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New application of benzatropine and pharmaceutically acceptable salt thereof

A technology of benzatropine and pharmacy, applied in the new application field of medicine

Inactive Publication Date: 2016-08-17
SUN YAT SEN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, due to the complexity of tumor growth and treatment, there is no information about benztropine and its pharmaceutically acceptable salts that can be used to prepare drugs against breast tumors and inhibit breast tumor metastasis.

Method used

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  • New application of benzatropine and pharmaceutically acceptable salt thereof
  • New application of benzatropine and pharmaceutically acceptable salt thereof
  • New application of benzatropine and pharmaceutically acceptable salt thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0029] (1) The effect of benztropine on the proliferation of breast cancer cells

[0030] 1 material

[0031] 1.1 Experimental cell lines 4T1-luc2cells, MDA-MB-231cells, SKBR3cells, MCF-7cells are all from ATCC company.

[0032] 1.2 Reagent CCK-8 kit, DMEM.

[0033] 1.3 Instrument 15mL centrifuge tubes, 1.5mL EP tubes, 1mL and 200μL pipette tips, and drains, prepared before the experiment, sterilized at 121°C for 30min, and then placed in an ultra-clean bench;

[0034] The 96-well culture plate is a disposable plastic product;

[0035] Ultra-clean bench, CO 2 Incubators, inverted microscopes, centrifuges, single-channel and eight-channel pipettes, cryotubes, cell counting plates, enzyme-linked immunoassay instruments, etc.

[0036] 1.4 Drugs Benztropine mesylate.

[0037] 1.5 Experimental method

[0038] cell culture

[0039] 1. Recovery

[0040] 1. Take out the cryopreservation tubes containing the four cell lines 4T1-luc2cells, MDA-MB-231cells, SKBR3cells, and MCF-7c...

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PUM

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Abstract

The invention relates to a new application of benzatropine and pharmaceutically acceptable salt thereof. The benzatropine and pharmaceutically acceptable salt thereof have a very strong inhibitory effect on the breast cancer cell lines MCF-7, 4T1-luc2, MDA-MB-231 and SKBR3; and the whole animal experiment also has an obvious effect and proves that the benzatropine and pharmaceutically acceptable salt thereof can be used for preparing medicines for resisting breast tumor and inhibiting breast tumor metastasis.

Description

technical field [0001] The invention relates to a new application of medicine, in particular to a new application of benztropine and a pharmaceutically acceptable salt thereof. Background technique [0002] In 1998, Wessler proposed the concept of non-neuronal cholinergic system, non-neuronal Ach, which is secreted from cells, acts on nAChR and mAChR on itself or adjacent cells through autocrine or paracrine mechanisms, and regulates cell activity. Basic functions, such as gene expression, amplification, differentiation, formation of cytoskeleton, cell-to-cell contact, etc., recent studies have found that non-neuronal cholinergic systems are closely related to the formation and development of various tumors. [0003] According to current literature, the nerves that innervate the mammary gland are mainly sensory nerves and sympathetic nerves, and the innervation of the mammary gland by the parasympathetic nerve or the vagus nerve is unclear. The sympathetic nerve affects the...

Claims

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Application Information

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IPC IPC(8): A61K31/46A61P35/00
CPCA61K31/46
Inventor 崔继红项辉王瑞霞
Owner SUN YAT SEN UNIV
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