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Method using ultrasonically-assisted supercritical extraction rectification to purify cynarin in globe artichoke

An ultrasonic-assisted extraction and rectification technology, which is applied in the separation/purification of carboxylic acid esters, organic chemistry, pharmaceutical formulations, etc., can solve the problems of low cynicin quality, high temperature of the extraction system, and cynicin destruction. Achieve the effect of lowering the temperature, increasing the extraction capacity and increasing the content

Inactive Publication Date: 2016-08-24
HUNAN UNIV OF ARTS & SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Current supercritical CO 2 The fluid extraction method has the following problems in the extraction and rectification of artichoke leaves: 1. The extraction capacity is low and the efficiency is not high; 2. The temperature of the extraction system is high, and the heat-sensitive cymarin will be destroyed; 3. , The quality of the extracted and purified artichoke is not high

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] (1) After fresh artichoke leaves are harvested, diseased leaves and yellow leaves are removed, rinsed to remove soil and other impurities, dried at low temperature, put into a crushing equipment, crushed, and passed through a 50-mesh sieve to obtain coarse artichoke leaf powder;

[0015] (2) Soak the prepared artichoke leaf coarse powder with 75% ethanol solution, the ratio of solid to liquid is 1:1, and soak for 3 hours at room temperature;

[0016] (3) Put the soaked artichoke leaf meal into the ultrasonic extraction kettle for CO 2 Supercritical extraction; the temperature of the extraction kettle is 35°C, the pressure of the extraction kettle is 10MPa, CO 2 The flow rate is 10L / h, the ultrasonic auxiliary power is 200W, the entrainer is 95% ethanol solution, and the extraction time is 0.5h; the extract is directly passed into the rectification tower for rectification, the pressure in the rectification tower is 8Mpa, The temperatures in the four areas from top to bo...

Embodiment 2

[0019] (1) After fresh artichoke leaves are harvested, diseased leaves and yellow leaves are removed, rinsed to remove soil and other impurities, dried at low temperature, put into a crushing equipment and crushed, and passed through a 55-mesh sieve to obtain coarse artichoke leaf powder;

[0020] (2) soak the prepared artichoke leaf coarse powder with 85% ethanol solution, the ratio of solid to liquid is 1:5, and soak for 6 hours at room temperature;

[0021] (3) Put the soaked artichoke leaf meal into the ultrasonic extraction kettle for CO 2 Supercritical extraction; the temperature of the extraction kettle is 50°C, the pressure of the extraction kettle is 20MPa, CO 2 The flow rate is 30L / h, the ultrasonic auxiliary power is 600W, the entrainer is 95% ethanol solution, and the extraction time is 2h; the extract is directly passed into the rectification tower for rectification, the pressure in the rectification tower is 12Mpa, The temperatures in the four areas from top to ...

Embodiment 3

[0024] (1) After fresh artichoke leaves are harvested, diseased leaves and yellow leaves are removed, rinsed to remove soil and other impurities, dried at low temperature, put into a crushing equipment, crushed, and passed through a 60-mesh sieve to obtain coarse artichoke leaf powder;

[0025] (2) Soak the prepared artichoke leaf coarse powder with 95% ethanol solution, the ratio of solid to liquid is 1:10, and soak for 8 hours at room temperature;

[0026] (3) Put the soaked artichoke leaf meal into the ultrasonic extraction kettle for CO 2 Supercritical extraction; the temperature of the extraction kettle is 65°C, the pressure of the extraction kettle is 30MPa, CO 2 The flow rate is 50L / h, the ultrasonic auxiliary power is 800W, the entrainer is 95% ethanol solution, and the extraction time is 3h; the extract is directly passed into the rectification tower for rectification, the pressure in the rectification tower is 15Mpa, The temperatures in the four areas from top to bo...

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Abstract

The invention provides a method using ultrasonically-assisted supercritical extraction rectification to purify cynarin in globe artichoke. The method includes the steps of firstly, drying and crushing globe artichoke leaves, soaking with an ethanol aqueous solution, and loading into an ultrasonic extraction kettle; secondly, feeding supercritical CO2 into the ultrasonic extraction kettle, and soaking under certain pressure and temperature; thirdly, turning on an ultrasonic device, mixing the supercritical CO2 with 95% ethanol serving as the cosolvent for circulation extraction, and allowing the extracted supercritical solution to enter a rectifying tower for separation; fourthly, collecting a sample from the rectifying tower, and performing freeze drying to obtain reddish brown powder whose cynarin content can reach above 8.0%. The method has the advantages that the extraction process is assisted by ultrasonic, extraction efficiency can be increased, the supercritical CO2 extraction is combined with rectification, the products are separated according to the properties and boiling range during extraction, and the content of the cynarin in the extract can be increased greatly.

Description

technical field [0001] The invention relates to a method for extracting and purifying cynarin in artichokes, in particular to a method for ultrasonic-assisted supercritical extraction and rectification to purify cynarin in artichokes. Background technique [0002] Artichoke leaves are rich in phenolic acids such as cymarin (1,5-dicaffeoylquinic acid), chlorogenic acid, 1,3-dicaffeoylquinic acid, etc. It has the effects of protecting the liver, protecting the liver, and treating indigestion. Therefore, the development and utilization of artichoke leaves can increase the added value of artichoke products, and can provide a new raw material for the field of medicine and health care. Artichoke leaf extracts currently on the international market generally require a cynarin content higher than 2.5%. [0003] Current supercritical CO 2 The fluid extraction method has the following problems in the extraction and rectification of artichoke leaves: 1. The extraction capacity is low...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28C07C69/732C07C67/48A61K31/216
CPCA61K31/216A61K36/28A61K2236/37A61K2236/39C07C67/48C07C69/732Y02P20/141Y02P20/54
Inventor 邓爱华谢鹏王云谭小文罗娟
Owner HUNAN UNIV OF ARTS & SCI
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