Modulation of inflammatory response following endovascular treatment

Abstract

A method of treating an aortic aneurysm of a patient with an endovascular graft system and mitigating post implant syndrome associated therewith comprises placing at least one prosthesis across an aneurysmal space. The prosthesis comprises a double-walled filling structure and a stent-graft. The stent graft is radially expanded at a first pressure and the filing structure is filled with a first filing agent to contact a thrombus in the aortic aneurysmal space. After the first filling agent is removed, the filling structure is filled with a second filling agent to contact the thrombus. Next the stent-graft is expanded at a second pressure causing the filing structure to place an effective amount of pressure on the thrombus and substantially mitigating the effects of post implant syndrome associated with the prosthesis.

Description

CROSS-REFERENCE TO RELATED PATENT APPLICATIONS[0001]This application claims priority from U.S. Provisional Patent App. Ser. No. 62 / 661,569 filed Apr. 23, 2018, the entire contents of which are incorporated by reference herein.TECHNICAL FIELD[0002]The present technology relates generally to endoluminal vascular prostheses and methods of placing such prostheses. More particularly, various embodiments relate to endoluminal vascular prostheses and methods of placing such prostheses for treating aortic aneurysms.BACKGROUND[0003]The following description of the background is provided simply as an aid for understanding without any admission that it describes or constitutes prior art.[0004]Aneurysms are enlargements or bulges in blood vessels that are often prone to rupture and which therefore present a serious risk to a patient. Aneurysms may occur in any blood vessel but are of particular concern when they occur in the cerebral vasculature or the patient's aorta.[0005]Abdominal aortic ane...

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Benefits of technology

[0009]The present disclosure provides improved methods, systems and devices for treatment of aneurysms, including aortic aneurysms. Various embodiments allow for reducing acute and/or chronic post-implantation inflammatory responses, among other things, upon deployment of endovascular graft systems. Chronic inflammatory responses can potentially lead to major adverse events such as major adverse cardiac events (MACE), acute renal failure, readmission, and even death. Various embodiments provide improved compositions, systems, and methods of placing such systems that will modulate and minimize acute as well as chronic inflammation post-implantation. Accordingly, in the exemplary embodiments, a method is provided for treating an aortic aneurysm of a patient using an endovascular graft system which mitigates post implant syndrome associated with the treatment. The method includes placing at least one prosthesis in the aortic aneurysmal space, the prosthesis including a stent-graft and a double-walled filling structure. The filling structure includes an outer wall, an inner wall, and a fillable space between the outer wall and the inner wall. As described in further detail below, the system may include a plurality of filling structures and stent-grafts. Moreover, the order placement and deployment (including expansion and filling) may vary. Following placement of the stent-graft across the aneurysm, it is radially expanded at a first pressure with an expanding structure such as an expansion balloon. The filling structure is then filled with a first filling agent such that the filling structure expands and contacts a thrombus disposed in the aneurysmal space. Once the first filling agent is removed, the filling structure is then filled with a second filling agent such that the filling structure expands and contacts the thrombus again. Next, the stent-graft is radially inflated with an expansion balloon at a second pressure, with the second pressure being greater than the first pressure, which causes the filling structure with the second filling agent to place an effective amount of pressure on the thrombus. Generally, the effective amount of pressure placed on

Problems solved by technology

Chronic inflammatory responses can potentially lead to major adverse events such as m

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