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Metal-organic coordination polymer with organophosphorus hydrolase activity and preparation method and application thereof

A coordination polymer and metal-organic technology, applied in organic compound/hydride/coordination complex catalysts, chemical instruments and methods, chemical/physical processes, etc., can solve problems such as difficult use of liquid phase catalysts

Inactive Publication Date: 2016-08-03
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These studies are of great significance to the mechanism of catalytic degradation of organophosphorus, but these liquid phase catalysts are difficult to use in practice

Method used

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  • Metal-organic coordination polymer with organophosphorus hydrolase activity and preparation method and application thereof
  • Metal-organic coordination polymer with organophosphorus hydrolase activity and preparation method and application thereof
  • Metal-organic coordination polymer with organophosphorus hydrolase activity and preparation method and application thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Add 9.9 mg (0.03 mmol) of 3,3',5,5'-biphenyltetracarboxylic acid, 1 mL of deionized water, and 65 μL of 0.5 mol / L NaOH aqueous solution into the reaction flask, ultrasonicate at room temperature for 50 minutes, and then add 0.5 mL to A mixture of ionic water and 4mL N,N-dimethylformamide (DMF), stirred at room temperature until clear, then added 17.2mg (0.06mmol) ZnSO 4 ·7H 2 O, 12.1mg (0.03mmol) 1,3-bis[bis(2-imidazole)-hydroxymethyl]benzene, sealed, stirred at room temperature for about 11 hours and then left to stand for 2 hours, put it in an oven at a temperature of 0.33°C / min The heating rate was heated to 65 ° C, kept at a constant temperature for 3 days, cooled to room temperature, washed with DMF and then rinsed with acetone, and dried naturally to obtain light yellow crystals—a metal-organic coordination polymer with organophosphate hydrolase activity. The yield About 50% (calculated as Zn).

[0022] The structural unit of the obtained metal-organic coordinat...

Embodiment 2

[0027] The application of the polymer prepared by embodiment 1 in catalytic hydrolysis ethyl paraoxon, concrete experiment is as follows:

[0028] 1. Polymer catalyzed hydrolysis of ethyl paraoxon

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Abstract

The invention discloses a metal-organic coordination polymer with the organophosphorus hydrolase activity and a preparation method and application thereof. The structural unit of the polymer is [Zn(L1)0.5(L2)0.5].3DMF, wherein L1 represents 1,3-bis[di(2-diazole)-hydroxymethyl]phenyl, L2 represents 3,3',5,5'-biphenyl tetracarboxylic acid ions containing four carboxyls with no proton, DMF represents N,N-dimethyl formamide, and two DMF solvent molecules are out of order. The polymer belongs to a monoclinic system and a C2 / c space group. The polymer is synthesized under the low temperature through a solvothermal method, substrate organophosphorus can be effectively hydrolyzed, when pH is equal to 9.0, the ethyl paraoxon hydrolysis activity of the 0.1 mg / mL polymer is about 28 times the hydrolysis activity with no polymer, the Vmax of ethyl paraoxon hydrolysis reaction catalysis is 0.75 micro-mol / L.min, and the Km is 2.5 mmol / L. The polymer has the potential application value for constructing biometric sensors for degrading organophosphorus poison and detecting organophosphorus.

Description

technical field [0001] The invention belongs to the technical field of organophosphorus hydrolysis, and in particular relates to a metal organic coordination polymer with organophosphorus hydrolase activity and its preparation method and application. Background technique [0002] Organophosphorus compounds are highly toxic, can cause nervous system disorders, and seriously damage human health. In real life, incidents of organophosphorus pesticide residues continue to occur. Moreover, nerve agents similar in structure to organophosphates can also be used in wars and terrorist attacks, seriously threatening public health and national security. Natural organophosphate hydrolase can efficiently degrade organophosphate, but its stability is poor and its preparation is difficult. In recent years, some new achievements have been made in the research on the structure and function of organophosphate hydrolyzing enzymes, which provide a solid theoretical basis for the design and syn...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08G83/00B01J31/22A62D3/35A62D101/28
CPCA62D3/35A62D2101/28B01J31/1691B01J2531/26C08G83/008
Inventor 张耀东卓彩霞马雪娟夏梦凡张林
Owner SHAANXI NORMAL UNIV
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