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Traditional Chinese medicine composition with effects of resisting periodontitis and protecting periodontium and preparation method and application thereof

A periodontal tissue and composition technology, applied in the field of traditional Chinese medicine compositions, can solve the problems of superinfection, drug resistance and the like, and achieve the effects of good safety, lowering blood sugar, and protecting periodontal tissue

Inactive Publication Date: 2016-07-06
NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the most serious consequence of long-term use of broad-spectrum antibiotics is drug resistance and even superinfection

Method used

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  • Traditional Chinese medicine composition with effects of resisting periodontitis and protecting periodontium and preparation method and application thereof
  • Traditional Chinese medicine composition with effects of resisting periodontitis and protecting periodontium and preparation method and application thereof
  • Traditional Chinese medicine composition with effects of resisting periodontitis and protecting periodontium and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Example 1 Orthogonal process to investigate the preparation optimization and anti-inflammatory effect of traditional Chinese medicine composition

[0027] 1. Medicines and materials

[0028] 1. Medicinal materials: Honeysuckle 180g, Viola nigra 180g, Scutellaria 180g, Dandelion 180g, Wild chrysanthemum 180g, Pueraria lobata 120g, Salvia 120g, Angelica dahurica 180g, Agastache 120g, purchased from Suzhou Tianling Decoction Pieces Co., Ltd.

[0029] 2. Animals: clean grade KM mice (Shanghai Slack Laboratory Animal Co., Ltd.), animal license number: SCXK (Shanghai) 2007-0005, half male and half male, weight 20-25g;

[0030] 3. Drugs: carrageenan (Sigma company, batch number: 09JK1394); aspirin effervescent tablets (Bayer company, Germany, specification and batch number: 0.5 g / tablet, H32026201).

[0031] 2. Experimental method

[0032] 1. Orthogonal experimental design

[0033] Weigh 180 g of honeysuckle, 180 g of Viola serrata, 180 g of scutellaria baicalensis, 180 g of dandelion, 18...

Embodiment 2

[0047] The preparation method of the traditional Chinese medicine composition with anti-periodontitis and protection of periodontal tissues further comprises the following steps:

[0048] (1) Mix 180g of honeysuckle, 180g of violet, scutellaria 180g, dandelion 180g, wild chrysanthemum 180g, kudzu root 120g, danshen 120g, angelica 180g, and Huoxiang 120g, add water 10 times the weight of the medicinal material, and cook 3 times, decocting for 3 hours each time, combine the decocting liquid, filter, and collect the filtrate;

[0049] (2) Take the filtrate obtained in step (1), add ethanol to make the ethanol volume concentration 65%, precipitate, filter, remove impurities, and concentrate under reduced pressure to prepare an extract of the traditional Chinese medicine composition.

Embodiment 3

[0050] Example 3 Effect of Chinese medicine composition on foot swelling and cytokines in mice with carrageenan inflammation

[0051] 1. Medicines and materials

[0052] 1. Animals: clean grade KM mice (Shanghai Slack Laboratory Animal Co., Ltd.), animal license number: SCXK (Shanghai) 2007-0005, half male and half male, weight 20-25g;

[0053] 2. Drugs: carrageenan (Sigma, batch number: 09JK1394); aspirin effervescent tablets (Bayer, Germany, specification and batch number: 0.5 g / tablet, H32026201). The extract of the traditional Chinese medicine composition prepared in Example 2.

[0054] 2. Experimental method

[0055] 1. Mouse carrageenan inflammation model construction and foot circumference measurement

[0056] Take KM mice (body weight 20g~25g) and divide them into 15 groups, each with 3 mice: model control group (administered saline, 0.2ml / 10g), positive control group (administered aspirin, 5mg / 10g, dissolved in 0.2 ml normal saline), traditional Chinese medicine composition ex...

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Abstract

The invention discloses a traditional Chinese medicine composition with effects of resisting periodontitis and protecting periodontium and a preparation method and application thereof. The traditional Chinese medicine composition is prepared from, by weight, 2-5 parts of honeysuckle flowers, 1-5 parts of herba violae, 1-5 parts of radix scutellariae, 2-5 parts of herba taraxaci, 1-5 parts of flos chrysanthemi indici, 1-5 parts of kudzuvine roots, 1-5 parts of radix salvia miltiorrhiza, 1-5 parts of radix angelicae and 1-5 parts of wrinkled gianthyssop herb. The traditional Chinese medicine composition with the effect of treating diabetic periodontitis is scientific and reasonable in proportion; animal model experiment results show that the traditional Chinese medicine composition has the effects of significantly relieving the inflammatory reaction action, lowering the blood glucose and effectively protecting the periodontium, can be used for preparing drugs or healthcare products or daily necessities for preventing and treating the periodontitis and is suitable for patients suffering from the periodontitis, especially the patients suffering from the periodontitis and diabetes; in addition, no obvious toxic or side effect is found in the experiment process, and the traditional Chinese medicine composition is good in safety, can be conveniently prepared into multiple clinical dosage forms and is convenient to take.

Description

Technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition with anti-periodontitis, protection of periodontal tissues, and blood sugar lowering effects and a preparation method thereof. Background technique [0002] Periodontitis, a chronic inflammation that affects the gums and periodontal tissues, is a destructive disease and the main cause of tooth loss in adults. According to the survey, the prevalence of adult periodontitis in my country is as high as 80% to 90%. A major discovery of medical research in recent years is that periodontitis not only affects periodontal tissues, but also seriously endangers people’s overall health. The relationship between periodontitis and overall health has become a hot spot for medical experts and stomatologists at home and abroad, especially teeth. The relationship between Zhouyan and diabetes. At present, with the change of lifestyle and the accel...

Claims

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Application Information

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IPC IPC(8): A61K36/86A61P1/02A61P3/10A61K8/97A61Q11/00
CPCA61K36/355A61K8/97A61K36/232A61K36/287A61K36/288A61K36/488A61K36/532A61K36/537A61K36/539A61K36/86A61K2236/331A61K2236/53A61Q11/00A61K2300/00
Inventor 朱悦顾瑶华
Owner NANJING UNIVERSITY OF TRADITIONAL CHINESE MEDICINE
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