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Application of glycan superpara magnetism ferric oxide to preparation of medicine for treating cardiovascular disease

A superparamagnetic iron oxide and cardiovascular technology, applied in the field of medicine, can solve problems such as myocardial cell damage, heart rupture, and myocardial cell death, and achieve the effects of increasing coronary flow, reducing myocardial infarction rate, and increasing content

Inactive Publication Date: 2016-07-06
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, this method itself has some insurmountable side effects, such as the perfusion process itself will cause further damage to cardiomyocytes, and even lead to the death of cardiomyocytes, arrhythmia and heart rupture

Method used

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  • Application of glycan superpara magnetism ferric oxide to preparation of medicine for treating cardiovascular disease
  • Application of glycan superpara magnetism ferric oxide to preparation of medicine for treating cardiovascular disease
  • Application of glycan superpara magnetism ferric oxide to preparation of medicine for treating cardiovascular disease

Examples

Experimental program
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Effect test

Embodiment 1

[0017] Example 1 Effect of Polysaccharide Superparamagnetic Iron Oxide on Cardiac Function After Ischemia-Reperfusion in Guinea Pig Isolated Heart

[0018] First, construct the isolated guinea pig heart ischemia-reperfusion experimental model: guinea pigs (clean guinea pigs, body weight 300-400 g, provided by Qinglong Mountain Animal Breeding Farm, Jiangning, Nanjing) quickly took out the heart after being stunned, and placed it in a room at 0-4°C. In oxygen-saturated Rockwell solution (NaCl154.0mM, KCl5.6mM, CaCl22.1mM, NaHCO35.9mM, Glucose5.5mM), aortic catheterization was performed, and after fixation, the langen-dorff device (purchased from Chengdu Taimeng Biotechnology Co., Ltd. company). Perfuse with oxygenated Rockwell's solution, the perfusion temperature is 37.0±0.5°C, and the height is 60-80cm. After 15 minutes of stability, the perfusion is stopped for 30 minutes, and the perfusion is resumed for 30 minutes. At the same time, reperfusion was continued with a consta...

Embodiment 2

[0024] Example 2 Effect of polysaccharide superparamagnetic iron oxide on myocardial ischemia caused by coronary artery ligation in rats

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Abstract

The invention relates to application of glycan superpara magnetism ferric oxide to preparation of a medicine for treating cardiovascular diseases. Test data show that glycan superpara magnetism ferric oxide can improve heart ischemia, increase coronary flow and reduce the probability of myocardial infarction of patients suffering from myocardial ischemia. By adopting the glycan superpara magnetism ferric oxide, the contents of malondialdehyde (MDA) and serum creatine kinase (CK) in serum can be reduced, the content of superoxide dismutase (SOD) can be increased, and states of cardiovascular diseases can be improved. As superpara magnetism iron sesquioxide (gamma-Fe2O3) nanoparticles are taken as a kernel and polydextrose sorbitol carboxymethyl ether is taken as a modification shell of the glycan superpara magnetism ferric oxide, symptoms such as myocardial ischemia of the vascular diseases can be effectively treated, and the lycan superpara magnetism ferric oxide is good in function on cardiac muscle, remarkable in treatment effect and good in security.

Description

technical field [0001] The invention belongs to the technical field of medicines, and relates to the application of polysaccharide superparamagnetic iron oxide in the preparation of medicines for treating cardiovascular diseases. technical background [0002] Cardiovascular disease is the most harmful disease to human life and health in the world, and the number of deaths due to cardiovascular disease is increasing at a rapid rate every year. There are many types of cardiovascular diseases, and their causes are also varied, and most of them have not been effectively verified so far. Myocardial ischemia, the most common symptom of cardiovascular disease, is damage to the heart muscle due to a lack of adequate blood flow to the heart. Insufficient blood flow can lead to myocardial hypoxia, leading to coronary heart disease, angina pectoris, and even myocardial infarction. In addition, cardiovascular disease will also have a bad impact on other systems and organs in the human...

Claims

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Application Information

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IPC IPC(8): A61K33/26A61K9/51A61K47/36A61P9/10A61P9/00
CPCA61K33/26A61K9/5161
Inventor 顾宁熊非张松
Owner SOUTHEAST UNIV
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