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Compound herba houttuyniae syrup, pharmaceutical application thereof in treatment of encephalomyelitis and detection method

A technology of compound Houttuynia cordata and quality testing method, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, measuring devices, etc., and can solve virus drug resistance, affect curative effect, large side effects, etc. question

Active Publication Date: 2016-07-20
HEILONGJIANG ZHONGGUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since these drugs are all analogs of viral enzyme substrates, the virus will develop drug resistance during application, which will affect the curative effect and have relatively large side effects. Therefore, it is still meaningful to find new, high-efficiency and low-toxicity anti-HSV-1 drugs Act of

Method used

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  • Compound herba houttuyniae syrup, pharmaceutical application thereof in treatment of encephalomyelitis and detection method
  • Compound herba houttuyniae syrup, pharmaceutical application thereof in treatment of encephalomyelitis and detection method
  • Compound herba houttuyniae syrup, pharmaceutical application thereof in treatment of encephalomyelitis and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0151] Prescription: Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix isatidis 25g, Forsythia 10g, Honeysuckle 10g.

[0152] Preparation method: Take Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix Radix 25g, Forsythia 10g, Honeysuckle 10g, add 1190mL water to decoct twice, each time for 2 hours, combine the decoction, filter, the relative density of the filtrate concentration is 1.18-1.20 Add ethanol to the clear ointment until the alcohol content reaches 70%, stir well, let it stand for 24 hours, take the supernatant, filter, and recover the ethanol from the filtrate under reduced pressure and concentrate to obtain concentrated medicinal liquid; take sucrose separately to make a single Syrup, add the above-mentioned concentrated medicinal solution, add 1000mL of water, stir well, filter, fill, and obtain.

[0153] Content determination:

[0154] Determination of d-pineol and levo-elitorin by high-performance liquid chromatography:

[0155] (1) Chroma...

Embodiment 2

[0170] Prescription: Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix isatidis 25g, Forsythia 10g, Honeysuckle 10g.

[0171] Preparation method: Take Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix Radix 25g, Forsythia 10g, Honeysuckle 10g, add 1190mL water to decoct twice, each time for 2 hours, combine the decoction, filter, the relative density of the filtrate concentration is 1.18-1.20 Add ethanol to the clear ointment until the alcohol content reaches 70%, stir well, let it stand for 24 hours, take the supernatant, filter, and recover the ethanol from the filtrate under reduced pressure and concentrate to obtain concentrated medicinal liquid; take sucrose separately to make a single Syrup, add the above-mentioned concentrated medicinal solution, add 1000mL of water, stir well, filter, fill, and obtain.

[0172] Content determination:

[0173] Determination of d-pineol and levo-elitorin by high-performance liquid chromatography:

[0174] (1) Chroma...

Embodiment 3

[0189] Prescription: Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix isatidis 25g, Forsythia 10g, Honeysuckle 10g.

[0190] Preparation method: Take Houttuynia cordata 100g, Scutellaria baicalensis 25g, Radix Radix 25g, Forsythia 10g, Honeysuckle 10g, add 1190mL water to decoct twice, each time for 2 hours, combine the decoction, filter, the relative density of the filtrate concentration is 1.18-1.20 Add ethanol to the clear ointment until the alcohol content reaches 70%, stir well, let it stand for 24 hours, take the supernatant, filter, and recover the ethanol from the filtrate under reduced pressure and concentrate to obtain concentrated medicinal liquid; take sucrose separately to make a single Syrup, add the above-mentioned concentrated medicinal solution, add 1000mL of water, stir well, filter, fill, and obtain.

[0191] Content determination:

[0192] Determination of d-pineol and levo-elitorin by high-performance liquid chromatography:

[0193] (1) Chroma...

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Abstract

The invention relates to the field of traditional Chinese medicine, in particular to compound herba houttuyniae syrup, pharmaceutical application thereof in treatment of encephalomyelitis and a detection method. The compound herba houttuyniae syrup is prepared from the following raw materials in parts by weight: 100 parts of herba houttuyniae, 25 parts of radix scutellariae, 25 parts of radix isatidis, 10 parts of fructus forsythiae and 10 parts of lonicera japonica. A preparation method of the syrup comprises the following steps: preparing herba houttuyniae, radix scutellariae, radix isatidis, fructus forsythiae and lonicera japonica, adding water in an amount which is 7 times that of the raw materials for decocting twice for 2 hours, combining decoction solutions, filtering, concentrating filtrate into clear paste, adding ethanol till the alcohol content is up to 70 percent, stirring uniformly, standing, filtering, recovering ethanol from the filtrate under reduced pressure, and concentrating to obtain concentrated liquid medicine; preparing sucrose into simple syrup, adding the concentrated liquid medicine, adding water, stirring uniformly, filtering, and filling to obtain the compound herba houttuyniae syrup. The compound herba houttuyniae syrup can be used for treating encephalomyelitis and herpes simplex virus encephalitis. The invention further provides a method for measuring content of the compound herba houttuyniae syrup through high performance liquid chromatography and a gas chromatographic method.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicines, in particular to compound Houttuynia cordata syrup and its pharmaceutical use and detection method for treating encephalomyelitis. Background technique [0002] Herpes simplex encephalitis (HSVE), abbreviated as herpes simplex encephalitis (HSE), is the most common non-epidemic viral encephalitis clinically, with high mortality and disability rates. More than 90% of herpes simplex virus encephalitis caused by herpes simplex virus type 1 (herpes simplex virus type 1, HSV-1). [0003] HSVE often involves the temporal lobe, frontal lobe, and limbic system of the brain, causing hemorrhage and necrosis of brain tissue, so it is also called acute necrotizing encephalitis or hemorrhagic encephalitis. Since HSVE has the characteristics of high mortality, serious condition, and rapid development, and the therapeutic effect is affected by the patient's level of consciousness and neurological d...

Claims

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Application Information

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IPC IPC(8): A61K36/78A61P31/22A61P25/00G01N30/02
CPCA61K9/0095A61K36/195A61K36/315A61K36/355A61K36/539A61K36/634A61K36/78A61K47/26A61K2236/331A61K2236/39A61K2236/51A61K2236/53G01N30/02G01N2030/025G01N2030/027A61K2300/00
Inventor 张树乘赵伟耿宝星郑秀娟程淑云孙莉郭婷婷
Owner HEILONGJIANG ZHONGGUI PHARMA
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