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Application of resveratrol and analogs of resveratrol in serving as HIV latent virus reservoir activating agents

A technology of resveratrol and latent virus, applied in antiviral agents, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of increasing immunity and weak anti-HIV effect, etc.

Inactive Publication Date: 2016-07-27
SHENZHEN CENT FOR DISEASE CONTROL & PREVENTION
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Problems solved by technology

[0013] Existing studies have shown that some derivatives (analogues) of resveratrol have certain anti-HIV effects (Huang Ning. Research on anti-HIV-1 activity and mechanism of resveratrol derivatives in vitro[D]. Dali College, 2008., Yang Zifeng, Hong Zhizhe, Tang Mingzeng, etc. Experimental study on the therapeutic effect of resveratrol on AIDS in mice [J]. Journal of Guangzhou University of Traditional Chinese Medicine, 2006,23(2):148-150. etc.), possible mechanism Including inhibiting HIV from entering cells, increasing the body's immunity, etc., but its anti-HIV effect is not strong, and resveratrol and its analogues have not been used to treat AIDS in clinical practice, nor have resveratrol and its analogues been used to treat AIDS. Report on AIDS cure

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  • Application of resveratrol and analogs of resveratrol in serving as HIV latent virus reservoir activating agents
  • Application of resveratrol and analogs of resveratrol in serving as HIV latent virus reservoir activating agents
  • Application of resveratrol and analogs of resveratrol in serving as HIV latent virus reservoir activating agents

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Embodiment Construction

[0019] The technical solution of the present invention will be further described below in combination with experimental data.

[0020] Experimental cell line

[0021] The J-latfulllengthclone10.6 cell model is an HIV latent cell model constructed by the AIDS Research Office of the National Institutes of Health (NIH), which integrates the HIV long terminal repeat sequence (LTR) and the green fluorescent protein GFP The gene is constructed together with the full-length HIV genome, fused in the chromosome of Jurkat T cells. As an internationally recognized cell model for the study of HIV latency and activation, when the drug has the activity of activating latent HIV, it will stimulate the expression of LTR-GFP, and flow cytometry can detect the increase in the fluorescence intensity of GFP, through the expression of GFP The amount of HIV activation can be observed to judge the activation effect of the drug. The J-latfulllengthclone10.6 cell model can not only express GFP, but t...

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Abstract

The invention discloses application of resveratrol and analogs of resveratrol in serving as HIV latent virus reservoir activating agents.The inventor proves that resveratrol can effectively stimulate rising of expression of GFP protein and a P24 antigen in a cell model through the HIV latent cell model J-lat full length clone 10.6.Thus, resveratrol and derivatives thereof can be independently used or jointly used with other activating medicine for activating the HIV latent virus reservoir in the body of an HIV patient and can serve as an alternative medicine molecule for curing aids.

Description

technical field [0001] The invention relates to a new application of a compound and a treatment method for AIDS, in particular to the application of resveratrol and its analogues as HIV latent virus library activators. Background technique [0002] Human immunodeficiency virus (humanimmunodeficiencyvirus, HIV) is a retroRNA virus that mainly attacks the immune system of the human body, causing various diseases and cancers to survive in the human body, and finally develops into AIDS (AIDS), that is, acquired immunodeficiency syndrome. [0003] In the first few years when AIDS was discovered, the average survival period of patients was only about 12 months due to the lack of effective drug treatment. In 1996, Professor He Dayi created the original "cocktail" therapy, Highly Active Antiretroviral Therapy (HAART), which treats AIDS through the combined use of three or more antiviral drugs. This therapy can delay the progress of the disease and prolong the life of AIDS patients,...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/167A61K31/05A61P31/18
CPCA61K31/167A61K31/05A61K2300/00
Inventor 王晓辉程锦泉杨峥嵘陈琳何太平
Owner SHENZHEN CENT FOR DISEASE CONTROL & PREVENTION
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