provided for precision medicine and translational medicine research.

Description

technical field [0001] The invention belongs to the field of on-chip laboratory processing and preparation and biomedicine technology, and in particular relates to a patterned substrate for constructing an in vitro tumor model. Background technique [0002] With the continuous cross-infiltration of medicine, physics, chemistry, biology and other disciplines, new research fields such as translational medicine and precision medicine have emerged. Modern medical research highlights the rapid transformation of basic research results into clinical practice, as well as the characteristics of personalization and portability. In the traditional two-dimensional cell culture method based on Petri dish, the culture conditions are very different from the microenvironment in vivo, and the cultured somatic cells cannot perform normal tissue-level functions, and their lifespan is relatively short. In addition to the high cost, long period, and differences between species and errors in pre...

AI Technical Summary

Problems solved by technology

The traditional two-dimensional cell culture method based on Petri dish, its culture conditions are very different from the microenvironment in the body, the cultured somatic cells cannot perform normal tissue level functions, and the life span is relatively short

In addition to the high cost, long cycle, inter-species differences, and errors in predicting human diseases, animal experiments also have ethical risks.

Images