Inhibitor for HIF-1alpha relevant to non-small cell lung cancer radiotherapy

Abstract

The invention discloses an inhibitor for HIF-1alpha relevant to non-small cell lung cancer radiotherapy, and discloses application of a miRNA-21 inhibitor in preparation of drugs for reducing the HIF-1alpha level in non-small cell lung cancer cells. The nucleotide sequence of the miRNA-21 is 5'-UAGCUUAUCAGACUGAUGUUGA-3' and is shown as SEQ ID NO.1. When the miRNA inhibitor is used, the content of HIF-1alpha which has radiotherapy resistance in the non-small cell lung cancer cells can be reduced, therefore, radiosensitivity of the non-small cell lung cancer cells can be improved, and the miRNA-21 inhibitor is more beneficial for the curative effect of radiotherapy of a non-small cell lung cancer.

Description

technical field [0001] The invention relates to the field of medical medicine, in particular to the application of a miRNA-21 inhibitor in the preparation of a medicine for reducing the level of HIF-1α in non-small cell lung cancer. Background technique [0002] miRNAs are functional non-coding RNAs, 20-24 nucleotides in length, that play an important role in controlling the stability and transcription efficiency of target miRNAs. The mature miRNA induces non-expression of the transcribed gene by including the complementary sequence of the target gene and including the 3' non-transcribed region. Therefore, the abnormal expression of miRNA may affect the transcription of target genes, and further affect the signaling pathways related to cancer, involving cell cycle regulation, apoptosis, mutation, migration and metabolism. Tumor tissues often show reduced amounts of functional miRNAs; however, miRNA-21 has been documented to play a role in carcinogenesis (oncomiR), and its h...

AI Technical Summary

Problems solved by technology

Studies have shown that the increase in the expression level of HIF-1α can lead to a decrease in the efficacy of radiotherapy, but some literatures believe that HIF-1α does not affect the radiosensitivity of tumor cells

[0006] Although there are many reports on the radiosensitization of lung cancer cells, how miRNA-21 is controlled in radiotherapy-resistant non-small cell lung cancer cells is still unclear.

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