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Recombinant human growth hormone and application thereof in promoting follicular development

A technology of human growth hormone and growth hormone, applied in the field of protein medicine, can solve the problem of undisclosed GH and other problems, and achieve the effect of reducing test-tube babies and improving pregnancy rate

Active Publication Date: 2016-07-27
CHANGCHUN GENESCIENCE PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, the prior art does not disclose that GH can be used to initiate the development of quiescent follicles, especially in the ovaries of patients with ovarian failure

Method used

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  • Recombinant human growth hormone and application thereof in promoting follicular development
  • Recombinant human growth hormone and application thereof in promoting follicular development

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1 PEG-GH improves the clinical trial of pregnancy rate

[0024] The long-acting growth hormone used in this example is PEGylated rhGH, which can be prepared by referring to the example of Chinese patent 200810050760, wherein the amino acid sequence of rhGH is shown in SEQ ID NO: 1 in the sequence list attached hereto.

[0025] 60 female infertility patients with informed consent were accepted for the trial. These patients had a basic FSH>40, AMH<0.5ng / ml, no antral follicles (2-9mm), and no gonadotropin-releasing hormone (GnRH) medication recently. history; tubal patency; no male infertility factors. These patients were randomly divided into two groups, among them, the patients in the test group (30 cases) were subcutaneously injected with long-acting growth hormone (calculated as rhGH, 2.25 mg) every 7 days, and at the same time, estradiol valerate 2 mg and dehydrogenated 2 mg were taken orally every day. Epiandrosterone 25 mg, and after endometrial thickne...

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Abstract

The invention discloses recombinant human growth hormone and the application thereof in promoting follicular development, belongs to the field of protein drugs, and relates to growth hormone (GH).The recombinant human growth hormone is suitable for promoting follicular development and can increase the rate of pregnancy.The invention further relates to a long-acting pharmaceutic preparation of GH and the application thereof.

Description

technical field [0001] The invention belongs to the field of protein medicine, in particular, the invention relates to growth hormone (GH), which is especially suitable for starting follicle development and improving pregnancy rate. In addition, the present invention also relates to long-acting pharmaceutical preparations of GH and the like. Background technique [0002] Growth hormone (Growth Hormone, GH) is a protein peptide hormone secreted by pituitary cells. At present, it is mostly used to treat children's dwarfism or Turner syndrome caused by pituitary insufficiency. It can also be used to promote children's growth, treat chronic renal insufficiency, AIDS failure, and aging. For example, see Chinese patent application No. 201480011475.9 and No. 200810051562.3, etc. [0003] However, growth hormone can promote the growth of body tissues other than nerves, promote body anabolism and protein synthesis, promote fat decomposition, and have an antagonistic effect on insul...

Claims

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Application Information

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IPC IPC(8): C07K14/61A61K38/27A61K47/48A61K31/565A61K31/5685A61K31/57A61P15/08
CPCA61K31/565A61K31/5685A61K31/57A61K38/00C07K14/61A61K2300/00
Inventor 金磊王思勤岳本亮刘云杉
Owner CHANGCHUN GENESCIENCE PHARM CO LTD
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