Nanometer 1H-19F-31P multi-nuclear magnetic resonance molecular imaging probe transmitted through respiratory tract and preparing method thereof

Abstract

The invention discloses a nanometer 1H-19F-31P multi-nuclear magnetic resonance molecular imaging probe transmitted through the respiratory tract and a preparing method thereof and belongs to the technical field of medical diagnosis.The preparing method comprises the steps of 1, evenly mixing one or more phospholipids surface active agents, dissolving the mixture with chloroform or a chloroform and methyl alcohol mixed solvent, and conducting drying and dispersion in water in sequence to obtain a phospholipids surface active agent blend; 2, evenly dispersing perfluoro-carbon and glycerinum in the surface active agent blend; 3, removing components not effectively coated, and conducting purification to obtain the probe.Researches show that after the probe is transmitted through the respiratory tract, tumor lesion position multi-nuclear imaging information can be provided, the dosage of an imaging contrast agent is reduced, and lung cancer molecular imaging in vitro detection effect is improved.

Description

technical field [0001] The invention relates to a nano-molecular imaging probe and a preparation method thereof, in particular to a multi-nuclear magnetic resonance molecular imaging probe for lung cancer diagnosis and typing and a preparation method thereof. It belongs to the technical field of medical diagnosis. Background technique [0002] The lungs, located in the chest cavity, are the internal organs used for breathing and the place for gas exchange. Lung cancer is the most common primary malignant tumor of the lung. The vast majority of lung cancers originate from the bronchial mucosal epithelium, so it is also called bronchial lung cancer. Lung cancer is located deep in the air-containing lung tissue. The molecular classification of tumors based on polymorphisms of molecular targets (genes, proteins) and differences in cellular epigenetics is directly related to the selection of tumor molecular targeted therapy, which can reduce blindness and increase pertinence. ...

AI Technical Summary

Problems solved by technology

However, the disadvantage of MRI lies in its low detection sensitivity. Therefore, the development of new MRI molecular imaging probes delivered through the respiratory route can directly act on lung cancer lesions, which can improve the detection sensitivity of MRI and give full play to the high-resolution anatomical characteristics of MRI. Will become a powerful and powerful tool in the field of lung cancer molecular imaging research

[0005] In summary, perfluorocarbons are an excellent 19 F-MRI imaging contrast agent, its physical and chemical properties show its great potential to be delivered through the respiratory tract, but the use of perfluorocarbons as nanomolecular imaging probes delivered through the respiratory tract for the detection and molecular typing of lung cancer lesions Internationally unprecedented

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