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Preparation method of ferrocenyl carbon nanotube composite material and application thereof

A carbon nanotube, composite material technology, applied in nanotechnology, analytical materials, nanotechnology and other directions, can solve the problem of low sensitivity and selectivity of electrochemical sensing, high sensitivity, stability and repeatability, narrow linear response range, etc. problem, to achieve the effect of sensitive electrochemical response, wide linear response range, easy separation and purification

Active Publication Date: 2016-07-20
ANHUI UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to overcome the complex synthesis process of sensing reagents in the existing electroanalytical chemical method for measuring dopamine, expensive raw materials, complicated post-treatment, difficult purification and separation, low sensitivity and selectivity of electrochemical sensing, and narrow linear response range And other shortcomings, through the simple reaction process, relatively mild reaction conditions, high yield and purity preparation and isolation of a new type of modifier probe molecule with strong electrocatalysis-ferrocene-based carbon nanotube composite material, to realize the electrochemical method Analysis and determination of dopamine. During the determination process, common interfering substances ascorbic acid and uric acid do not interfere with the determination of dopamine, and the electrochemical sensor used to construct the composite material to detect dopamine has a wide linear response range, low detection limit, high sensitivity, stability and repeatability. higher

Method used

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  • Preparation method of ferrocenyl carbon nanotube composite material and application thereof
  • Preparation method of ferrocenyl carbon nanotube composite material and application thereof
  • Preparation method of ferrocenyl carbon nanotube composite material and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Weigh 500 mg of carbon nanotubes and add them into a certain volume of 1:3 mixture of nitric acid and perchloric acid, place them in a powerful ultrasonic instrument for 7 hours, take them out and wash them with water twice until they are neutral, then Rinse with acetone and dry naturally in vacuo.

[0024] (2) Ultrasonic disperse 100 mg of purified oxidized multi-walled carbon nanotubes in 30 mL of anhydrous ethylenediamine for 30 min, then add 2.5 g of condensing agent N, N'-dicyclohexylcarbodiimide (DCC), and mix well , Heated to reflux in an oil bath at 120°C for 48h. After the reaction was completed, it was separated by centrifugation, the product was washed three times with absolute ethanol, and the product was vacuum-dried at 50° C. for 12 hours.

[0025] (3) Under anhydrous and oxygen-free conditions, weigh 600 mg of ferrocene monocarboxylic acid and dissolve it in 20 mL of anhydrous dichloromethane, stir to dissolve it fully, then quickly add 100 μL of pyr...

Embodiment 2

[0028] (1) Weigh 500 mg of carbon nanotubes and add them to a certain volume of 1:3 mixture of nitric acid and perchloric acid, place them in a powerful ultrasonic instrument for 5 hours, take them out and wash them with water twice until they are neutral, then Rinse with acetone and dry naturally in vacuo.

[0029] (2) Ultrasonic disperse 100 mg of purified oxidized multi-walled carbon nanotubes in 30 mL of anhydrous ethylenediamine for 30 min, then add 2.5 g of condensing agent N, N'-dicyclohexylcarbodiimide (DCC), and mix well , Heated to reflux in an oil bath at 120°C for 48h. After the reaction was completed, it was separated by centrifugation, the product was washed three times with absolute ethanol, and the product was vacuum-dried at 40° C. for 15 h.

[0030] (3) Under anhydrous and oxygen-free conditions, weigh 600 mg of ferrocenecarboxylic acid and dissolve it in 25 mL of anhydrous dichloromethane, stir to dissolve it fully, then quickly add 100 μL of pyridine and t...

Embodiment 3

[0033] (1) Weigh 500 mg of carbon nanotubes and add them to a certain volume of 1:3 mixture of nitric acid and perchloric acid, place them in a powerful ultrasonic instrument for 6 hours, take them out and wash them with water twice to neutral, then Rinse with acetone and dry naturally in vacuo.

[0034] (2) Ultrasonic disperse 100 mg of purified oxidized multi-walled carbon nanotubes in 30 mL of anhydrous ethylenediamine for 30 min, then add 2.5 g of condensing agent N, N'-dicyclohexylcarbodiimide (DCC), and mix well , Heated to reflux in an oil bath at 125°C for 48h. After the reaction was completed, it was separated by centrifugation, the product was washed three times with absolute ethanol, and the product was vacuum-dried at 50° C. for 12 hours.

[0035] (3) Under anhydrous and oxygen-free conditions, weigh 600 mg of ferrocene monocarboxylic acid and dissolve it in 30 mL of anhydrous dichloromethane, stir to fully dissolve, then quickly add 100 μL of pyridine and then sl...

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Abstract

The invention discloses a preparation method of a ferrocenyl carbon nanotube composite material and application thereof and belongs to the technical field of synthesis of inorganic materials. The preparation method of the composite material comprises the following steps: firstly carrying out oxidization and amination on carbon nanotubes and carrying out acylation on ferrocenecarboxylic acid, then taking triethylamine as an acid-binding agent in a dichloromethane solvent, and enabling the carbon nanotubes subjected to amination to react with activated ferrocenylformyl chloride to prepare the composite material. The preparation method of the composit material is simple and is mild in reaction condition; the product is convenient to separate and purify and stable in structure. The composite material takes the carbon nanotubes with large specific surface area and high conductivity as support materials; ferrocenyl derivatives which can be used as electron media and provided with excellent electrochemical reversibility are covalently coupled on the surfaces of the carbon nanotubes, so that the composite material is excellent in effect of redox reaction for electrochemically catalyzing dopamine; the common interference matters including ascorbic acid and uric acid have no interference on detection of dopamine; the composite material is wide in linear response range and high in sensitivity and repeatability for detection of dopamine.

Description

technical field [0001] The invention belongs to the technical field of inorganic material synthesis, and in particular relates to a method for conveniently preparing a ferrocene-based carbon nanotube composite material and the application of the composite material in the electrochemical reaction of dopamine. Background technique [0002] As a catecholamine neurotransmitter, dopamine is mainly distributed in the human central nervous system, mammalian serum and cell fluid, and plays an important role in regulating kidney function and hormone secretion. If dopamine is lacking in the body, it will lead to neurological disorders such as Parkinson's disease, attention deficit hyperactivity disorder and restless legs syndrome, and even schizophrenia. Therefore, real-time and accurate analysis of dopamine is of great significance in disease diagnosis, treatment, neurophysiological function and further research on the physiological role of dopamine. The detection methods of dopamin...

Claims

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Application Information

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IPC IPC(8): C01B31/02B82Y40/00B82Y30/00G01N27/30
CPCG01N27/308
Inventor 吴芳辉张奥亚程源晟魏先文
Owner ANHUI UNIVERSITY OF TECHNOLOGY
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